Higher concentration of selenium in placental tissues is associated with reduced risk for orofacial clefts

Pi, Xin; Wei, Yihui; Li, Zhiwen; Jin, Lei; Liu, Jufen; Zhang, Yali; Ren, Aiguo

doi:10.1016/j.clnu.2018.11.002

Cited by 12 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Selenium is essential for antioxidant enzyme activities and normal fetal development [ 45 ]. Selenium deficiency in pregnancy might contribute to congenital anomalies, including neural tube defects and orofacial clefts [ 46 , 47 , 48 ]. Selenium exposure was reported to be associated with the changes in epigenetic patterning in both human and animal studies [ 49 , 50 ], which may exert effects on fetal cardiovascular development.…”

Section: Discussionmentioning

confidence: 99%

Maternal Zinc, Copper, and Selenium Intakes during Pregnancy and Congenital Heart Defects

et al. 2022

View full text Add to dashboard Cite

The effects of zinc, copper, and selenium on human congenital heart defects (CHDs) remain unclear. This study aimed to investigate the associations of the maternal total, dietary, and supplemental intakes of zinc, copper, and selenium during pregnancy with CHDs. A hospital-based case-control study was performed, including 474 cases and 948 controls in Northwest China. Eligible participants waiting for delivery were interviewed to report their diets and characteristics in pregnancy. Mixed logistic regression was adopted to examine associations and interactions between maternal intakes and CHDs. Higher total intakes of zinc, selenium, zinc to copper ratio, and selenium to copper ratio during pregnancy were associated with lower risks of total CHDs and the subtypes, and the tests for trend were significant (all p < 0.05). The significantly inverse associations with CHDs were also observed for dietary intakes of zinc, selenium, zinc to copper ratio, selenium to copper ratio, and zinc and selenium supplements use during pregnancy and in the first trimester. Moreover, high zinc and high selenium, even with low or high copper, showed a significantly reduced risk of total CHDs. Efforts to promote zinc and selenium intakes during pregnancy need to be strengthened to reduce the incidence of CHDs in the Chinese population.

show abstract

Section: Discussionmentioning

confidence: 99%

Maternal Zinc, Copper, and Selenium Intakes during Pregnancy and Congenital Heart Defects

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The samples were shipped with dry ice to our laboratory for storage at − 20°C prior to processing. The details of sample preparation have been described elsewhere [25] . Shortly after thawing at 4°C, about 6 g specimens on the fetal side were collected within 3 cm around the insertion point of the umbilical cord, rinsed with deionized water, and freeze-dried 24 h (ALPHA2-4 LD plus, Christ, Germany).…”

Section: Placenta Collection and Metal Quanti Cationmentioning

confidence: 99%

Prenatal exposure to silver is associated with an elevated risk for neural tube defects: a case–control study

Wang

et al. 2022

Environ Sci Pollut Res

Self Cite

View full text Add to dashboard Cite

Background: Exposure to copper, silver, and titanium has been reported to be associated with a variety of adverse effects on humans. However, few studies have focused on the fetus, which is vulnerable to environmental insults. We investigated the associations between prenatal exposure to the three metals and risk for fetal neural tube defects (NTDs).Methods: Placental samples from 408 women with pregnancies affected by NTDs and 593 women with normal pregnancies were collected from 2003 to 2016 in an NTD high-risk area in northern China. Placental metal concentrations were quanti ed and used as prenatal exposure markers. Multilevel mixedeffects logistic regression was used to estimate the odds ratio (OR) and 95% con dence interval (CI) for the association between metal concentrations and risk for NTDs. Single and joint effects of the metals on NTDs were evaluated with Bayesian kernel machine regression (BKMR), which can account for correlation, nonlinearity, and interaction between metals.Results: NTDs had higher concentrations of copper (4.16 μg/g) and silver (0.96 ng/g) than controls (copper: 3.91 μg/g; silver: 0.96 ng/g). Silver was associated with an increased risk for NTDs in a doseresponse fashion in single-metal logistic regression, with adjusted ORs (95% CIs) of 1.78 (1.04-3.06) and 1.92 (1.11-3.32) in the second and third tertiles, respectively, compared to the lowest tertile. BKMR revealed toxic effects of silver on NTDs when the concentrations of copper and titanium were xed at their 25 th , 50 th , and 75 th percentiles, and the association appeared to be linear. No interaction of silver with any of the other two metals was observed. Besides, silver concentration was positively correlated with maternal certain dietary intakes, such as meat or sh, during the periconceptional period.Conclusions: High silver concentrations in placental tissue are associated with an elevated risk for NTDs in offspring. Maternal diet may be a source of silver exposure.

show abstract

“…During pregnancy, essential elements such as chromium (Cr), manganese (Mn), cobalt (Co), copper (Cu), zinc (Zn), and selenium (Se) are essential for various physiological processes [ 21 ]. For example, matrix metalloproteinases (MMPs) are a family of zinc- and calcium-dependent endopeptidases involved in cytotrophoblast migration and invasion of the uterine wall and in the remodeling of the spiral arteries [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Reduction in Placental Metal and Metalloid in Preeclampsia: A Case–Control Study

Hao,

Yu,

et al. 2024

Nutrients

View full text Add to dashboard Cite

Preeclampsia is a primary placental disorder, with impaired placental vascularization leading to uteroplacental hypoperfusion. We aimed to investigate differences in metal and metalloid content between the placentas of women with preeclampsia and healthy controls. This was a case–control study in 63 women with preeclampsia and 113 healthy women. Clinical data were obtained from medical records. Inductively coupled plasma mass spectrometry (ICP-MS) was used to measure the placental metals and metalloids content. Compared with healthy control subjects, preeclampsia was associated with a significantly lower concentration of essential elements (magnesium, calcium, iron, copper, zinc, and selenium) in the placental tissue. After multivariable adjustment, an interquartile range (IQR) increase in selenium concentration was associated with a reduced risk of preeclampsia with an OR of 0.50 (95% CI: 0.33–0.77). The joint effects of multiple selected metals and metalloids were associated with a reduced risk of preeclampsia. The lower placental magnesium, chromium, iron, zinc, and selenium concentrations of preeclampsia cases indicate a potential link to its pathogenesis. It also provides an intriguing avenue for future research in revealing the underlying mechanisms and potential intervention strategies for preeclampsia.

show abstract

Higher concentration of selenium in placental tissues is associated with reduced risk for orofacial clefts

Cited by 12 publications

References 40 publications

Maternal Zinc, Copper, and Selenium Intakes during Pregnancy and Congenital Heart Defects

Maternal Zinc, Copper, and Selenium Intakes during Pregnancy and Congenital Heart Defects

Prenatal exposure to silver is associated with an elevated risk for neural tube defects: a case–control study

Reduction in Placental Metal and Metalloid in Preeclampsia: A Case–Control Study

Contact Info

Product

Resources

About