High urate concentration is associated with elevated blood pressure in schoolchildren

Reis, Luiza Naujorks; Reuter, Cézane Priscila; Renner, Jane Dagmar Pollo; Burgos, Leandro Tibiriçá; Franke, Silvia Isabel Rech; Burgos, Míria Suzana

doi:10.1515/jpem-2018-0227

Cited by 11 publications

(13 citation statements)

References 18 publications

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“…We identified urate and nonanoate as key metabolites that mark this relationship. Our finding with respect to urate corroborates a longstanding literature on the relationship between sugar (in particular, fructose) intake and gout [9], a condition caused by high serum uric acid in tissues (hyperuricemia), as well as the established link between hyperuricemia and high blood pressure in adults [10] and children [11,12]. The process of phosphorylation of fructose, the first step of fructose metabolism, leads to an increase in circulating uric acid as a byproduct [13].…”

Section: Discussionsupporting

confidence: 90%

Urate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort

et al. 2019

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We sought to identify metabolites that mark the relationship of sugar-sweetened beverage (SSB) intake with adiposity and metabolic risk among boys (n = 114) and girls (n = 128) aged 8–14 years. We conducted the analysis in three steps: (1) linear regression to examine associations of SSB intake (quartiles) with adiposity, glycemia, lipids, and blood pressure (BP); (2) least absolute shrinkage and selection operator (LASSO) regression to identify SSB-associated metabolites from an untargeted dataset of 938 metabolites; and (3) linear regression to determine whether SSB-related metabolites are also associated with adiposity and metabolic risk. In girls, SSB intake was associated with marginally higher BP (Q2 vs, Q1: 1.11 [−3.90, 6.13], Q3 vs. Q1: 1.16 [−3.81, 6.13], Q4 vs. Q1: 4.65 [−0.22, 9.53] mmHg systolic blood pressure (SBP); P-trend = 0.07). In boys, SSB intake corresponded with higher C-peptide insulin resistance (Q2 vs. Q1: 0.06 [−0.06, 0.19], Q3 vs. Q1: 0.01 [−0.12, 0.14], Q4 vs. Q1: 0.17 [0.04, 0.30] ng/mL; P-trend = 0.03) and leptin (P-trend = 0.02). LASSO identified 6 annotated metabolites in girls (5-methyl-tetrohydrofolate, phenylephrine, urate, nonanoate, deoxyuridine, sn-glycero-3-phosphocholine) and 3 annotated metabolites in boys (2-piperidinone, octanoylcarnitine, catechol) associated with SSB intake. Among girls, urate and nonanoate marked the relationship of SSB intake with BP. None of the SSB-associated metabolites were related to health outcomes in boys.

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Section: Discussionsupporting

confidence: 90%

Urate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort

et al. 2019

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“…In this study, the mean SUA levels of Korean children and adolescents differed by 5.9±0.1 mg/dL and 4.6±0.1 mg/dL for males and females, respectively. These differences were also reported in prior studies in other countries, and studies in Brazil and Japan for children and adolescents also found that males have higher SUA levels than females [7,8]. In this study, male SUA levels increased significantly with age, whereas female SUA levels according to age was not statistically significant but showed an increasing tendency.…”

Section: Discussionsupporting

confidence: 85%

“…In children and adolescents with hyperuricemia, the proportion of high SBP, which is a component of MetS and a CMRF, was higher. Hyperuricemia is also associated with hypertension in studies on children and adolescents in Brazil and the United States [7,10]. The Bogalusa Heart Study reported that the SUA level in childhood is a risk of developing adult hypertension after a 12-year follow-up period [34].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey

Lee

2019

Korean J Pediatr

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Investigating the prevalence of hyperuricemia and its association with metabolic syndrome (MetS) and cardiometabolic risk factors (CMRFs) in Korean children and adolescents. Methods: This cross-sectional survey used data from the 7th Korea National Health and Nutrition Examination Survey (2016-2017); 1,256 males and females aged 10-18 years were included. Hyperuricemia was defined as serum uric acid levels were >6.6 mg/dL at 10-11 years of age (both sexes), >7.7 mg/dL for males at 12-18 years of age and >5.7 mg/dL for females at 12-18 years of age. MetS was defined by the International Diabetes Federation criteria. Logistic regression analysis was used to analyze hyperuricemia-associated risk factors. Results: The prevalence of hyperuricemia was 9.4% (male, 8.4%; female, 10.5%) (P<0.281). After adjusting for sociodemographic factors and health behaviors in multivariate analysis (model 1), the odds ratio (OR) for hyperuricemia of MetS was 3.05 (95% confidence interval [CI], 1.17-7.92; P=0.022). After adjusting for the same variables in model 1 plus obesity and all MetS components (model 2), only abdominal obesity was significant, and the OR for hyperuricemia was 3.38 (95% CI, 1.72-6.63; P< 0.001) After adjusting for the same variables in model 1 plus body mass index (BMI) z scores and all MetS components except abdominal obesity (model 3), only BMI z scores was significant, and the OR for hyperuricemia was 1.59 (95% CI, 1.34-1.89; P<0.001). Conclusion: MetS, abdominal obesity, and BMI z scores were CMRFs significantly associated with hyperuricemia in Korean children and adolescents. Therefore, attention should be paid to hyperuricemia in patients with obesity or MetS.

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“…In unadjusted analyses, serum uric acid concentration was significantly related to each outcome criterion; however, in fully adjusted multivariate models, this significance could no longer be shown. Nevertheless, as serum uric acid levels show significant associations with eGFR and in some studies with blood pressure, 34,41,42,49 the topic of hyperuricemia should not be neglected.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and potential relevance of hyperuricemia in pediatric kidney transplant recipients—a CERTAIN registry analysis

Ehren

Habbig

Krupka

et al. 2022

Pediatric Transplantation

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Background: Asymptomatic hyperuricemia is frequently observed in pediatric kidney transplant recipients; symptomatic hyperuricemia, however, is a rare complication.Only few data are available in this patient population. We, therefore, investigated the prevalence of hyperuricemia and its association with kidney transplant function and blood pressure in a multicenter cohort of pediatric kidney transplant recipients.Methods: This is a retrospective, observational multicenter registry study. All pediatric kidney transplant recipients in the CERTAIN database with at least one documented serum uric acid level and a follow-up of 5 years posttransplant were eligible.

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High urate concentration is associated with elevated blood pressure in schoolchildren

Cited by 11 publications

References 18 publications

Urate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort

Urate and Nonanoate Mark the Relationship between Sugar-Sweetened Beverage Intake and Blood Pressure in Adolescent Girls: A Metabolomics Analysis in the ELEMENT Cohort

Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey

Prevalence and potential relevance of hyperuricemia in pediatric kidney transplant recipients—a CERTAIN registry analysis

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