Higher Body Mass Index Increases the Risk for Biopsy-Mediated Detection of Prostate Cancer in Chinese Men

Abstract

ObjectiveTo investigate the relationship between body mass index (BMI) and prostate cancer (PCa) risk at biopsy in Chinese men.Patients and MethodsWe retrospectively reviewed the records of 1,807 consecutive men who underwent initial multicore (≥10) prostate biopsy under transrectal ultrasound guidance between Dec 2004 and Feb 2014. BMI was categorised based on the Asian classification of obesity as follows: <18.5 (underweight), 18.5–22.9 (normal weight), 23–24.9 (overweight), 25–29.9 (moderately obese), and ≥30 kg/m2 (severely obese). The odds ratios (OR) of each BMI category for risk of PCa and high-grade prostate cancer (HGPCa, Gleason score ≥4+3) detection were estimated in crude, age-adjusted and multivariate-adjusted models. Prevalence ratios and accuracies of PSA predicted PCa were also estimated across BMI groups.ResultsIn total, PCa was detected by biopsy in 750 (45.4%) men, and HGPCa was detected in 419 (25.4%) men. Compared with men of normal weight, underweight men and obese men were older and had higher prostate specific antigen levels. The risk of overall PCa detection via biopsy presented an obvious U-shaped relationship with BMI in crude analysis. Overall, 50.0%, 37.4%, 45.6% 54.4% and 74.1% of the men in the underweight, normal weight, overweight, moderately obese and severely obese groups, respectively, were diagnosed with PCa via biopsy. In multivariate analysis, obesity was significantly correlated with a higher risk of PCa detection (OR = 1.17, 95%CI 1.10–1.25, P<0.001). However, higher BMI was not correlated with HGPCa detection (OR = 1.03, 95%CI 0.97–1.09, P = 0.29). There were no significant differences in the accuracy of using PSA to predict PCa or HGPCa detection across different BMI categories.ConclusionObesity was associated with higher risk of PCa detection in the present Chinese biopsy population. No significant association was detected between obesity and HGPCa.

Waist-hip Ratio (WHR), a Better Predictor for Prostate Cancer than Body Mass Index (BMI): Results from a Chinese Hospital-based Biopsy Cohort

“…One recent study considered the fact that BMI values in Asians are lower than in Western counterparts and thus used a BMI cut-off of 25 kg/m 2 to define obesity. In doing so, they found that higher BMI was linked with increased risk of PCa at biopsy, however no significant association was seen between obesity and HGPCa8. A recent report also found that Asian men with a BMI ≥25 kg/m 2 were at a higher risk of having PCa at initial biopsy9, confirming that indeed obesity may be associated with higher risk of total PCa, although the associations between obesity and PCa grade among Asian men are still unclear.…”

Obese asthmatics are characterized by altered adipose tissue macrophage activation

“…This observation is consistent with previous reports utilizing immunohistochemistry 18 and FACS. 19 Increased BMI is considered as a strong and independent predictor of obesity- | 645 associated comorbidities, [19][20][21] including asthma. 22,23 In several other disease states, the negative end-organ effects of obesity are recognized to be a consequence of higher pro-inflammatory activity of the visceral fat depot, compared to the subcutaneous fat depot, 24 with ATMs having a pivotal role.…”

Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells

“…The prevalence of prostate cancer differs from one country to another due to coverage of prostate-specific antigen screening [ 2 ]. In China, the rate of prostate cancer is rapidly increasing and especially in patients with obesity or diabetes [ 3 , 4 ]. As androgen receptor plays an important role in the pathogenesis of prostate cancer, androgen-deprivation therapy remains the principal method for treatment of patients with prostate cancer [ 5 ].…”