Higher incidence of nasopharyngeal carcinoma in some regions in the world confers for interplay between genetic factors and external stimuli

Chattopadhyay, Nabanita Roy; Das, Piyanki; Chatterjee, Koustav; Choudhuri, Tathagata

doi:10.5582/ddt.2017.01030

Cited by 32 publications

(19 citation statements)

References 75 publications

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“…NPC is a malignant tumor derived from nasopharyngeal epithelial cells. It is widely accepted that NPC is a complicated disease associated with multiple factors including genetics (27,28), Epstein-Barr virus infection (29)(30)(31) and the environment (32). Thus far, researchers have mainly focused on improving our understanding of NPC pathogenesis (33)(34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma

Huang

Liu

et al. 2018

Oncol Rep

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SETDB1, an H3K9‑specific histone methyltransferase, has been described as a repressed transcription marker which triggers tumorigenesis of many types of human cancer. However, there are few studies elucidating the relationship between SETDB1 and nasopharyngeal carcinoma. In the present study, we confirmed that SETDB1 exhibited higher expression levels in nasopharyngeal carcinoma (NPC) tissues and cell lines, compared to these levels in non‑tumor tissues and a normal human nasopharyngeal epithelial cell line. Kaplan‑Meier analysis showed that higher SETDB1 expression indicated an unfavorable prognosis for NPC patients, making it an independent prognostic factor for NPC in the COX proportional hazards model. In vitro functional studies revealed that upregulation of SETDB1 expression in CNE1 cells promoted cell proliferation, possibly through cell cycle G1/S phase transition. Moreover, it also enhanced cell migration and invasion ability. Downregulation of SETDB1 expression in 5‑8F cells resulted in the opposite response. Overall, the findings indicated that increased expression of SETDB1 may predict poor overall survival and the malignant phenotype of NPC.

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Section: Discussionmentioning

confidence: 99%

Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma

Huang

Liu

et al. 2018

Oncol Rep

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“…Our Meta-analysis revealed significant association of salted fish to NPC risk with random effect model score showing OR of 1.41 at 95% confidence interval (CI) of 1.13-1.75 (P<0.01). Previous studies have demonstrated that the processes of preserving fish with salt triggers high nitrosamines accumulation which is carcinogenic (Chattopadhyay et al, 2017;Yong et al, 2017). Several foods such as salted fish and various preserved foods containing nitrosamines increase the incidence rate of NPC (Lo et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…However, results across various studies have not been entirely consistent. The high incidence of NPC found among the Chinese population in China that migrated to other regions of the world suggests that the dietary habit of this population contributes to NPC development (Chattopadhyay et al, 2017). Due to economic growth and development over the last decade, lifestyle and dietary habits have changed.…”

Section: Introductionmentioning

confidence: 99%

Nasopharyngeal Carcinoma (NPC) Risk Factors: A Systematic Review and Meta-Analysis of the Association with Lifestyle, Diets, Socioeconomic and Sociodemographic in Asian Region

Okekpa

Mydin

Mangantig

et al. 2019

Asian Pac J Cancer Prev

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Objective: Risk factors of nasopharyngeal carcinoma (NPC) have been linked with diets, life style and viral infections. NPC is more rampant in Asian populations than non-Asian countries. Our study aims to assess the validity of the suggestions provided by multiple case control studies demonstrating that salted fish consumption, smoking and alcohol consumption are associated with the risk of NPC in Asia. Methods: Search for related literature on salted fish, smoking and alcohol consumption were performed via Science Direct, PubMed databases and Google Scholar. Articles included in this study were from 2009 to 2017, with specific focus on salted fish, smoking and alcohol consumption as risk factors of NPC. This study excluded all articles published prior to 2009 and articles involving other cancers. Data were extracted independently by two different researchers and harmonized. Meta-analysis was conducted on the obtained data, by using R package Meta to create funnel and forest plots. Results: The meta-analysis revealed that salted fish, smoking and alcohol consumption were significantly associated to NPC risk with random effect model score showing

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“…2 The risk factors of NPC consist of three main reasons: viral infection, genetic factors as well as environmental and dietary factors. 3 Except for active anticancer agents and intensity-modulated radiation therapy, cancer stem cells together with gene therapy are considered as novel concepts and promising regimens for the treatment of NPC, while these technologies have yet been put into clinical use. 4 In view of the lack of reliable data, the pathogenesis and clinical use of NPC biomarkers remain to be uncovered.…”

Section: Introductionmentioning

confidence: 99%

LncRNA ZNF667-AS1 Promotes ABLIM1 Expression by Adsorbing microRNA-1290 to Suppress Nasopharyngeal Carcinoma Cell Progression

Chen

Huang

Shi

et al. 2020

OTT

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Background: Recently, long non-coding RNAs (lncRNAs) have been elucidated to play essential roles in cancers, and the recognition of lncRNA expression patterns in nasopharyngeal carcinoma (NPC) may be helpful for indicating novel mechanisms underlying NPC carcinogenesis. Herein, we conducted this study to probe into the function of lncRNA ZNF667-AS1 in NPC progression with the involvement of microRNA-1290 (miR-1290) and actin-binding LIM protein 1 (ABLIM1). Materials and Methods: In silico analysis screened differentially expressed genes and miRNAs in NPC and predicted potential mechanisms. ZNF667-AS1 expression was detected in NPC tissues and cells. The gain-and-loss function assays were performed to explore the effects of lncRNA ZNF667-AS1 and miR-1290 in NPC cell biological behaviors. In vivo experiments were further conducted to confirm the in vitro results. Results: In silico analysis predicted that ZNF667-AS1 was diminished in NPC, which may downregulate ABLIM1 through sponging miR-1290. ZNF667-AS1 was poorly expressed in NPC tissues and cells, and overexpression of ZNF667-AS1 inhibited growth of NPC cells. ZNF667-AS1 competitively bound with miR-1290, thereby upregulating ABLIM1. miR-1290 resulted in the promotion of NPC cell progression by suppressing ABLIM1. Overexpression of ZNF667-AS1 or suppression of miR-1290 inhibited tumorigenicity of NPC cells in vivo. Conclusion: This study highlights that lncRNA ZNF667-AS1 promotes ABLIM1 expression by sponging miR-1290 to suppress NPC cell progression.

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Higher incidence of nasopharyngeal carcinoma in some regions in the world confers for interplay between genetic factors and external stimuli

Cited by 32 publications

References 75 publications

Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma

Enhanced expression of SETDB1 possesses prognostic value and promotes cell proliferation, migration and invasion in nasopharyngeal carcinoma

Nasopharyngeal Carcinoma (NPC) Risk Factors: A Systematic Review and Meta-Analysis of the Association with Lifestyle, Diets, Socioeconomic and Sociodemographic in Asian Region

<p>LncRNA <em>ZNF667-AS1</em> Promotes <em>ABLIM1</em> Expression by Adsorbing <em>microRNA-1290</em> to Suppress Nasopharyngeal Carcinoma Cell Progression</p>

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