Higher hemoglobin levels are associated with better physical performance among older adults without anemia: a longitudinal analysis

Corona, Ligiana Pires; Andrade, Flávia Cristina Drumond; Alexandre, Tiago da Silva; Brito, Tábatta Renata Pereira de; Nunes, Daniella Pires; Duarte, Yeda Aparecida de Oliveira

doi:10.1186/s12877-022-02937-4

Cited by 10 publications

(5 citation statements)

References 41 publications

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“…The gender comparison-by using all three cut-off levels-in non-anemic subjects showed that men had a better cognitiveaffective, functional, and nutritional status than women. As expected [45,46], from our data, it emerged that anemic patients showed a more advanced age, a greater deflection of mood, less functional capacities, malnutrition, and more severe comorbidities. On the contrary, however, we did not observe a greater cognitive impairment in anemic patients, in agreement to some evidence [47].…”

Section: Discussionsupporting

confidence: 83%

“…The causes of anemia in the elderly are various and often more than one contributes to its genesis. Anemia has been associated with increased comorbidity (including neurological and psychiatric disorders), worsening physical performance, quality of life, and increased frequency and duration of hospital admissions [45][46][47][48][49][50]. Despite its clinical importance, anemia in the elderly is poorly recognized and the evidence-based guidelines for its management are lacking.…”

Section: Discussionmentioning

confidence: 99%

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Anemia in Elderly Patients—The Impact of Hemoglobin Cut-Off Levels on Geriatric Domains

et al. 2023

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Background: The primary aim of this study was to evaluate the impact of anemia—according to the WHO criteria—on cognitive performances, mood, functional and nutritional status, and comorbidities in a population of subjects aged 65 years or older. The secondary aim of this study was to understand if different hemoglobin cut-off levels are associated with a variation of the mentioned domains’ impairment. Methods: We designed a cross-sectional study, including subjects aged 65 or more consecutively evaluated in an outpatient setting from July 2013 to December 2019. A sum of 1698 subjects met the inclusion criteria. They were evaluated with: MMSE and CDT (cognitive assessment), GDS (mood), BADL, IADL, PPT, and POMA (autonomies), MNA (nutritional status), and CIRS (comorbidities). Results: According to the WHO criteria, non-anemic patients reported significantly better performances than the anemics in BADL (p < 0.0001), IADL (p = 0.0007), PPT (p = 0.0278), POMA (p = 0.0235), MNA, CIRS TOT, CIRS ICC, and CIRS ISC (p < 0.0001). The same tendency has been found by considering the 12 g/dL- and the 13 g/dL-cut-off level in the whole population. The multivariate analysis showed that, considering the 12 g/dL-cut-off level, age (OR: 1.03, p = 0.0072), CIRS (OR: 1.08, p < 0.0001), and gender (OR: 0.57, p = 0.0007) were significant regressors of anemia, while considering the 13 g/dL-cut-off level, age (OR: 1.04, p = 0.0001), POMA (OR: 1.03, p = 0.0172), MNA (OR = 0.95, p = 0.0036), CIRS (OR: 1.17, p < 0.0001), ICC (OR = 0.83, p = 0.018), and gender (OR = 0.48, p < 0.0001) were significant regressors of anemia, while the other CGA variables were excluded by the model (p > 0.01). Conclusions: Our study showed that anemia negatively impact on geriatric people’s general status, regardless of which hemoglobin cut-off level is considered. It also highlighted that hemoglobin concentrations < 13 g/dL, regardless of gender, have an association with the impairment of the affective-functional-nutritional state as well as an increase in comorbidities; therefore, it should be pursuable to consider the elderly person “anemic” if Hb < 13 g/dL regardless of gender.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Anemia in Elderly Patients—The Impact of Hemoglobin Cut-Off Levels on Geriatric Domains

et al. 2023

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“…Anemia decreases a patient's oxygen-carrying capacity, weakens muscle strength, and decreases body activity and physical state (34). The findings of the present study indicated that at the end of 3 months of treatment, hemoglobin in HCF group was significantly higher than that of the control group.…”

Section: Discussionmentioning

confidence: 43%

Effect of the hospital-community-family (HCF) nutritional management on patients with esophageal and head and neck cancers undergoing radiotherapy: a randomized control trial

