Highlights of Novel Vaccination Strategies in Allergen Immunotherapy

Komlósi, Zsolt István; Kovács, Nóra; Sokołowska, Milena; Veen, Willem van de; Akdiş, Mübeccel

doi:10.1016/j.iac.2019.09.010

Cited by 21 publications

(19 citation statements)

References 74 publications

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“…Increasing safety while maintaining or even increasing efficacy are the main goals of research for novel vaccine development and improvement of treatment schemes in AIT. Perspectives in AIT are well established 181 , and many new products are in development [182][183][184][185] . However, the vast majority of previous attempts failed because safety issues or lack of efficacy was observed.…”

Section: Improved Treatmentmentioning

confidence: 99%

Allergic rhinitis

Bousquet

Antó

Bachert

et al. 2020

Nat Rev Dis Primers

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385

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Section: Improved Treatmentmentioning

confidence: 99%

Allergic rhinitis

Bousquet

Antó

Bachert

et al. 2020

Nat Rev Dis Primers

521

385

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“…So far, researchers and clinicians have focused on four major application routes of AIT, namely oral immunotherapy (OIT), sublingual immunotherapy (SLIT), subcutaneous immunotherapy (SCIT) and epicutaneous immunotherapy (EPIT) for the treatment of food allergies. In most cases, different routes and/or doses of AIT delivery results in similar immunologic changes (3,4). During the last decade, OIT, SCIT, and SLIT have been widely evaluated in clinical trials for FA-AIT, while EPIT has been predominantly tested in a preclinical setting (1, 5) until very recently when wellpowered clinical trials began to occur (6).…”

Section: Introductionmentioning

confidence: 99%

Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy

et al. 2020

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“…In the era of molecular diagnosis and treatments, new AIT approaches are being developed to decrease the allergenicity and adverse effects, as well as shorten the duration of the convectional AIT [ 28 , 29 ]. To achieve this, studies have been conducted on the use of hypoallergens, recombinant proteins, and methods other than subcutaneous and sublingual administration are under studying [ 30 ].…”

Section: Peptide Allergen Immunotherapy: State Of the Artmentioning

confidence: 99%

Peptide Allergen Immunotherapy: A New Perspective in Olive-Pollen Allergy

et al. 2021

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Allergic diseases are highly prevalent disorders, mainly in industrialized countries where they constitute a high global health problem. Allergy is defined as an immune response “shifted toward a type 2 inflammation” induced by the interaction between the antigen (allergen) and IgE antibodies bound to mast cells and basophils that induce the release of inflammatory mediators that cause the clinical symptoms. Currently, allergen-specific immunotherapy (AIT) is the only treatment able to change the course of these diseases, modifying the type 2 inflammatory response by an allergenic tolerance, where the implication of T regulatory (Treg) cells is considered essential. The pollen of the olive tree is one of the most prevalent causes of respiratory allergic diseases in Mediterranean countries, inducing mainly nasal and conjunctival symptoms, although, in areas with a high antigenic load, olive-tree pollen may cause asthma exacerbation. Classically, olive-pollen allergy treatment has been based on specific immunotherapy using whole-olive pollen extracts. Despite extracts standardization, the effectiveness of this strategy varies widely, therefore there is a need for more effective AIT approaches. One of the most attractive is the use of synthetic peptides representing the B- or T-cell epitopes of the main allergens. This review summarizes experimental evidence of several T-cell epitopes derived from the Ole e 1 sequence to modulate the response to olive pollen in vitro, associated with several possible mechanisms that these peptides could be inducing, showing their usefulness as a safe preventive tool for these complex diseases.

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Highlights of Novel Vaccination Strategies in Allergen Immunotherapy

Cited by 21 publications

References 74 publications

Allergic rhinitis

Allergic rhinitis

Immunological Outcomes of Allergen-Specific Immunotherapy in Food Allergy

Peptide Allergen Immunotherapy: A New Perspective in Olive-Pollen Allergy

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