Higher maternal plasma docosahexaenoic acid during pregnancy is associated with more mature neonatal sleep-state patterning

Cheruku, Sunita R; Montgomery‐Downs, Hawley E.; Farkas, Susanna L; Thoman, Evelyn B.; Lammi‐Keefe, Carol J.

doi:10.1093/ajcn/76.3.608

Cited by 129 publications

(66 citation statements)

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“…A relation between DHA status and sleep disturbances was also reported by Cheruku et al who studied sleep patterns in newborn babies delivered from 17 women as a function of plasma phospholipid DHA levels. 16 They found that babies born to mothers with DHA levels above the median (above 3% of total phospholipid FAs) had more mature sleep wake cycles than those born to mothers with lower DHA levels. The authors indicated that more mature sleep patterns suggested more mature central nervous system development.…”

Section: Discussionmentioning

confidence: 97%

“…15 Exposure to lower omega-3 levels in utero is associated with less mature sleep patterns in newborn babies. 16 This nexus suggests a possible biochemical link between omega-3 FA defi ciency and OSA. The purpose of this study was to determine the extent to which OSA was associated with reduced omega-3 FA levels measured in a surrogate for tissue omega-3 levels, the RBC membrane.…”

mentioning

confidence: 99%

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Membrane Level of Omega-3 Docosahexaenoic Acid Is Associated with Severity of Obstructive Sleep Apnea

Ladesich

Pottala

Romaker³

et al. 2011

Journal of Clinical Sleep Medicine

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background: Patients with obstructive sleep apnea (OSA) are at increased risk of cardiovascular disease (CVD). The omega-3 fatty acid docosahexaenoic acid (DHA) is a major component of neural tissues, and supplementation with fi sh oils improves autonomic tone and reduces risk for CVD. A link between low DHA status and less mature sleep patterns was observed in newborns. Methods: We investigated the relations between red blood cell (RBC) levels of DHA and OSA severity in 350 sequential patients undergoing sleep studies. Severity categories were defi ned as none/mild, moderate, and severe, based on apnea hypopnea index (AHI) scores of 0 to 14, 15 to 34, and > 34, respectively. Results: After controlling for age, sex, race, smoking, BMI, alcohol intake, fi sh intake, and omega-3 supplementation, RBC DHA was inversely related with OSA severity. For each 1-SD increase in DHA levels, a patient was about 50% less likely to be classifi ed with severe OSA. The odds ratios (95% CI) were 0.47 (0.28 to 0.80) and 0.55 (0.31 to 0.99) for being in the severe group versus the none/mild or moderate groups, respectively. Conclusion: These fi ndings suggest that disordered membrane fatty acid patterns may play a causal role in OSA and that the assessment of RBC DHA levels might help in the diagnosis of OSA. The effects of DHA supplementation on OSA should be explored. keywords: Omega-3 fatty acids, docosahexaenoic acid, epidemiology, sleep disordered breathing, biomarkers Citation: Ladesich JB; Pottala JV; Romaker A; Harris WS. Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Membrane Level of Omega-3 Docosahexaenoic Acid Is Associated with Severity of Obstructive Sleep Apnea

Ladesich

Pottala

Romaker³

et al. 2011

Journal of Clinical Sleep Medicine

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“…A habitual high maternal fish intake would also affect the DHA supply during fetal development. Several studies have shown that DHA status during pregnancy or at delivery can affect infant cognitive development [20,21]. The results of the Norwegian maternal FO-supplementation trial in which cod liver oil was provided from the 18th week of gestation indicate that the intrauterine DHA exposure is more important for mental development than that in post-natal life [26].…”

Section: Discussionmentioning

confidence: 99%

“…At present there is insufficient scientific evidence to determine whether the variation in DHA level in breast-milk has functional implications for the breast-fed infant. Small cross sectional studies have observed relationship between the DHA-content of human milk, or levels of DHA in infant or maternal plasma, and the sleep pattern, visual acuity, cognitive abilities, speech perception and language development of breast-fed infants [14,15,[20][21][22][23][24]. Furthermore, studies supplementing lactating mothers with marine oils have shown that the DHA-intake of breast-fed infants may have beneficial effects on mental development [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants

