Obese asthmatics are characterized by altered adipose tissue macrophage activation

Periyalil, Hashim A.; Wood, Lisa G.; Wright, Timothy; Karihaloo, Constantine; Starkey, Malcolm R.; MIu, Alekseev; Baines, Katherine J.; Hansbro, Philip M.; Gibson, Peter G.

doi:10.1111/cea.13109

Cited by 52 publications

(29 citation statements)

References 45 publications

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“…Subjects were pooled from seven previously published research studies [25,[27][28][29][30][31]. Subjects were adults (≥18 years of age) with (n = 255) and without (n = 137) asthma, recruited at the Hunter Medical Research Institute (HMRI), NSW Australia, from existing research volunteer databases or by media release.…”

Section: Subjectsmentioning

confidence: 99%

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

et al. 2019

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Asthma is a chronic inflammatory airway disease, associated with systemic inflammation. Omega-3 polyunsaturated fatty acids (n-3 PUFA) have established anti-inflammatory effects, thus having potential as an adjunct therapy in asthma. This study aimed to compare erythrocyte n-3 PUFA in adults with (n = 255) and without (n = 137) asthma and determine the relationship between erythrocyte n-3 PUFA and clinical asthma outcomes. Subjects had blood collected, lung function measured and Juniper Asthma Control Questionnaire (ACQ) score calculated. Fatty acids were measured in erythrocyte membranes by gas chromatography, and the omega-3 index (O3I) was calculated (% eicosapentaenoic acid + % docosahexaenoic acid). O3I was similar in subjects with and without asthma (p = 0.089). A higher O3I was observed in subjects with controlled or partially controlled asthma (ACQ < 1.5) compared to subjects with uncontrolled asthma (ACQ ≥ 1.5) (6.0% (5.4–7.2) versus 5.6% (4.6–6.4) p = 0.033). Subjects with a high O3I (≥8%) had a lower maintenance dose of inhaled corticosteroids (ICS) compared to those with a low O3I (<8%) (1000 μg (400–1000) versus 1000 μg (500–2000) p = 0.019). This study demonstrates that a higher O3I is associated with better asthma control and with lower ICS dose, suggesting that a higher erythrocyte n-3 PUFA level may have a role in asthma management.

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Section: Subjectsmentioning

confidence: 99%

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

et al. 2019

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“…This kind of diet usually includes foods rich in calories and their regular consumption can lead to overweight and obesity, which basically consists of an excess of body-fat stores. This adipose tissue seems to be an important factor in systemic inflammation, including airway inflammation (asthma), and especially in the case of obesity, which is characterized by excessive accumulation of fat [2]. From this perspective, this review examines the evidence for the association between asthma and nutrition, and specifically addresses the effect of Western diets on the inflammatory processes, reviewing the causative relationships with the adipose tissue.…”

Section: Introductionmentioning

confidence: 99%

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Frontela‐Saseta

González-Bermúdez

García‐Marcos

2020

JCM

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The Western lifestyle is a complex concept that includes the diet as the main axis of different factors which contribute to a detrimental effect on health, lower life expectancy and low quality-of-life. This type of diet is characterized by being high in calories, mainly provided by saturated fats, and rich in sugars that can lead to changes in immune cells and their responsiveness, by different mechanisms that have yet to be totally clarified. Inflammatory processes are perpetuated through different pathways, in which adipose tissue is a major factor. High fat stores in overweight and obesity accumulate energy but the endocrine function is also producing and releasing different bioactive compounds, adipokines, known to be pro-inflammatory and which play an important role in the pathogenesis of asthma. This review therefore explores the latest evidence regarding the adverse effect of the Western diet on adipose tissue inflammation and its causative effect on the asthma epidemic.

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“…The macrophages of fatty tissue are significantly elevated and mediate both local and systemic inflammation, leading to the recruitment and activation of type 1 T-helper cells [ 9 , 38 , 39 , 40 ]. Their activation enhances the immune response by producing additional pro-inﬂammatory cytokines and inflammatory markers such as TNF-α, IL-8 and IL-6, highly sensitive C-reactive protein (hs-CRP) and monocytic chemoattractive protein-1 (MCP-1) [ 41 , 42 , 43 , 44 ].…”

Section: Inflammation Pattern In Obesity-associated Asthmamentioning

confidence: 99%

Obesity-associated asthma in childhood

Mangova¹,

Lipek²,

Hove³

et al. 2020

ALS

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Obesity and bronchial asthma are very common diseases in children and adolescents, associated with a considerable burden of disease, reduced quality of life and comorbidities. Obesity is a significant risk factor for bronchial asthma. On the one hand, obesity leads to changes in the mechanics and function of the lungs and chest. On the other hand, obesity-associated inflammatory processes with increased production of leptin and cytokines may trigger bronchial inflammation with the appearance of asthmatic symptoms. The diseases are also linked by genetic factors. Physical activity and weight reduction have a significant benefit. Pharmacotherapy must be based on the pattern of inflammation. This article summarizes the current state of the literature on the association of asthma and obesity and presents current and possible future treatment options.

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Obese asthmatics are characterized by altered adipose tissue macrophage activation

Abstract: Visceral inflammation with increased pro-inflammatory macrophages (M1) occurs in obese asthma and may be a determinant of systemic inflammation and asthma severity.

Cited by 52 publications

References 45 publications

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

Higher Omega-3 Index Is Associated with Better Asthma Control and Lower Medication Dose: A Cross-Sectional Study

Diet: A Specific Part of the Western Lifestyle Pack in the Asthma Epidemic

Obesity-associated asthma in childhood

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