Higher maternal leptin levels at second trimester are associated with subsequent greater gestational weight gain in late pregnancy

Lacroix, Marilyn; Battista, Marie-Claude; Doyon, Myriam; Moreau, Julie; Patenaude, Johane; Guillemette, Laetitia; Ménard, Julie; Ardilouze, Jean-Luc; Perron, Patrice; Hivert, Marie‐France

doi:10.1186/s12884-016-0842-y

Cited by 48 publications

(59 citation statements)

References 35 publications

(37 reference statements)

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“…On the other hand, in sheep models, insulin has been demonstrated to be responsible for the regulation of the mRNA leptin concentration [23]. In a previous Gen3G report, we observed that higher 2nd-trimester maternal leptin was associated with greater subsequent GWG in late pregnancy, and this was stronger in overweight women [8], seemingly reflecting a positive feedback loop on maternal energy balance. This may suggest an additional potential mechanism where higher maternal leptin could stimulate a greater energy transfer across the placenta, leading to greater fetal adiposity, especially in overweight women.…”

Section: Discussionmentioning

confidence: 82%

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Associations of Maternal Leptin with Neonatal Adiposity Differ according to Pregravid Weight

Patenaude

Lacerte²,

Lacroix³

et al. 2017

Neonatology

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Background: During pregnancy, maternal circulating leptin is released by maternal adipose tissue and the placenta, and may have a role infetal development. Objectives: We investigated maternal leptinemia and glycemia associations with neonatal adiposity, taking into account pregravid weight status. Methods: We included 235 pregnant women from the Genetics of Glucose Regulation in Gestation and Growth prospective cohort with data: blood samples collected during the 2nd trimester, an oral glucose tolerance test (OGTT), and the measured leptin and glucose levels. As an integrated measure of maternal leptin exposure, we calculated the area under the curve for maternal leptin at the OGTT (AUC_leptin). Within 72 h of delivery, we measured the triceps, biceps, subscapular, and suprailiac skinfold thicknesses (SFTs); the sum of these SFTs represented neonatal adiposity. We conducted a regression analysis to assess the maternal metabolic determinants of neonatal adiposity, adjusting for parity, smoking status, maternal triglyceride levels, gestational weight gain, placental weight, delivery mode, neonate sex, and gestational age at delivery. Results: The pregravid BMI of the participating women was 23.3 (21.2-27.0). In the 2nd trimester, maternal AUC_leptin was 1,292.0 (767.0-2,222.5) (ng × min)/mL, and fasting glucose levels were 4.2 ± 0.4 mmol/L. At delivery, the neonatal sum of 4 SFTs was 17.9 ± 3.3 mm. Higher maternal leptinemia was associated with higher neonatal adiposity (β = 4.23 mm [SE = 1.77] per log-AUC_leptin; p = 0.02) in mothers with a BMI ≥25, independently of confounders and maternal glycemia, but not in mothers with a BMI <25. Higher maternal fasting glucose was associated with higher neonatal adiposity (β = 0.88 mm [SE = 0.30] per SD glucose; p = 0.005) in mothers with a BMI <25, independently of confounders and maternal leptinemia. Conclusion: Maternal leptinemia may be associated with neonatal adiposity in offspring from overweight/obese mothers, independently of maternal glycemia.

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Section: Discussionmentioning

confidence: 82%

“…About 80% of placental leptin is secreted towards maternal circulation. We previously found that higher 2nd-trimester maternal leptin levels were associated with greater subsequent GWG in late pregnancy [8]. Very little is known about the role of maternal leptin on fetal growth and neonatal adipose tissue accretion.…”

Section: Introductionmentioning

confidence: 99%

Associations of Maternal Leptin with Neonatal Adiposity Differ according to Pregravid Weight