Zhou¹,

Luo²,

Pang³

et al. 2023

Transl Cancer Res

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Background: Malnutrition is particularly common in patients undergoing radiotherapy for head and neck cancers (HNC) and esophageal cancers (EC). Proper nutritional management plays an important role in improving the nutritional status and reducing complications in patients undergoing radiotherapy for malignancy. With most nutrition studies limited to the nutritional management of patients during hospitalization or after discharge, there is a lack of research evidence on the nutritional management of patients in combination with out-of-hospital. The aim of this study was to evaluate the effect of the hospital-community-family (HCF) nutritional management model on nutritional status and radiotherapy complications in EC and HNC radiotherapy patients.Methods: Between October 2019 and October 2021, a total of 116 EC and HNC radiotherapy patients were randomized into control group (conventional nutritional support) and experimental group (HCFmodel nutritional management), and assessed weekly for 3 months. The primary endpoint was the patient's Nutrition Risk Screening 2002 (NRS2002) score, Scored Patient-Generated Subjective Global Assessment (PG-SGA), weight change, and Eastern Cooperative Oncology Group (ECOG) score from baseline level to 3 months after the end of treatment. The secondary endpoints were the incidence of albumin, hemoglobin, hematological parameters, and radiotherapy complications.Results: A total of 95 patients (47 in the control group and 48 in the experimental group) completed the study. At 3 months after treatment, NRS2002 (P=0.028) and PG-SGA (P=0.022) decreased, and albumin was higher (P=0.001) than at the beginning of treatment in HCF group. Weight decreased (P<0.001) and PG-SGA was higher after 3 months of treatment (P=0.012) in the control group. PG-SGA (P<0.001), NRS2002 (P<0.001), and ECOG (P=0.006) in the HCF group at the end of the 3-month treatment period were lower in the conventional group (P<0.05). The incidence of radiation mucositis (P=0.018)and radiation dermatitis (P=0.028) in the HCF nutrition management group was significantly reduced (P<0.05).Conclusions: HCF-model nutritional management significantly improved the nutritional status and reduced the incidence and severity of radiation mucositis and dermatitis for EC and HNC radiotherapy patients. These findings suggest that HCF-model nutritional management is a promising nutritional management model.

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“…Hemoglobin level not only reflected the nutritional status but also was an indicator for the complications and outcomes 13 – 15 . A longitudinal analysis in old adults without anemia showed that higher hemoglobin levels were linked with better physical performance 16 . One observational study found that in patients with hip fracture, preoperative hemoglobin levels ≥ 10 g/dl lead to a 50% decreased risk of mortality compared to patients with hemoglobin levels < 10 g/dl (hazard ration(HR) = 0.50, 95% CI 0.25–0.99, P = 0.048) 17 .…”

Section: Discussionmentioning

confidence: 99%

Association between admission hemoglobin level and prognosis in sepsis patients based on a critical care database

Peng,

Su,

Luo

et al. 2024

Sci Rep

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This study aimed to explore the association between admission hemoglobin level and clinical outcomes in sepsis based on Medical Information Mart for Intensive Care IV(MIMIC-IV) database. It was a retrospective study. Sepsis patients in the database were included. Data extraction from MIMIC-IV was performed by PostgreSQL 9.6 software. Three different models including crude model (adjusted for none), model I (adjusted for gender and age) and model II (adjusted for all potential cofounders) were constructed. A generalized liner model and a smooth fitting curve for indicating the relationship between hemoglobin level and 30-day mortality were performed. 6249 septic patients with a 30.18% of 30-day mortality were included. With 1 g/dl increment in hemoglobin level, the values of odds ratio (OR) in crude model, model I and model II were 0.96 (95% confidential interval (CI) 0.94–0.99, P = 0.0023), 0.96 (95%CI 0.93–0.98, P = 0.0010) and 0.87 (95%CI 0.79–0.95, P = 0.0020), respectively. The smooth fitting curve indicated a non-linear relationship and the turning point was 7.2 g/dl. Compared the hemoglobin group < 7.2 g/dl, the risk of 30-day mortality significantly decreased by 32% in the hemoglobin group ≥ 7.2 g/dl (OR = 0.68, 95%CI 0.51–0.93, P = 0.0142). The non-linear relationship between admission hemoglobin level and 30-day mortality in sepsis was found. Hemoglobin supplementation might be beneficial for septic patients with hemoglobin level < 7.2 g/dl.

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Higher hemoglobin levels are associated with better physical performance among older adults without anemia: a longitudinal analysis

Cited by 10 publications

References 41 publications

Anemia in Elderly Patients—The Impact of Hemoglobin Cut-Off Levels on Geriatric Domains

Anemia in Elderly Patients—The Impact of Hemoglobin Cut-Off Levels on Geriatric Domains

Effect of the hospital-community-family (HCF) nutritional management on patients with esophageal and head and neck cancers undergoing radiotherapy: a randomized control trial

Association between admission hemoglobin level and prognosis in sepsis patients based on a critical care database

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