Higher alveolar deposition of particulate matter in emphysematous lobes of COPD

Tùng, Nguyễn Thanh; Ho, Shu-Chuan; Lu, Yueh‐Hsun; Chen, Tzu-Tao; Lee, Kang‐Yun; Chen, Kuan-Yuan; Wu, Chih-Da; Chung, Kian Fan; Kuo, Han‐Pin; Thao, Huynh Nguyen Xuan; Dung, Hoang Ba; Thuy, Tran Phan Chung; Wu, Sheng‐Ming; Kou, Hsiao-Yun; Lee, Yueh-Lun; Chuang, Hsiao-Chi

doi:10.1183/23120541.00324-2021

Cited by 4 publications

(3 citation statements)

References 18 publications

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“…In this study, we observed that an increase in PM 2.5 , NO 2 , and O 3 was associated with greater increases in upper lobe LAA than in lower lobe LAA. This was consistent with a previous study showing that PM 2.5 deposition was associated with higher emphysema severity in upper lobes than in lower lobes ( 61 ). This suggested that upper lobes might be preferentially impacted by air pollution than lower lobes.…”

Section: Discussionsupporting

confidence: 94%

“…Our results further showed that air pollution was associated with lobar emphysema, especially in the upper lobes, by PM 2.5 , NO 2 , and O 3 . Our previous study found that a 1 μg/m 3 increase in PM 2.5 deposition in each lung lobe was associated with increases in %LAA (beta coefficient) of the same lung lobe ( p < 0.05) ( 61 ). Because of particle physicochemical characteristics, lung geometric difference, and breathing pattern, the associations between air pollutants with lung lobe percent emphysema could be associated with our findings.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Air Pollution and Lung Lobar Emphysema in COPD

Tùng

et al. 2021

Front. Med.

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The development of emphysema has been linked to air pollution; however, the association of air pollution with the extent of lobar emphysema remains unclear. This study examined the association of particulate matter <2.5 μm in aerodynamic diameters (PM2.5) (≤2.5 μm), nitrogen dioxide (NO2), and ozone (O3) level of exposure with the presence of emphysema in 86 patients with chronic obstructive pulmonary disease (COPD). Exposure to the air pollution estimated using the land-use regression model was associated with lung function, BODE (a body mass index, degree of obstruction, dyspnea severity, and exercise capacity index) quartiles, and emphysema measured as low-attenuation areas on high-resolution CT (HR-CT) lung scans. Using paraseptal emphysema as the reference group, we observed that a 1 ppb increase in O3 was associated with a 1.798-fold increased crude odds ratio of panlobular emphysema (p < 0.05). We observed that PM2.5 was associated with BODE quartiles, modified Medical Research Council (mMRC) dyspnea score, and exercise capacity (all p < 0.05). We found that PM2.5, NO2, and O3 were associated with an increased degree of upper lobe emphysema and lower lobe emphysema (all p < 0.05). Furthermore, we observed that an increase in PM2.5, NO2, and O3 was associated with greater increases in upper lobe emphysema than in lower lobe emphysema. In conclusion, exposure to O3 can be associated with a higher risk of panlobular emphysema than paraseptal emphysema in patients with COPD. Emphysema severity in lung lobes, especially the upper lobes, may be linked to air pollution exposure in COPD.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Association Between Air Pollution and Lung Lobar Emphysema in COPD

Tùng

et al. 2021

Front. Med.

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“…Although air pollution variables appear to correlate well with the increased COPD prevalence and declining pulmonary function [39][40][41], less is known about the association with O 2 desaturation during exercise in emphysematous patients. Our previous study found that air pollution (PM 2.5 , NO 2 , and O 3 ) was associated with lobar emphysema, especially in the upper lobes (p < 0.05) [42]. PM 2.5 can penetrate deeply into the lungs and destroy alveolar septa by generating excessive reactive oxygen species (ROS) [43].…”

Section: Discussionmentioning

confidence: 99%

Association of air pollution exposure with exercise-induced oxygen desaturation in COPD

Lee

Kou

et al. 2022

Respir Res

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Background There is a link between exposure to air pollution and the increased prevalence of chronic obstructive pulmonary disease (COPD) and declining pulmonary function, but the association with O2 desaturation during exercise in COPD patients with emphysema is unclear. Our aims were to estimate the prevalence of O2 desaturation during exercise in patients with COPD, and determine the association of exposure to air pollution with exercise-induced desaturation (EID), the degree of emphysema, and dynamic hyperinflation (DH). Methods We assessed the effects of 10-year prior to the HRCT assessment and 7 days prior to the six-minute walking test exposure to particulate matter with an aerodynamic diameter of < 10 µm (PM10) or of < 2.5 µM (PM2.5), nitrogen dioxide (NO2), and ozone (O3) in patients with emphysema in this retrospective cohort study. EID was defined as a nadir standard pulse oximetry (SpO2) level of < 90% or a delta (△)SpO2 level of ≥ 4%. Ambient air pollutant (PM2.5, PM10, O3, and NO2) data were obtained from Taiwan Environmental Protection Administration (EPA) air-monitoring stations, usually within 10 km to each participant’s home address. Results We recruited 141 subjects with emphysema. 41.1% of patients with emphysema exhibited EID, and patients with EID had more dyspnea, worse lung function, more severe emphysema, more frequent acute exacerbations, managed a shorter walking distance, had DH, and greater long-term exposure to air pollution than those without EID. We observed that levels of 10-year concentrations of PM10, PM2.5, and NO2 were significantly associated with EID, PM10 and PM2.5 were associated with the severity of emphysema, and associated with DH in patients with emphysema. In contrast, short-term exposure did not have any effect on patients. Conclusion Long-term exposure to ambient PM10, PM2.5 and NO2, but not O3, was associated with EID.

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Climate-mediated air pollution associated with COPD severity

Tran

Chen

et al. 2022

Science of The Total Environment

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Higher alveolar deposition of particulate matter in emphysematous lobes of COPD

Cited by 4 publications

References 18 publications

Association Between Air Pollution and Lung Lobar Emphysema in COPD

Association Between Air Pollution and Lung Lobar Emphysema in COPD

Association of air pollution exposure with exercise-induced oxygen desaturation in COPD

Climate-mediated air pollution associated with COPD severity

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