The Association Between Hyperuricemia and Obesity Metabolic Phenotypes in Chinese General Population: A Retrospective Analysis

Abstract

PurposeSerum uric acid (UA) not only affects the development of obesity but also alters the metabolic status in obese subjects; thus we investigated the relationship between serum UA and the overweight/obese metabolic phenotypes.MethodsThe demographic, biochemical, and hematological data were collected for 12,876 patients undergoing routine physical examination, and 6,912 participants were enrolled in our study. Participants were classified into four obesity metabolic phenotypes according to their BMI and the presence of metabolic syndrome: metabolically healthy overweight/obese (MHOO), metabolically healthy and normal weighted (MHNW), metabolically abnormal and overweight/obese (MAOO), and metabolically abnormal but normal weighted (MANW). Univariate and multivariate logistic regression analysis, stratified analysis, and also interaction analysis were conducted to analyze the relationship between serum UA and obesity metabolic phenotypes.ResultsMultivariable logistic regression analysis showed that hyperuricemia was positively associated with MHOO, MANW, and MAOO phenotypes relative to MHNW. After adjusting for the confounding factors, the odds ratios (OR) for individuals with hyperuricemia to be MHOO, MANW, and MAOO phenotypes were 1.86 (1.42–2.45), 2.30 (1.44–3.66), and 3.15 (2.34–4.24), respectively. The ORs for having MHOO, MANW, and MAOO increased 6% [OR: 1.06 (1.05–1.07), P < 0.0001], 5% [OR: 1.05 (1.03–1.07), P < 0.0001], and 11% [OR: 1.11 (1.10–1.13), P < 0.0001] for each 10 unit (μmol/L) of increase in serum UA level. Stratification analysis as well as an interaction test showed that sex and age did not interfere with the association of hyperuricemia with each metabolic phenotype. In terms of the components of the metabolic syndrome, after adjusting for other confounding factors including all of the metabolic indicators except itself, hyperuricemia was positively associated with increased BMI [OR: 1.66 (1.32–2.09), P < 0.0001], hypertriglyceridemia [OR: 1.56 (1.21–2.02), P = 0.0006], and hypertension [OR: 1.22 (1.03–1.46), P = 0.0233], while it had no significant association with hyperglycemia and low HDL-C (all P > 0.05).ConclusionIn our study, we discovered that hyperuricemia was positively associated with MHOO, MANW, and MAOO phenotypes, and this relationship was independent of sex and age.

Association between hyperuricemia and metabolic syndrome: A cross-sectional study in Tibetan adults on the Tibetan plateau

“…In the present study, the mean concentration of serum uric acid was 374.8 ± 90.0 umol/L, hyperuricemia was more manifest in male subjects, which is similar to previous studies ( 12 , 34 ). There were 125 (40.7%) subjects with hyperuricemia, much higher than the percentage in Bangladesh (16.6%) and the general Chinese population (8.4–25%) ( 10 , 12 ).…”

“…The present study further showed that hyperuricemia was signifficantly associated with MetS-related variables such as elevated blood pressure, abdominal obesity, and elevated TG but not elevated fasting glucose and reduced HDL-C, which is slightly different from other studies. Many studies have demonstrated a strong association between SUA and various MetS-related components, but the association could be differed by study objects ( 25 , 34 , 35 ). Kim et al.…”

“…Feng et al. suggested that hyperuricemia was associated with elevated TG and elevated blood pressure, but not with elevated FPG and reduced HDL-C ( 34 ). In addition, Tian et al.…”

Association between metabolic obesity phenotype, transition of metabolic phenotypes and the risk of hyperuricemia in Chinese adults: A cohort study

“…[11] A domestic study also came to a similar conclusion that hyperuricemia was positively correlated with the MHOWO, MUNW, and MUHOWO phenotypes, and this association was independent of gender and age. [12] The results of this study also found that the serum uric acid value and the prevalence of hyperuricemia in the MHOWO, MUNW, and MUHOWO groups were higher than those in the MHNW group. Studies have pointed out that this association also has gender differences.…”

Chinese familial central precocious puberty with hyperuricemia due to recurrent DLK1 mutation: Case report and review of the literature

“…Some studies have found that increased fat accumulation in the liver could be induced by uric acid through endoplasmic reticulum stress and upregulation of lipogenesis, and these metabolic alterations may result in obesity. Interestingly, mature adipocytes and adipose tissues were found to be able to produce uric acid (Feng et al, 2022 ). It shows that hyperuricemia is closely related to fat metabolism, and the interaction between them is very complicated.…”