Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged ≥60 y

Abstract

In both active and inactive ambulatory persons aged > or =60 y, 25(OH)D concentrations between 40 and 94 nmol/L are associated with better musculoskeletal function in the lower extremities than are concentrations < 40 nmol/L.

Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS study

“…(1)(2)(3) Indeed, there is increasing evidence that when accounting not for skeletal health but the salutary effects of vitamin D on nonskeletal organs, the optimal health-promoting concentration of 25(OH)D is around 30 ng/mL. (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) In particular, adverse neuromuscular events such as muscle weakness, balance impairment, and reduced nerve conduction have been described for serum 25(OH)D concentrations below 30 ng/mL. (3)(4)(5)(6)(7)(8)(9)(10)(11) Walking speed is a simple, objective performance-based measure of lower limb neuromuscular function that not only allows detection of subtle impairments and preclinical diseases but also is a sensitive marker of functional capacity in older adults.…”

“…(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) In particular, adverse neuromuscular events such as muscle weakness, balance impairment, and reduced nerve conduction have been described for serum 25(OH)D concentrations below 30 ng/mL. (3)(4)(5)(6)(7)(8)(9)(10)(11) Walking speed is a simple, objective performance-based measure of lower limb neuromuscular function that not only allows detection of subtle impairments and preclinical diseases but also is a sensitive marker of functional capacity in older adults. (10)(11)(12)(13)(14)(15)(16) For instance, Suzuki and colleagues recently demonstrated that walking speed in older adults was positively ORIGINAL ARTICLE J JBMR correlated with physical performance tests such as handgrip strength or stork standing time.…”

“…(3)(4)(5)(6)(7)(8)(9)(10)(11) Walking speed is a simple, objective performance-based measure of lower limb neuromuscular function that not only allows detection of subtle impairments and preclinical diseases but also is a sensitive marker of functional capacity in older adults. (10)(11)(12)(13)(14)(15)(16) For instance, Suzuki and colleagues recently demonstrated that walking speed in older adults was positively ORIGINAL ARTICLE J JBMR correlated with physical performance tests such as handgrip strength or stork standing time. (16) Furthermore, these authors also found a significant positive association between walking speed at a usual pace and serum 25(OH)D concentrations.…”

“…(16) Compared with muscle strength or balance performance, (5)(6)(7) fewer attempts have been made to explore the association between low chronic serum 25(OH)D concentrations and walking speed. (10,(16)(17)(18)(19)(20)(21)(22) A better understanding of this association is important to further develop interventional clinical studies to assess the effect of vitamin D supplementation on mobility and gait performance and related adverse health consequences. Previous studies showed conflicting results because some of them found a significant positive association, (10,(16)(17)(18)(19)(20) whereas others did not.…”

“…(10,(16)(17)(18)(19)(20)(21)(22) A better understanding of this association is important to further develop interventional clinical studies to assess the effect of vitamin D supplementation on mobility and gait performance and related adverse health consequences. Previous studies showed conflicting results because some of them found a significant positive association, (10,(16)(17)(18)(19)(20) whereas others did not. (21,22) These differences may be related, in part, to the type of walking speed measured.…”