Wheat is one of the main crops worldwide with a production of 733 million of tons by 2015. By 2013, the wheat grain production in Mexico was 3,357,307 t. Wheat straw is generated as a biomass waste once the wheat is harvested. However, the agricultural biomass waste has acquired international relevance as a source of bioenergy. The utilization of bioenergy has signiicant environmental beneits, and also economic beneits because the biomass waste is valorized as biofuel. The use of wheat straw as raw material for any productive process presents diverse factors that must be considered. Among those factors are the low density of biomass, handling and high transportation cost, an atractive heating value, and the physicochemical characterization. Therefore, the aim of this work was to apply the SWOT analysis to wheat straw utilization as a biofuel in Mexico. The main indings highlighted an estimation of 4,612,950.23 t of wheat straw generated. The experimental results of proximate analysis were 64.42% volatile mater, 19.49% ixed carbon and 16.09% ash. The higher heating was 14.86 MJ/kg. An energy potential of 69 PJ per agricultural cycle was calculated, equivalent to 19% of the biomass energy share reported in Mexico's National Energy Balance, by 2014.