High-Viscosity HPMC as a Film-Coating Agent

Abstract

Hydroxypropyl methylcellulose (HPMC)-coated papers without plasticizer and plasticized with polyols were prepared, and the effects of coating weight, different plasticizers (glycerol (GLY), sorbitol (SOR), and polyethylene glycol (PEG)), and plasticizer contents (20% to 50%) on the physical and mechanical properties of the resulting biopolymer-coated papers were studied. Coating weight was the most important factor affecting mechanical properties. Conversely, increasing coating weight led to a decrease in gloss and to an increase in tensile strength (TS), elongation at break (%E), and tearing resistance of coated papers. The application of unplasticized HPMC coatings (3 g/m 2) on paper reduced water vapor permeability (WVP) and water absorption capacity by 25% as compared with uncoated paper. All plasticizers significantly (p < 0.05) increased WVP and Cobb 60 values of the films. With the exception of PEG, no effect was found with plasticizers on TS and %E of coated papers compared with those without plasticizer. HPMC-coated papers with PEG as a plasticizer showed significantly lower TS and higher %E and tearing resistance than the other plasticized films (p < 0.05). HPMC coating improved tensile properties and tearing resistance of paper and could be regarded as a reinforcement layer.

A Novel Injection-Molded Capsular Device for Oral Pulsatile Delivery Based on Swellable/Erodible Polymers

“…The Chronotopic™ system is a swellable/erodible device based on hydrophilic cellulose derivatives, typically hydroxypropyl methylcellulose (HPMC), as the releasecontrolling agent and on tablet, gelatin capsule, or multiple units (mini-tablets, pellets) as the drug core (11)(12)(13)(14)(15). Its ability to yield reproducible lag phases prior to release was demonstrated both in vitro and in vivo on healthy volunteers.…”

Time-Based Formulation Strategies for Colon Drug Delivery

“…Moreover, it poses limitations in the design flexibility owing to the large amount of coating polymer needed. Thus, the feasibility of spray-coating was explored [57][58][59]. Medium-and high-viscosity HPMC grades had never been used before as coating agents.…”

“…Indeed, a good correlation was found between weight gain and lag time. When in vitro testing was carried out in media having different pH (1.2-6.8) and ionic strength (0.01-0.60) values, consistent lag phases were achieved regardless of such variables in their physiological ranges Thus, the feasibility of spray-coating was explored [57][58][59]. Medium-and highviscosity HPMC grades had never been used before as coating agents.…”

“…However, such a manufacturing technique was poorly fit for large-scale production due to the use of organic solvents. Thus, the feasibility of spray-coating was explored [57][58][59]. Medium-and high-viscosity HPMC grades had never been used before as coating agents.…”