Higher Maternal Plasma n–3 PUFA and Lower n–6 PUFA Concentrations in Pregnancy Are Associated with Lower Childhood Systolic Blood Pressure

Vidakovic, Aleksandra Jelena; Gishti, Olta; Graaff, Jolien Steenweg–de; Williams, Michelle A.; Duijts, Liesbeth; Felix, Janine F.; Hofman, Albert; Tiemeier, Henning; Jaddoe, Vincent W. V.; Gaillard, Romy

doi:10.3945/jn.115.210823

Cited by 16 publications

(20 citation statements)

References 42 publications

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“… 13 Some of us began measuring childhood BP in 2010 as part of monitoring the overall health of children born to women in the KUDOS trial and because a report of early postnatal DHA supplementation 5 linked lower BP at age 6 years to higher DHA exposure. Subsequent reports from the Netherlands 3 , 4 associating prenatal DHA exposure with lower childhood BP supported our hypothesis that children of women randomized to DHA supplementation would have lower BP.…”

Section: Discussionsupporting

confidence: 68%

Effect of Prenatal Docosahexaenoic Acid Supplementation on Blood Pressure in Children With Overweight Condition or Obesity

et al. 2019

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Key Points Question Is maternal intake of prenatal docosahexaenoic acid associated with reductions in childhood blood pressure? Findings In this prespecified secondary analysis of a randomized clinical trial and follow-up of 171 mothers and their offspring, the children of women randomized to receive prenatal docosahexaenoic acid did not experience an increase in systolic blood pressure and diastolic blood pressure if they became overweight or obese compared with children of women randomized to placebo. A statistically significant interaction was found between prenatal treatment and child weight status. Meaning Docosahexaenoic acid intake during pregnancy may protect children from the blood pressure–elevating consequence of childhood overweight condition or obesity.

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Section: Discussionsupporting

confidence: 68%

Effect of Prenatal Docosahexaenoic Acid Supplementation on Blood Pressure in Children With Overweight Condition or Obesity

et al. 2019

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“…However, no correlations between maternal dietary factors and childhood blood pressure were found to be statistically significant (412). On the other hand, another study found that higher total maternal n-3 PUFA levels were associated with lower childhood systolic blood pressure (419). These studies illustrate the potential for maternal serum markers, whether placental, hormonal, or dietary, to be predictive of adult later-life hypertension in their children, an area which warrants further investigation.…”

Section: Prediction Of Developmental Programmingmentioning

confidence: 88%

In Utero Origins of Hypertension: Mechanisms and Targets for Therapy

Morton

Cooke

Davidge³

2016

Physiological Reviews

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The developmental origins of health and disease theory is based on evidence that a suboptimal environment during fetal and neonatal development can significantly impact the evolution of adult-onset disease. Abundant evidence exists that a compromised prenatal (and early postnatal) environment leads to an increased risk of hypertension later in life. Hypertension is a silent, chronic, and progressive disease defined by elevated blood pressure (>140/90 mmHg) and is strongly correlated with cardiovascular morbidity/mortality. The pathophysiological mechanisms, however, are complex and poorly understood, and hypertension continues to be one of the most resilient health problems in modern society. Research into the programming of hypertension has proposed pharmacological treatment strategies to reverse and/or prevent disease. In addition, modifications to the lifestyle of pregnant women might impart far-reaching benefits to the health of their children. As more information is discovered, more successful management of hypertension can be expected to follow; however, while pregnancy complications such as fetal growth restriction, preeclampsia, preterm birth, etc., continue to occur, their offspring will be at increased risk for hypertension. This article reviews the current knowledge surrounding the developmental origins of hypertension, with a focus on mechanistic pathways and targets for therapeutic and pharmacologic interventions.

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“…Increased concentrations of free fatty acids during pregnancy are associated with childhood obesity [ 41 , 42 ]. Previously, we have shown that higher maternal n-3 PUFA and lower n-6 PUFA concentrations in pregnancy are also associated with lower childhood systolic blood pressure [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Body mass index, gestational weight gain and fatty acid concentrations during pregnancy: the Generation R Study

et al. 2015

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Obesity during pregnancy may be correlated with an adverse nutritional status affecting pregnancy and offspring outcomes. We examined the associations of prepregnancy body mass index and gestational weight gain with plasma fatty acid concentrations in mid-pregnancy. This study was embedded in a population-based prospective cohort study among 5636 women. We obtained prepregnancy body mass index and maximum weight gain during pregnancy by questionnaires. We measured concentrations of saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), n-3 polyunsaturated fatty acid (n-3 PUFA) and n-6 polyunsaturated fatty acid (n-6 PUFA) at a median gestational age of 20.5 (95 % range 17.1–24.9) weeks. We used multivariate linear regression models. As compared to normal weight women, obese women had higher total SFA concentrations [difference: 0.10 standard deviation (SD) (95 % Confidence Interval (CI) 0, 0.19)] and lower total n-3 PUFA concentrations [difference: − 0.11 SD (95 % CI − 0.20, − 0.02)]. As compared to women with sufficient gestational weight gain, those with excessive gestational weight gain had higher SFA concentrations [difference: 0.16 SD (95 % CI 0.08, 0.25)], MUFA concentrations [difference: 0.16 SD (95 % CI 0.08, 0.24)] and n-6 PUFA concentrations [difference: 0.12 SD (95 % CI 0.04, 0.21)]. These results were not materially affected by adjustment for maternal characteristics. Our results suggest that obesity and excessive weight gain during pregnancy are associated with an adverse fatty acids profile. Further studies are needed to assess causality and direction of the observed associations. Electronic supplementary materialThe online version of this article (doi:10.1007/s10654-015-0106-6) contains supplementary material, which is available to authorized users.

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Higher Maternal Plasma n–3 PUFA and Lower n–6 PUFA Concentrations in Pregnancy Are Associated with Lower Childhood Systolic Blood Pressure

Cited by 16 publications

References 42 publications

Effect of Prenatal Docosahexaenoic Acid Supplementation on Blood Pressure in Children With Overweight Condition or Obesity

Effect of Prenatal Docosahexaenoic Acid Supplementation on Blood Pressure in Children With Overweight Condition or Obesity

In Utero Origins of Hypertension: Mechanisms and Targets for Therapy

Body mass index, gestational weight gain and fatty acid concentrations during pregnancy: the Generation R Study

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