High uric acid level is a risk factor for progression of IgA nephropathy with chronic kidney disease stage G3a

Moriyama, Takahito; Itabashi, Mitsuyo; Takei, Takashi; Kataoka, Hiroshi; Sato, Masayo; Shimizu, Ari; Iwabuchi, Yuko; Nishida, Miki; Uchida, Keiko; Nitta, Kosaku

doi:10.1007/s40620-014-0154-0

Cited by 32 publications

(22 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, most of these studies have not been adjusted for the renal pathological injuries and treatments. A few recent studies drew inconsistent results [19,20]. Our study also indicated that higher levels of SUA were significantly associated with a higher risk of developing primary outcome or kidney failure, even after adjustment for the confounder factors.…”

Section: Discussionmentioning

confidence: 46%

“…In agreement with the present study, the risk of developing outcome was significantly increased (HR 1.79, 95% CI 1.29-2.49) in the IgAN patients with hyperuricemia as compared with those with normal SUA levels by combining 3 studies enrolling a total of 1,591 patients [31][32][33]. Every 1 mg/24 h higher SUA was associated with a 16% higher risk of developing outcome (HR 1.30, 95% CI 1.13-1.49) by combining the other 2 studies enrolling a total of 1,623 patients [15,20] (online suppl. Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Nagasawa et al [19] suggested that hyperuricemia was an independent risk factor for ESRD in female but not in male IgAN patients. Moriyama et al [20] indicated that hyperuricemia was a risk factor for the progression of IgA nephropathy with CKD stage G3a. Shi et al [21] found a J-shaped association between serum uric acid (SUA) level and ESRD in IgAN patients.…”

Section: Introductionmentioning

confidence: 99%

“…Shi et al [21] found a J-shaped association between serum uric acid (SUA) level and ESRD in IgAN patients. In some of these studies, covariates in association with the progression of IgAN including renal pathological injuries [16,18,19,22] and intervention [20,22] have not been adjusted for.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Uric Acid as a Predictor of Immunoglobulin A Nephropathy Progression: A Cohort Study of 1965 Cases

Zhu

et al. 2018

Am J Nephrol

View full text Add to dashboard Cite

Background: The role of serum uric acid (SUA) level in the progression of Immunoglobulin A nephropathy (IgAN) remains controversial. Methods: In a cohort of 1,965 cases with biopsy-proven IgAN, we examined the associations of SUA concentration with the primary outcome of a composite of all-cause mortality or kidney failure (defined as a reduction of estimated glomerular filtration rate [eGFR] by 40% from baseline, requirements for dialysis and transplantation), or the outcome of kidney failure alone, assessed using Cox and logistic regression models, respectively, with adjustment for confounders. Results: At baseline, the mean age was 33.37 ± 11.07 years, eGFR was 101.30 ± 30.49 mL/min/1.73 m², and mean uric acid level was 5.32 ± 1.76 mg/dL. During a median of 7-year follow-up, 317 cases reached the composite outcome of all-cause mortality (5 deaths) or kidney failure (36 cases of dialysis, 5 cases of renal transplantation, and 271 cases with reduction of eGFR by 40% from baseline). After adjustment for demographic and IgAN specific covariates and treatments, a higher quartile of uric acid was linearly associated with an increased risk of the primary outcome (highest versus lowest quartile, hazard ratio [HR] 2.39; 95% CI 1.52–3.75) and kidney failure (highest versus lowest quartile, HR 2.55; 95% CI 1.62–4.01) in the Cox proportional hazards regression models. In the continuous analysis, a 1 mg/dL greater uric acid level was associated with 16% increased risk of primary outcome (HR 1.16, 95% CI 1.07–1.25) and 17% increased risk of kidney failure (HR 1.17, 95% CI 1.08–1.27), respectively, in the fully adjusted model. The multivariate logistic regression analyses for the sensitive analyses drew consistent results. In the subgroup analyses, significant interactions were detected that patients with mean arterial pressure (MAP) < 90 mm Hg or mesangial hypercellularity had a higher association of SUA with the incidence of the primary outcome than those with MAP ≥90 mm Hg or those without mesangial hypercellularity respectively. Hyperuricemia was not significantly associated with the risk of developing the primary outcome in elder patients (≥32 years old), patients with eGFR < 90 mL/min or with tubular atrophy/interstitial fibrosis. Conclusions: SUA level may be positively associated with the progression of IgAN. It was noticeable that the association of hyperuricemia with IgAN progression was less significant in patients with elder age, lower eGFR, or tubular atrophy/interstitial fibrosis, which may be due to some more confounders in association with the IgA progression in these patients. Future prospective studies are warranted to confirm these findings and to investigate the underlying mechanisms.

