Higher Serum Neuropeptide Y Levels Are Associated with Metabolically Unhealthy Obesity in Obese Chinese Adults: A Cross-Sectional Study

Abstract

Objective. Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity (MHO) phenotype) and the association of NPY with MUO phenotype have not been unequivocally established. We therefore determined associations of serum NPY levels with MUO phenotype in obese Chinese adults. Methods. A cross-sectional study was conducted from 400 obese adults in Hunan province, who underwent a health examination in the Second Xiangya Hospital, and 164 participants were finally enrolled in the study and divided into MHO and MUO groups. Serum NPY levels were examined; univariate and multivariate analyses as well as smooth curve fitting analyses were conducted to measure the association of NPY serum levels with the MUO phenotype. Results. Serum NPY levels were significantly elevated in the MUO group compared with the MHO group ((667.69±292.90) pg/mL vs. (478.89±145.53) pg/mL, p<0.001). A threshold and nonlinear association between serum NPY levels and MUO was found (p=0.001). When serum NPY levels exceeded the turning point (471.5 pg/mL), each 10 pg/mL increment in the NPY serum level was significantly associated with an 18% increased odds ratio of MUO phenotype (OR: 1.18, 95% CI: 1.07–1.29, p=0.0007) after adjusted for confounders. Conclusions. Higher NPY serum levels were positively correlated with MUO phenotype in obese Chinese adults.

Circulating levels of IL-33 are elevated by obesity and positively correlated with metabolic disorders in Chinese adults

“…The software Empower (R) (www.empow ersta ts.com, X & Y Solutions Inc., Boston MA) and R (http://www.Rproje ct.org) [30] were performed for all statistical analyses. Two-tailed p-values less than 0.05 were considered statistically significant.…”

The Association Between Hyperuricemia and Obesity Metabolic Phenotypes in Chinese General Population: A Retrospective Analysis

“…Overweight/obesity is defined as a BMI ≥23 kg/m 2 ( 23 ). Metabolic abnormalities were identified according to criteria established by the Adult Treatment Panel III of the National Cholesterol Education Program (NCEP-ATPIII) ( 24 , 25 ). Participants with two or more of the following four components were considered metabolically abnormal: (1) systolic blood pressure (SBP) ≥130 mmHg or diastolic blood pressure(DBP) ≥85 mmHg (elevated blood pressure); (2) FPG ≥ 5.60 mmol/L (elevated FPG); (3) TG ≥1.7 mmol/L (elevated TG); and (4) HDL-C <1.04 mmol/L in men or <1.29 mmol/L in women (low HDL-C) ( 24 , 25 ).…”

“…Metabolic abnormalities were identified according to criteria established by the Adult Treatment Panel III of the National Cholesterol Education Program (NCEP-ATPIII) ( 24 , 25 ). Participants with two or more of the following four components were considered metabolically abnormal: (1) systolic blood pressure (SBP) ≥130 mmHg or diastolic blood pressure(DBP) ≥85 mmHg (elevated blood pressure); (2) FPG ≥ 5.60 mmol/L (elevated FPG); (3) TG ≥1.7 mmol/L (elevated TG); and (4) HDL-C <1.04 mmol/L in men or <1.29 mmol/L in women (low HDL-C) ( 24 , 25 ). Overweight/obese metabolic phenotypes were defined according to the presence/absence of overweight/obesity and metabolic abnormalities, and all study subjects were classified into four groups: MHNW, MANW, MHOO, and MAOO.…”

Association of dietary phytochemical index with metabolically unhealthy overweight/obesity phenotype among Iranian women: A cross-sectional study

“…This phenotype results from a complex interaction of multiple factors, e.g., genetics, environment, lifestyle, and diet ( 6 , 11 , 12 ). On the contrary, the metabolically unhealthy obesity (MUO) phenotype is connected with at least two or more metabolic disorders and more susceptibility to CVDs ( 13 ). A 10-year follow-up demonstrated that almost half the people with MHO phenotype would develop one or more metabolic abnormalities ( 14 ).…”