Lauritzen¹,

et al. 2005

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-Docosahexaenoic acid (DHA) accumulates in the brain during the 1st and 2nd years of life. The objective of this study was to see if an increased content of DHA in breast-milk via maternal fish oil (FO)-supplementation affects mental development in term infants. one hundred twenty-two Danish mothers with a habitual fish intake below the population median were randomized to 4.5 g·d -1 of FO or olive oil (OO) for the first four months of lactation. Fifty-three mothers with habitual fish intake in the highest quartile were included as reference group. The effect of the resulting increase in infant DHA-intake and RBC-DHA level was assessed on problem solving ability at nine months and language at one and two years of age. Infants in the three groups performed equally well on the problem test and no association was observed between problem solving and erythrocyte-DHA at four months. Passive vocabulary at one year was lower in the children of the FO-compared with the OOgroup (P < 0.05), but no differences were found at two years of age. Word comprehension at one year was inversely associated with erythrocyte-DHA at four months. The trial indicate a small effect of DHA levels in breast-milk on early language development of breast-fed infants.docosahexaenoic acid / breast-milk / infant development / long-chain n-3 fatty acid / optimal dietary intake Abbreviations: AA: arachidonic acid; CDI: communicative development inventory; DHA: docosahexaenoic acid; FO: fish oil; LCPUFA: long-chain polyunsaturated fatty acid; OO: olive oil; PUFA: polyunsaturated fatty acid; RBC: red blood cells.

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“…В другом когортном исследовании показано, что высокое содержание ДГК в сыворотке крови у женщин во время беременности сопровождалось такими благо-приятными эффектами у рождаемых детей, как более упо-рядоченный показатель структуры сна в раннем детстве [46], более успешная концентрация внимания в первые 2 года жизни [47], более высокая степень моторного раз-вития и меньшее число поведенческих проблем в воз-расте 7 лет [48]. Группой сравнения в этом исследовании служили дети, матери которых во время беременности дополнительно не получали ДГК.…”

Section: обзор литературыunclassified

Long-Chain Polyunsaturated Fatty Acids and Their Role in Children Nourishment

Боровик¹,

Грибакин²,

Скворцова³

et al. 2012

Vopr. sovr. pediatr.

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Несомненным достижением нутрициологии в пос-ледней четверти ХХ в. являются результаты детального изучения роли длинноцепочечных полиненасыщенных жирных кислот (ДЦПНЖК) в питании человека и в осо-бенности их значение в метаболизме и развитии мозга у детей первого года жизни [1,2]. Отправной точкой при проведении исследований в этом направлении послужили данные об их содержании в грудном молоке [3][4][5]. Было установлено, что грудное молоко содержит относительно низкие концентрации короткоцепочечных жирных кислот и в то же время -значительные количе-ства ДЦПНЖК, в частности арахидоновой (АК) и докоза-гексаеновой (ДГК) [6,7].Показано, что содержание АК в грудном молоке составляет 0,3-0,6%, и ее концентрация относительно стабильна в различных регионах мира, причем не имеет тесной связи с питанием матери. Напротив, содержа-ние ДГК варьирует в достаточно широком диапазоне (от 0,1 до 1,0%) и хорошо коррелирует с содержанием этой кислоты в рационе кормящей женщины [8,9].Важно отметить, что содержание ДЦПНЖК в грудном молоке матерей, родивших недоношенных детей, выше, чем в таковом у женщин после срочных родов [10]. Установлено положительное влияние дополнительного введения АК и ДГК в состав детских молочных смесей на когнитивное развитие и остроту зрения у недоношен-ных детей, а также, хотя и в меньшей степени, у детей, родившихся в срок [11].Известно, что для детей первого года жизни харак-терны быстрый рост и развитие. Поэтому их рацион дол-жен включать в оптимальных количествах и сбаланси-рованных соотношениях основные пищевые вещества,

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Higher maternal plasma docosahexaenoic acid during pregnancy is associated with more mature neonatal sleep-state patterning

Abstract: The sleep patterns of infants born to mothers with higher plasma phospholipid DHA suggest greater CNS maturity.

Cited by 129 publications

References 34 publications

Membrane Level of Omega-3 Docosahexaenoic Acid Is Associated with Severity of Obstructive Sleep Apnea

Membrane Level of Omega-3 Docosahexaenoic Acid Is Associated with Severity of Obstructive Sleep Apnea

Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants

Long-Chain Polyunsaturated Fatty Acids and Their Role in Children Nourishment

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