Higher adherence to the Mediterranean diet is associated with lower levels of D-dimer: findings from the MOLI-SANI study

Castelnuovo, Augusto Di; Bonaccio, Marialaura; Curtis, Amalia De; Costanzo, Simona; Persichillo, Mariarosaria; Gaetano, Giovanni de; Donati, Maria Benedetta; Iacoviello, Licia; Investigators, Moli-sani Study

doi:10.3324/haematol.2016.156331

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…In addition, the MedDiet capacity to decrease plasma levels of inflammatory biomarkers may help explain the reduction in the concentrations of pro-inflammatory molecules bound to HDL particles [15] . This decrease in low-grade inflammation could also contribute to explaining the enhancement of other pro-thrombotic signals (the decrease in D-dimer levels after the MedDiet intervention among users of antithrombotic drugs agrees with previous cross-sectional evidence [17] ). In relation to NEFAs, they promote endothelial stress and platelet aggregation and are considered an emergent pro-thrombotic risk factor in high cardiovascular risk states such as obesity and hypertriglyceridemia [13] .…”

Section: Discussionsupporting

confidence: 87%

“…In the context of the PREDIMED ( Prevención con Dieta Mediterránea) trial, following a MedDiet decreased P-selectin levels [15] . Beyond this study, only a small-scale prospective analysis with 21 young, healthy male volunteers indicated that following a MedDiet-like dietary pattern was related to lower fibrinogen levels and an attenuation of the coagulation response [16] , and two cross-sectional studies have reported associations between MedDiet adherence and less D-dimer and fibrinogen values [17,18] . However, no intervention trial has studied the long-term effects of this healthy dietary pattern on a comprehensive set of biomarkers of atherothrombosis to date.…”

Section: Introductionmentioning

confidence: 99%

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Mediterranean Diet and atherothrombosis biomarkers: a randomized controlled trial

Hernáez

Castañer

Tresserra‐Rimbau

et al. 2019

Preprint

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Scope. To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals. Methods and results. In 358 random volunteers from the PREDIMED trial (Prevencion con Dieta Mediterranea), we assessed the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; N=120) or nuts (MedDiet-Nuts; N=119) versus a low-fat control diet (N=119). In a secondary, observational approach, we studied whether volunteers with large increments in MedDiet adherence (>2 score points) were associated with 1-year improvements in biomarkers (relative to those worsening their adherence). The MedDiet-VOO intervention increased platelet activating factor-acetylhydrolase activity in high-density lipoproteins (HDLs) by 7.5% [95% confidence interval: 0.17; 14.8] and decreased HDL-bound α1-antitrypsin levels by 6.1% [-11.8; -0.29]. The MedDiet-Nuts one reduced non-esterified fatty acid concentrations by 9.3% [-18.1; -0.53]. Only the low-fat diet was associated with increases in platelet factor-4 and prothrombin factor1+2 levels versus baseline (P=0.012 and P=0.003, respectively, according to Wilcoxon signed-rank tests). Finally, large MedDiet increments were associated with less fibrinogen (-9.5% [-18.3; -0.60]) and non-esterified fatty acid concentrations (-16.7% [-31.7; -1.74]). Conclusion. Following a MedDiet improves atherothrombosis biomarkers in high cardiovascular risk individuals.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet and atherothrombosis biomarkers: a randomized controlled trial

Hernáez

Castañer

Tresserra‐Rimbau

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…[ 24 ] In addition, following a MedDiet has also been associated with decreased levels of pro‐inflammatory molecules in circulation. [ 16 ] This fact could contribute to explaining the reduction in the concentrations of pro‐inflammatory molecules bound to HDL particles, as well as improvements in other pro‐thrombotic signals (the decrease in d ‐dimer levels after the MedDiet intervention among users of antithrombotic drugs and the association between substantial increments in MedDiet adherence and lower concentrations of fibrinogen, both consistent with previous evidence [ 18,19 ] ). In parallel, to explain the association between the MedDiet‐Nuts intervention and lower NEFA levels, we hypothesize that polyunsaturated fatty acids (whose intake was particularly increased in this group, especially non‐marine omega‐3 fatty acids whose intake increased by 1.15 g per day) bind to G‐protein coupled receptor 120 receptors in adipose tissue, reduce lipolysis, and decrease the circulating levels of free fatty acids.…”

Section: Discussionsupporting

confidence: 82%

“…[ 16 ] Beyond this study, only a small‐scale prospective analysis with 21 young, healthy male volunteers indicated that following a MedDiet‐like dietary pattern was related to lower fibrinogen levels and an attenuation of the coagulation response, [ 17 ] and two cross‐sectional studies have reported associations between MedDiet adherence and less d ‐dimer and fibrinogen values. [ 18,19 ] However, no intervention trial has studied to date the long‐term effects of this healthy dietary pattern on a comprehensive set of biomarkers of atherothrombosis.…”

Section: Introductionmentioning

confidence: 99%

Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial

Hernáez

Castañer

Tresserra‐Rimbau

et al. 2020

Molecular Nutrition Food Res

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Scope: To assess whether following a Mediterranean diet (MedDiet) improves atherothrombosis biomarkers in high cardiovascular risk individuals. Methods and results: In 358 random volunteers from the PREvención con DIeta MEDiterránea trial, the 1-year effects on atherothrombosis markers of an intervention with MedDiet, enriched with virgin olive oil (MedDiet-VOO; n = 120) or nuts (MedDiet-Nuts; n = 119) versus a low-fat control diet (n = 119), and whether large increments in MedDiet adherence (≥3 score points, versus compliance decreases) and intake changes in key food items are associated with 1-year differences in biomarkers. Differences are observed between 1-year changes in the MedDiet-VOO intervention and control diet on the activity of platelet activating factor acetylhydrolase in high-density lipoproteins (HDLs) (+7.5% [95% confidence interval: 0.17; 14.8]) and HDL-bound 1-antitrypsin levels (−6.1% [−11.8; −0.29]), and between the MedDiet-Nuts intervention and the control arm on non-esterified fatty acid concentrations (−9.3% [−18.1; −0.53]). Large MedDiet adherence increments are associated with less fibrinogen (−9.5% [−18.3; −0.60]) and non-esterified fatty acid concentrations (−16.7% [−31.7; −1.74]). Increases in nut, fruit, vegetable, and fatty fish consumption, and decreases in processed meat intake are linked to enhancements in biomarkers. Conclusion: MedDiet improves atherothrombosis biomarkers in high cardiovascular risk individuals.

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Unhealthy lifestyle habits and diabetes-specific health-related quality of life in youths with type 1 diabetes

et al. 2017

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Higher adherence to the Mediterranean diet is associated with lower levels of D-dimer: findings from the MOLI-SANI study

Cited by 3 publications

References 14 publications

Mediterranean Diet and atherothrombosis biomarkers: a randomized controlled trial

Mediterranean Diet and atherothrombosis biomarkers: a randomized controlled trial

Mediterranean Diet and Atherothrombosis Biomarkers: A Randomized Controlled Trial

Unhealthy lifestyle habits and diabetes-specific health-related quality of life in youths with type 1 diabetes

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