High values of DNA content in the hypotalamic neurons of <i>Lophius piscatorius</i> and <i>Diodon holacanthus</i> (Osteichthyes)

Benedetti, I.; Sassi, D; Mescoli, G.

doi:10.1080/00087114.1998.10589164

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…Computerized image analysis on histological sections treated with Feulgen reaction showed a correlation between the increase in nuclear area of the neurosecretory neurons and the increase in their Feulgen-DNA content. Microfluorimetric analysis on slides treated with ethidium bromide staining demonstrated that the hypothalamic neurons have nuclei whose DNA content increases with an increase in their size, reaching values of about 68C in L. piscatorius and about 84C in D. holacanthus (Benedetti et al 1999). Moreover, the analysis of C values and percent distributions of hypothalamic neuron nuclei suggested that the increase in DNA amounts might be due to differential gene amplification (Benedetti et al 1999).…”

Section: Giant Endopolyploid Neurons Inmentioning

confidence: 98%

“…Teleosts With regard to extra DNA content in teleost neurons, endoreplication phenomena were suggested in the hypothalamic magnocellular neurons in the preoptic and tuberal complexes (Benedetti et al 1999) of the angler fish Lophius piscatorius and in the long-spine porcupinefish Diodon holacanthus. Computerized image analysis on histological sections treated with Feulgen reaction showed a correlation between the increase in nuclear area of the neurosecretory neurons and the increase in their Feulgen-DNA content.…”

Section: Giant Endopolyploid Neurons Inmentioning

confidence: 99%

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Endoreplication: A Molecular Trick during Animal Neuron Evolution

Mandrioli

Mola²,

Cuoghi³

et al. 2010

The Quarterly Review of Biology

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The occurrence of endoreplication has been repeatedly reported in many organisms, including protists, plants, worms, arthropods, molluscs, fishes, and mammals. As a general rule, cells possessing endoreplicated genomes are large-sized and highly metabolically active. Endoreplication has not been frequently reported in neuronal cells that are typically considered to be fully differentiated and non-dividing, and which normally contain a diploid genome. Despite this general statement, various papers indicate that giant neurons in molluscs, as well as supramedullary and hypothalamic magnocellular neurons in fishes, contain DNA amounts larger than 2C. In order to study this issue in greater detail here, we review the available data about endoreplication in invertebrate and vertebrate neurons, and discuss its possible functional significance. As a whole, endoreplication seems to be a sort of molecular trick used by neurons in response to the high functional demands that they experience during evolution.

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Section: Giant Endopolyploid Neurons Inmentioning

confidence: 98%

Section: Giant Endopolyploid Neurons Inmentioning

confidence: 99%

Endoreplication: A Molecular Trick during Animal Neuron Evolution

Mandrioli

Mola²,

Cuoghi³

et al. 2010

The Quarterly Review of Biology

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Morphological, Cytochemical, and Cytofluorimetric Features of Supramedullary Neurons of the Fish Solea ocellata

Cuoghi

Mola²

2007

The Biological Bulletin

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Various teleost species belonging to different orders possess a particular neuronal system formed by giant supramedullary neurons (SNs). In some species, SNs are scattered along the spinal cord; in others they are organized in a compacted and well-defined cluster located at the boundary between the medulla oblongata and spinal cord. In addition to the many morphological, physiological, and histochemical studies performed both in vivo and in vitro by several authors since the end of the 19th century, quantitative microfluorometric evaluation of the DNA content of SNs has showed that clustered SNs but not aligned SNs have a DNA content much greater than the normal value of 2C. Such a high DNA content is exceptional for vertebrate neurons. In the present study, we extend this analysis of SNs to the fish Solea ocellata. Our results show that the organization of the SNs of S. ocellata is neither strictly aligned nor clustered, but somewhere in between, and that this is also true of both their morphological characteristics and DNA content values. Interspecific differences in the distribution and morphology of SNs may reflect functional differences, possibly related to environmental or behavioral differences among species. In addition, the possible functional significance of endoreplication in SNs is discussed.

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High values of DNA content in the hypotalamic neurons of Lophius piscatorius and Diodon holacanthus (Osteichthyes)

Cited by 2 publications

References 17 publications

Endoreplication: A Molecular Trick during Animal Neuron Evolution

Endoreplication: A Molecular Trick during Animal Neuron Evolution

Morphological, Cytochemical, and Cytofluorimetric Features of Supramedullary Neurons of the Fish Solea ocellata

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