Higher resting-state BNST-CeA connectivity is associated with greater corrugator supercilii reactivity to negatively valenced images

Pedersen, Walker S.; Schaefer, Stacey M.; Gresham, Lauren K.; Lee, Seungbeum D.; Kelly, Michael; Mumford, Jeanette A.; Oler, Jonathan A.; Davidson, Richard J.

doi:10.1016/j.neuroimage.2019.116428

Cited by 16 publications

(14 citation statements)

References 72 publications

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“…Our shared ICN results are in broad agreement with the previous literature, specifically demonstrating overlapping connections within a now widely reported ExtA ICN that includes the mPFC, bilateral hippocampus, insular regions, wider amygdala areas, and the precuneus (Avery et al, 2014;Gorka et al, 2018;Pedersen et al, 2020;Tillman et al, 2018;Torrisi et al, 2015Torrisi et al, , 2019Weis et al, 2019). We report shared iFC to lateral temporal regions, including the superior and middle temporal gyri and the temporal poles, again largely consistent with previous human iFC results.…”

Section: Intrinsic Connectivity Network Of the Extasupporting

confidence: 92%

“…Weis et al reported no robust associations within BST, CeA, or BLA iFC with trait anxiety in a sample of healthy undergraduates (Weis et al, 2019). This was also the case in a study by Pederson et al who, when looking at within ExtA (i.e., BST‐CeA) iFC found no significant associations with trait anxiety or negative affect in a healthy sample (Pedersen et al, 2020).…”

Section: Discussionmentioning

confidence: 56%

“…who, when looking at within ExtA (i.e., BST-CeA) iFC found no significant associations with trait anxiety or negative affect in a healthy sample (Pedersen et al, 2020).…”

Section: Principal Components and Exta Ifcmentioning

confidence: 73%

“…Studies that do report ExtA associations with negative disposition phenotypes are overwhelmingly conducted either in clinical populations or during task‐based fMRI where state anxiety or fear is induced (Andreatta et al, 2015; Brinkmann et al, 2018; Choi, Padmala, & Pessoa, 2012; Grupe, Oathes, & Nitschke, 2013; Klumpers, Kroes, Baas, & Fernández, 2017; Mobbs et al, 2010; Naaz, Knight, & Depue, 2019; Pedersen et al, 2020; Torrisi et al, 2019). There could be a number of reasons for this discrepancy.…”

Section: Discussionmentioning

confidence: 99%

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Extended‐amygdala intrinsic functional connectivity networks: A population study

Berry

Wise

Lawrence

et al. 2020

Human Brain Mapping

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Pre‐clinical and human neuroimaging research implicates the extended‐amygdala (ExtA) (including the bed nucleus of the stria terminalis [BST] and central nucleus of the amygdala [CeA]) in networks mediating negative emotional states associated with stress and substance‐use behaviours. The extent to which individual ExtA structures form a functionally integrated unit is controversial. We utilised a large sample (n > 1,000 healthy young adult humans) to compare the intrinsic functional connectivity networks (ICNs) of the BST and CeA using task‐free functional magnetic resonance imaging (fMRI) data from the Human Connectome Project. We assessed whether inter‐individual differences within these ICNs were related to two principal components representing negative disposition and alcohol use. Building on recent primate evidence, we tested whether within BST‐CeA intrinsic functional connectivity (iFC) was heritable and further examined co‐heritability with our principal components. We demonstrate the BST and CeA to have discrete, but largely overlapping ICNs similar to previous findings. We found no evidence that within BST—CeA iFC was heritable; however, post hoc analyses found significant BST iFC heritability with the broader superficial and centromedial amygdala regions. There were no significant correlations or co‐heritability associations with our principal components either across the ICNs or for specific BST‐Amygdala iFC. Possible differences in phenotype associations across task‐free, task‐based, and clinical fMRI are discussed, along with suggestions for more causal investigative paradigms that make use of the now well‐established ExtA ICNs.

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Section: Intrinsic Connectivity Network Of the Extasupporting

confidence: 92%

Section: Discussionmentioning

confidence: 56%

“…who, when looking at within ExtA (i.e., BST-CeA) iFC found no significant associations with trait anxiety or negative affect in a healthy sample (Pedersen et al, 2020).…”

Section: Principal Components and Exta Ifcmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Extended‐amygdala intrinsic functional connectivity networks: A population study

Berry

Wise

Lawrence

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…One reason that we did not observe an association may be because our sample consists of a screened, relatively healthy population. Evidence for BNST involvement in dispositional negativity or stress-related traits generally comes from studies of clinical populations, or during experiments when states such as fear/anxiety have been induced (Brinkmann et al, 2018;Klumpers et al, 2017;Mobbs et al, 2010;Pedersen et al, 2020). In addition, some researchers have proposed that human self-report emotions should be considered as distinct from the sub-cortical and physiological processes often studied in animal models (LeDoux & Hofmann, 2018).…”

Section: Human Subiculum Complex -Bnst Tract Microstructure Heritability and Potential Functional Attributesmentioning

confidence: 99%

Subiculum – BNST Structural Connectivity in Humans and Macaques

Berry

Lawrence

Lancaster

et al. 2021

Preprint

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Invasive tract-tracing studies in rodents implicate a direct connection between the subiculum and bed nucleus of the stria terminalis (BNST) as a key component of neural pathways mediating hippocampal regulation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. A clear characterisation of the connections linking the subiculum and BNST in humans and non-human primates is lacking. To address this, we first delineated the projections from the subiculum to the BNST using anterograde tracers injected into macaque monkeys, revealing evidence for a monosynaptic subiculum-BNST projection involving the fornix. Second, we used in vivo diffusion MRI tractography in macaques and humans to demonstrate substantial subiculum complex connectivity to the BNST in both species. This connection was primarily mediated through the fornix, with additional connectivity via the amygdala, consistent with rodent anatomy. Third, utilising the twin-based nature of our human sample, we found that microstructural properties of these tracts are moderately heritable (h2 ∼ 0.5). In a final analysis, we found no evidence of any significant association between subiculum complex-BNST tract microstructure and indices of perceived stress/dispositional negativity and alcohol use, derived from principal component analysis decomposition of self-report data. We did, however, find subiculum complex-BNST tract microstructure associations with BMI, age, and sex. Our findings address a key translational gap in our knowledge of the neurocircuitry regulating stress.

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Aberrant functional connectivity of the bed nucleus of the stria terminalis and its age dependence in children and adolescents with social anxiety disorder

Jin

Liu

et al. 2023

Asian Journal of Psychiatry

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Higher resting-state BNST-CeA connectivity is associated with greater corrugator supercilii reactivity to negatively valenced images

Cited by 16 publications

References 72 publications

Extended‐amygdala intrinsic functional connectivity networks: A population study

Extended‐amygdala intrinsic functional connectivity networks: A population study

Subiculum – BNST Structural Connectivity in Humans and Macaques

Aberrant functional connectivity of the bed nucleus of the stria terminalis and its age dependence in children and adolescents with social anxiety disorder

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