Higher serum bone alkaline phosphatase as a predictor of mortality in male hemodialysis patients

Kobayashi, Ikue; Shidara, Kaori; Okuno, Senji; Yamada, Shinsuke; Imanishi, Yasuo; Mori, Katsuhito; Ishimura, Eiji; Shoji, Shigeichi; Yamakawa, Tomoyuki; Inaba, Masaaki

doi:10.1016/j.lfs.2011.11.006

Cited by 32 publications

(25 citation statements)

References 32 publications

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“…However, there is limited data on circadian rhythmicity in hemodialysis patients with conflicting results [14,15]. In our study, timing of dialysis was not significantly different between both dialysate calcium groups.…”

Section: Discussioncontrasting

confidence: 62%

Correlations and time course of FGF23 and markers of bone metabolism in maintenance hemodialysis patients

Bielesz

Hecking

Plischke

et al. 2014

Clinical Biochemistry

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Section: Discussioncontrasting

confidence: 62%

Correlations and time course of FGF23 and markers of bone metabolism in maintenance hemodialysis patients

Bielesz

Hecking

Plischke

et al. 2014

Clinical Biochemistry

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“…The kidney expresses ALPL, which is used as a marker for organ function in patients' dialysis (95). High serum levels of ALPL have been associated with paraneoplastic syndrome, as observed in 77 out of 365 patients with stage II-IV renal cell carcinoma, decreasing the 5 year survival to 35.7% (96).…”

Section: Renal Cell and Bladder Cancermentioning

confidence: 99%

The regulatory roles of phosphatases in cancer

et al. 2013

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The relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3 - kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies. © 2014 American Heart Association, Inc

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“…Alkaline phosphatase hydrolyzes pyrophosphate, which is a potent inhibitor of vascular calcification [18,19]. Serum alkaline phosphatase has been reported to predict mortality among hemodialysis patients [20,21]. While most of these studies examined alkaline phosphatase, little is known about bone-specific alkaline phosphatase (BAP) in relation to vascular calcification.…”

Section: Introductionmentioning

confidence: 99%

Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients

Ishimura

Okuno²,

Okazaki³

et al. 2014

Kidney Blood Press Res

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Background/Aims: Bone-specific alkaline phosphatase (BAP) hydrolyzes pyrophosphate, which inhibits vascular calcification. We examined association between serum BAP and vascular calcification of male hemodialysis patients. Methods: Hand roentgenography of 167 male maintenance hemodialysis patients was conducted, and visible vascular calcification of the hand arteries was evaluated. Serum levels of 3 bone formation markers (BAP, osteocalcin, and N-terminal propeptide of type I collagen) and 2 bone resorption markers (C-terminal telopeptide of type I collagen, and cross-linked N-telopeptide of type I collagen) were measured, along with serum intact parathyroid hormone (PTH). Results: Of 167 patients, visible vascular calcification was seen in 37 patients. Among the bone formation and resorption markers, serum BAP was significantly higher in patients with vascular calcification than in those without (p<0.05); although the other 5 serum bone markers were not significantly different between them. Multivariate logistic regression analyses revealed that log [BAP] was significantly associated with vascular calcification after adjustment for age, hemodialysis duration, presence of diabetes, log [intact PTH] and each of the other 5 bone markers (p<0.0001). Conclusions: Higher serum BAP, but not other bone markers, is significantly associated with the presence of vascular calcification in male hemodialysis patients.

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Higher serum bone alkaline phosphatase as a predictor of mortality in male hemodialysis patients

Cited by 32 publications

References 32 publications

Correlations and time course of FGF23 and markers of bone metabolism in maintenance hemodialysis patients

Correlations and time course of FGF23 and markers of bone metabolism in maintenance hemodialysis patients

The regulatory roles of phosphatases in cancer

Significant Association Between Bone-Specific Alkaline Phosphatase and Vascular Calcification of the Hand Arteries in Male Hemodialysis Patients

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