show abstract

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Uric Acid as a Predictor of Immunoglobulin A Nephropathy Progression: A Cohort Study of 1965 Cases

Zhu

et al. 2018

Am J Nephrol

View full text Add to dashboard Cite

show abstract

“…In addition, some studies have confirmed that the change in uric acid, citric acid, and creatinine are closely related to antioxidant system and energy metabolism, as well as the biomarker of kidney function. [42][43][44] In this study, the abovementioned biomarker of liver and kidney dysfunction in group PQ2 was alleviated compared with group P (p < 0.05). This result may be explained by the potency of quercetin protective effect against kidney and liver failure by scavenging free radical, enhancing the activity of antioxidant enzymes, downregulating the expression of the fibrotic marker MMP-9, and reducing the peroxidative marker malonaldehyde and inflammatory marker nitric oxide.…”

Section: Discussionmentioning

confidence: 48%

Metabonomic analysis of the protective effect of quercetin on the toxicity induced by mixture of organophosphate pesticides in rat urine

Qı

Cao

et al. 2016

Hum Exp Toxicol

View full text Add to dashboard Cite

The present study aims to investigate the protective effect of quercetin against the joint toxic action induced by the mixture of four organophosphate pesticides (mixture-OPs) (dimethoate, acephate, dichlorvos, and phorate) at their corresponding no observed adverse effect level (NOAEL) using metabonomics. Rats were randomly divided into control, quercetin-treated, mixture-OPs-treated, and quercetin plus mixture-OPs-treated groups. Mixture-OPs and quercetin were given to the rats daily through drinking water and intragastric administration, respectively, for 90 days. The metabonomic profiles of rat urine were analyzed using ultra-performance liquid chromatography–mass spectrometry (UPLC/MS). The 14 metabolites significantly changed in the treatment groups compared with the control group, including the biomarkers of OPs exposure (dimethylphosphate, dimethyldithiophosphate, diethylphosphate) and the metabolites of quercetin (quercetin and isorhamnetina). The intensities of gentisic acid, creatinine, suberic acid, hippuric acid, uric acid, and citric acid significantly decreased, whereas the intensities of 7-methylguanine, estrone sulfate, and cholic acid significantly increased, in the mixture-OPs-treated group compared with the control group ( p < 0.01). The variation tendency of the aforementioned metabolites was significantly ameliorated in the high-dose quercetin (50 mg/(kg bw day)) plus mixture-OPs-treated group compared with the mixture-OPs-treated group ( p < 0.05). However, the intensities of these metabolites in the high-dose quercetin plus mixture-OPs-treated group were still significantly different from those of the control group ( p < 0.05). Results indicated that high dose of quercetin elicits a partial protective effect on the toxicity induced by mixture-OPs, including fatty acid and energy metabolism, antioxidant defense system, DNA damage, and liver and kidney function.

show abstract

An evaluation of the roles of hematuria and uric acid in defining the prognosis of patients with IgA nephropathy

Hogg

2021

Pediatr Nephrol

View full text Add to dashboard Cite

High uric acid level is a risk factor for progression of IgA nephropathy with chronic kidney disease stage G3a

Abstract: H-UA induced global glomerular sclerosis and accelerated the progression of IgAN in CKD stage G3a.

Cited by 32 publications

References 18 publications

Uric Acid as a Predictor of Immunoglobulin A Nephropathy Progression: A Cohort Study of 1965 Cases

Uric Acid as a Predictor of Immunoglobulin A Nephropathy Progression: A Cohort Study of 1965 Cases

Metabonomic analysis of the protective effect of quercetin on the toxicity induced by mixture of organophosphate pesticides in rat urine

An evaluation of the roles of hematuria and uric acid in defining the prognosis of patients with IgA nephropathy

Contact Info

Product

Resources

About