Patenaude

Lacerte²,

Lacroix³

et al. 2017

Neonatology

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“…Встановлену нами відсутність зв'язку зростання лептину в першому триместрі з подальшим ГЗМТ приводять в своїх роботах Walsh et al [13]. На виявлену нами позитивну асоціацію між гіперлептинемією та ГЗМТ і відсотком ЖМТ в другому та третьому триместрах вказують і поодинокі інші дослідження [14], проте вони не враховують рівень гестаційного приросту.…”

Section: проблеми ендокринної патології № 3 2019unclassified

Association of Hypertleptinemia and Gestational Weight Gain

Ostafiichuk

Henyk

2019

PEP

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Роботу виконано в рамках науково-дослідної роботи «Клініко-патогенетичні шляхи зниження частоти порушень репродуктивного здоров'я та перинатальних ускладнень жінок Прикарпаття» (державний реєстраційний № 0114U004747). Установою, що фінансує дослідження, є МОЗ України. Автори гарантують повну відповідальність за все, що опубліковано в статті. Автори гарантують відсутність конфлікту інтересів і власної фінансової зацікавленості при виконанні роботи та написанні статті. Рукопис надійшов до редакції 22.02.2019.

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“…Ha arra gondolunk, hogy ebben az időszakban a terhes anyák jelentős súlytöbbletet halmoznak fel, akkor valóban kérdéses ezt katabolikus fázisnak tekinteni. 20,21 (2. ábra).…”

Section: Laboratóriumi éRtékek éS Ami Mögöttük Vanunclassified

Glukóz- és zsíranyagcsere terhességben

Rácz¹,

Brenišin²,

Maceková³

2017

Diabetologia Hungarica

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A szerzők ismertetik a glukóz-és a zsíranyagcsere változásait anyagcserezavarral nem társuló terhességben, valamint gestatiós diabetesben és preeclampsiában. Rámutatnak arra, hogy a terhesség alatti laboratóriumi referenciaadatok hiányosak és nem egyeznek a kóros állapotok diagnózisában alkalmazott határértékekkel sem. A glukóz-és a lipidanyagcsere terhesség alatti változásainak középpontjában az inzulinrezisztencia áll, amely ebben az esetben nem kóros folyamat, hanem a fokozatosan növekvő magzati igényekre bekövetkező kompenzációs válasz. Külön fejezetben tárgyalják az adipokinek szerepét a terhességi anyagcsere-folyamatokban. Feltételezik, hogy a gestatiós diabetes patogenezisét tekintve nem egységes kórkép, és rámutatnak arra is, hogy a preeclampsia patogenezisében is fontos szerepet játszik az inzulinrezisztencia. Az irodalmi áttekintést javaslatok zárják a megválaszolatlan kérdések lehetséges megoldásaira. ■ Kulcsszavak: terhesség, anyagcsere, inzulinrezisztencia, gestatiós diabetes, preeclampsia Glucose-and lipid metabolism during pregnancy Summary: Modifications of glucose and lipid metabolism during pregnancy not accompanied by metabolic disturbances, as well as in gestational diabetes and preclampsy are discussed in the review article. Deficient laboratory reference values in normal pregnancy and alterations from those observed in different pathologic conditions are emphasized by the authors. The insulin resistance which is the key element of metabolic regulation during pregnancy is not a pathological process but a physiological adaptation, a compensatory response of the maternal organism to increasing fetal metabolic needs. The role of different adipokines in normal pregnancy as well as in gestational diabetes is also discussed in detail. From pathogenetic point of view the gestational diabetes is not a unified disease. Possibilities for future investigations to clarify the still open questions and suggestions of the authors are also summarised.

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Higher maternal leptin levels at second trimester are associated with subsequent greater gestational weight gain in late pregnancy

Cited by 48 publications

References 35 publications

Associations of Maternal Leptin with Neonatal Adiposity Differ according to Pregravid Weight

Associations of Maternal Leptin with Neonatal Adiposity Differ according to Pregravid Weight

Association of Hypertleptinemia and Gestational Weight Gain

Glukóz- és zsíranyagcsere terhességben

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