High vitamin intake by Wistar rats during pregnancy alters tissue fatty acid concentration in the offspring fed an obesogenic diet

Reza-López, Sandra A.; Anderson, G. Harvey; Szeto, Ignatius Man Yau; Taha, Ameer Y.; W.L., David

doi:10.1016/j.metabol.2009.01.014

Cited by 16 publications

(5 citation statements)

References 70 publications

(81 reference statements)

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“…In the latter study, maternal-obesity-induced oxidative imbalance was restored when Western-diet-fed dams received a mixture of antioxidant supplement, and that benefit in offspring was a decrease in adiposity [12]. The type of vitamin supplement obviously is critical because others have reported increase in adiposity in young rats fed an obesogenic diet when dams received excessive amount of vitamin during pregnancy [13].…”

Section: Introductionmentioning

confidence: 91%

Maternal green tea extract supplementation to rats fed a high-fat diet ameliorates insulin resistance in adult male offspring

Tse

2012

The Journal of Nutritional Biochemistry

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Section: Introductionmentioning

confidence: 91%

Maternal green tea extract supplementation to rats fed a high-fat diet ameliorates insulin resistance in adult male offspring

Tse

2012

The Journal of Nutritional Biochemistry

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“…Hyperglycemia in female offspring was not as significant as those in male offspring. Considering the sex dimorphism that has been reported in other studies 39,40 . Potential hormonally related differences or other factors that may obscure the overall phenotype, it is worthwhile to identify the difference between male and female mice.…”

Section: Discussionmentioning

confidence: 98%

“…Considering the sex dimorphism that has been reported in other studies. 39,40 Potential hormonally related differences or other factors that may obscure the overall phenotype, it is worthwhile to identify the difference between male and female mice. Furthermore, lots of factors can influence DNA methylation, includes histone modification, noncoding RNA, and so on.…”

Section: Discussionmentioning

confidence: 99%

Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets

Zeng

Zhang

Liang

et al. 2023

Journal of Pineal Research

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Diabetes and metabolic perturbation are global health challenges. Sleep insufficiency may trigger metabolic dysregulation leading to diabetes. However, the intergenerational transmission of this environmental information is not clearly understood. The research objective was to determine the possible effect of paternal sleep deprivation on the metabolic phenotype of the offspring and to investigate the underlying mechanism of epigenetic inheritance. Male offspring of sleep‐deprived fathers exhibit glucose intolerance, insulin resistance, and impaired insulin secretion. In these SD‐F1 offspring, a reduction in beta cell mass and proliferation of beta cells were observed. Mechanistically, in pancreatic islets of SD‐F1 offspring, we identified alterations in DNA methylation at the promoter region of the LRP5 (LDL receptor related protein 5) gene, a coreceptor of Wnt signaling, resulting in downregulation of downstream effectors cyclin D1, cyclin D2, and Ctnnb1. Restoration of Lrp5 in the pancreas of SD‐F1 male mice could improve impaired glucose tolerance and expression of cyclin D1, cyclin D2, and Ctnnb1. This study might significantly contribute to our understanding of the effects of sleeplessness on health and metabolic disease risk from the perspective of the heritable epigenome.

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“…These results are consistent with studies showing that male rats are more susceptible to manipulation in gestational diets, [24][25][26] possibly because of their faster growth rate and higher nutrient demands than females. 3,27 In addition, males, but not females, born to HV dams had higher concentration of saturates and monounsaturates, higher total fat in muscle and higher n-6 to n-3 fatty acids ratio in muscle in early adulthood, 28 suggesting that males would develop insulin resistance earlier in life than females. In our previous study, female rats born to HV dams developed characteristics of metabolic syndrome only when they were weaned to an obesogenic diet, 12 but not to a regular AIN-93G powdered diet.…”

Section: Discussionmentioning

confidence: 99%

The effect of high multivitamin diet during pregnancy on food intake and glucose metabolism in Wistar rat offspring fed low-vitamin diets post weaning

Szeto

Huot

Reza-López

et al. 2011

J Dev Orig Health Dis

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Rat offspring born to dams fed a high multivitamin diet (HV) are shown to have increased risks of obesity and metabolic syndrome. We hypothesized that a low-vitamin postweaning diet would enhance these characteristics in offspring born to HV dams. During pregnancy, Wistar rats were fed the AIN-93G diet with or without a 10-fold increase in vitamin content. In Experiment 1, at weaning, males were fed the recommended diet (RV) or a diet with 1/3 the vitamin content (1/3 RV) for 12 weeks. In Experiment 2, males and females were fed the RV diet or 1/6 RV diet for 35 weeks. Body weight was measured on a weekly basis, food intake on a daily basis, and for 1 h after an overnight fast following glucose gavage at 6, 12 and 24 weeks. Blood glucose and insulin responses to an oral glucose load were measured at 30 weeks. Males from HV dams, compared with those from RV dams, gained more weight in Experiment 1 (+7%, P < 0.05) and Experiment 2 (+11%, P < 0.0001), along with higher glucose response (+33%, P < 0.05). The 1/6 RV pup diet led to lower weight gain in males (-16%, P < 0.0001) and females (-13%, P < 0.0005), and lower food intake in males (-9%, P < 0.01) independent of the gestational diet. Females on the 1/6 RV diet and from HV dams had higher 1 h food intake (+36%, P < 0.05) and lower insulin response (-25%, P < 0.05) compared with those from RV dams. Exposure of the offspring to low-vitamin diets did not amplify the expression of the metabolic syndrome observed in those born to dams fed an HV diet.

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High vitamin intake by Wistar rats during pregnancy alters tissue fatty acid concentration in the offspring fed an obesogenic diet

Cited by 16 publications

References 70 publications

Maternal green tea extract supplementation to rats fed a high-fat diet ameliorates insulin resistance in adult male offspring

Maternal green tea extract supplementation to rats fed a high-fat diet ameliorates insulin resistance in adult male offspring

Paternal sleep deprivation induces metabolic perturbations in male offspring via altered LRP5 DNA methylation of pancreatic islets

The effect of high multivitamin diet during pregnancy on food intake and glucose metabolism in Wistar rat offspring fed low-vitamin diets post weaning

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