Higher serum 25(OH)D concentrations are associated with improved FEV₁and FVC in adolescence

Abstract

Vitamin D plays a role in the development of the immune system and the lung, as well as in airway remodelling. Therefore, this study investigated the association between serum 25-hydroxyvitamin D (25(OH)D) concentrations and spirometric lung function parameters at age 15 years.In the German birth cohorts GINIplus and LISAplus, lung function testing by spirometry and 25(OH)D measurements were performed during the 15-year follow-up examinations. Valid lung function measurements pre- and/or post-bronchodilation and serum 25(OH)D concentrations, which were adjusted for the date of blood sampling to account for seasonal variability, were available for 2607 adolescents. Associations between 25(OH)D concentrations and spirometric parameters were analysed using generalised additive models adjusted for confounding factors.Serum 25(OH)D concentrations were significantly associated with forced vital capacity (FVC), forced expiratory volume in 1 s (FEV) and FEV/FVC measured before bronchodilation after adjustment for potential confounders: FEV increased by 10 mL (95% CI 2-17), FVC by 20 mL (95% CI 12-28) and FEV/FVC decreased by 0.177% (95% CI -0.286 to -0.067) per 10 nmol·L increase in 25(OH)D concentrations. Flow rates (forced expiratory flow rates at 25, 50 and 75% of exhaled FVC (FEF, FEF, FEF) and mean flow rate between 25 and 75% of FVC (FEF)) were not associated with vitamin D. Similar associations were observed for lung function parameters measured after bronchodilation.Vitamin D concentrations are positively associated with volume-related lung function parameters pre- and post-bronchodilation, suggesting structural changes in peripheral airways.

Serum vitamin D is associated with improved lung function markers but not with prevalence of asthma, emphysema, and chronic bronchitis

“…Another study conducted on 2,607 adolescents aged 15 years found that serum 25(OH)D concentrations were directly associated with FVC and FEV 1 . This association was stronger for FVC than FEV 1 33 . Also in COPD patients, a similar association was found 34 .…”

Which early life events or current environmental and lifestyle factors influence lung function in adolescents? – results from the GINIplus & LISAplus studies

“…We selected factors for investigation based on a short review of the literature, including former GINIplus and LISAplus publications [8, 9, 35, 36], and after considering the number of participants with available data in our cohorts. An overview of investigated covariates is presented in Fig.…”

Association of early life and acute pollen exposure with lung function and exhaled nitric oxide (FeNO). A prospective study up to adolescence in the GINIplus and LISA cohort

“…The total 25(OH)D concentrations in serum were measured by Roche's vitamin D total test on the fully automated Modular system (E170, Roche Diagnostics, Mannheim, Germany). Serum 25(OH)D concentrations were adjusted for the date of blood sampling by fitting a generalised additive model with the residuals then added to the overall mean of the vitamin D concentrations to account for seasonal variability (Flexeder et al, 2017).…”