High Uniformity Distribution of Fe@Au Preparation by a Micro-Emulsion Method

Abstract

In this study, the characterisation and composition of Fe@Au NPs were discussed. Au-coated Fe core-shell is a type of nanoparticle that contains a magnetic Fe NPs core with a fine layer of Au NPs synthesised by the micro-emulsion method. These Fe@Au NPs are characterised by Atomic Force Microscope (AFM), Scanning Electron Microscopy (SEM), High-Resolution Transmission Electron Microscopy (TEM) and UV-Visible Spectrophotometer. The best result and the smallest nanosize was obtained at a temperature of 38°C and HAuCl4.3H2O Volume 200mg. The size of Fe@Au NPs was 63.65 nm, the Fe NP’s core diameter was 32.47nm and the Au NP’s shell thickness was approximately 31.18 nm. Optimum results mention that temperature and the HAuCl4.3H2O volume play a great role in the formation of small, monodisperse Fe@Au NPs for future use as a drug delivery means to treat different types of cancer.

Smart Nanoformulation Based on Polymeric Magnetic Nanoparticles and Vincristine Drug: A Novel Therapy for Apoptotic Gene Expression in Tumors

“…This finding clearly demonstrates that FA-DEX-VNC-SPION is a really powerful carrier that can be used for Tera-1 cancer cell-targeted drugs as a delivery mechanism. The results were considered satisfactory for targeted applications and are in agreement with those previously published [ 9 , 11 , 13 , 15 ].…”

“…However, the main challenge for VNC is its cytotoxicity and nonspecific bio-distribution, which cause severe side effects [ 7 ]. Through inserting the active ingredient into suitable nanomaterials with ideal size, surface and charge characteristics [ 8 , 9 ], the drug covalently attached SPION has been studied in order to provide tumor-site anticancer agents [ 10 ]. Researchers have drawn considerable attention to specific features of SPIONs, like nontoxicity and fast external magnetic field reactions, especially in the identification and treatment of potential cancers.…”

Design and Synthesis of Multi-Functional Superparamagnetic Core-Gold Shell Nanoparticles Coated with Chitosan and Folate for Targeted Antitumor Therapy

“…Chemical co-precipitation was adopted to generate SPIONs because it allows for feasible large-scale and relatively low-cost production [ 29 ]. Au shell protects SPION against oxidation and makes it sensitive to light absorption [ 30 ]. CS was used as a stabilizing factor in the presence of FA for nanoparticle surface modification to prevent SPION agglomeration [ 31 ].…”

Study the Effect of Laser Wavelength on Polymeric Metallic Nanocarrier Synthesis for Curcumin Delivery in Prostate Cancer Therapy: In Vitro Study

“…The gold addition in Fe@Au can promote the stability and Journal of Applied Sciences and Nanotechnology dispersibility of core particles (Fe) and their characteristic enhance [12,13]. The fabrication of (Au) shell (Fe) core nanoparticles has attracted attention because of potential applications like targeted delivery, medical imaging, bioseparation, electrochemical sensors, and cancer treatment [14]. Gold protects the iron core from oxidation [15].…”