Highly accurate and label-free discrimination of single cancer cell using a plasmonic oxide-based nanoprobe

Zhang, Baoyue; Yin, Pengju; Hu, Yihong; Szydzik, Crispin; Khan, Muhammad Waqas; Xu, Kai; Thurgood, Peter; Mahmood, Nasir; Dekiwadia, Chaitali; Afrin, Sanjida; Yang, Yunyi; McConville, Christopher F; Khoshmanesh, Khashayar; Mitchell, Arnan; Hu, Bo; Baratchi, Sara; Ou, Jian Zhen

doi:10.1016/j.bios.2021.113814

Cited by 16 publications

(25 citation statements)

References 52 publications

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“…[ 121 ] In addition, the current review shows that Pd binary or ternary alloys can also be used to significantly improve the performance of PHS, but systematic studies on the fabrication and optical properties of these or other alloys are rare. Other than the conventional plasmonic materials (noble metal), new materials, such as degenerate semiconductors, [ 122–124 ] emerge for plasmonic sensors and show impressive performances in gas and ion detection. These new plasmonic materials may offer great potential in PHS.…”

Section: Discussionmentioning

confidence: 99%

Plasmonic Hydrogen Sensors

Sun

Zhao

2022

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Hydrogen is regarded as the ultimate fuel and energy carrier with a high theoretical energy density and universality of sourcing. However, hydrogen is easy to leak and has a wide flammability range in air. For safely handling hydrogen, robust sensors are in high demand. Plasmonic hydrogen sensors (PHS) are attracting growing interest due to the advantages of high sensitivity, fast response speed, miniaturization, and high‐degree of integration, etc. In this review, the mechanism and recent development (mainly after the year 2015) of hydrogen sensors based on plasmonic nanostructures are presented. The working principle of PHS is introduced. The sensing properties and the effects of resonance mode, configuration, material, and structure of the plasmonic nanostructures on the sensing performances are discussed. The merit and demerit of different types of plasmonic nanostructures are summarized and potential development directions are proposed. The aim of this review is not only to clarify the current strategies for PHS, but also to give a comprehensive understanding of the working principle of PHS, which may inspire more ingenious designs and execution of plasmonics for advanced hydrogen sensors.

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Section: Discussionmentioning

confidence: 99%

Plasmonic Hydrogen Sensors

Sun

Zhao

2022

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“…This journal is © The Royal Society of Chemistry 2022 bio-applications including bioimaging, 50,51 bio-thermal therapy, 50,52,53 surface-enhanced Raman scattering (SERS) spectroscopy, 54,55 and biomolecule sensing. 56,57 Furthermore, it is noted that the plasmonic features of MOs are enabled by the structural vacancies or external dopants which can be inserted or extracted through reaction with the ambient environment.…”

Section: Farjana Haquementioning

confidence: 99%

“…50,122,150,[158][159][160][161] Besides the selfdoped MoO 3Àx , intercalating extrinsic ions (i.e., H + ) into the structure can also enhance the free electron concentration and initialize the LSPR performance. 55,59,162 Plasmonic MoO 3 nanomaterials have become popular after Huang reported the NIR LSPR absorption band of substoichiometric MoO 3Àx in 2012. 49 These atomically thin nanosheets exhibit a distinct blue color (Fig.…”

Section: Doped Molybdenum Oxidementioning

confidence: 99%

“…Various doped MO NSs, including titanium oxide, tungsten oxide, and molybdenum oxide, etc., have been demonstrated in the SERS effect using different Raman probes. 54,55,119,136,169,[270][271][272][273][274][275][276][277] Cong et al firstly reported the SERS effect of semiconductor materials -oxygen-deficient WO 2.72 (W 18 O 49 ) nanowires. 270 The urchin-shaped WO 2.72 with rich surface oxygen vacancies gave rise to an EF of 3.4 Â 10 5 and an LOD of 10 À7 M. Doped molybdenum oxide has been explored as a SERS substrate as well.…”

Section: Sers Based Biosensingmentioning

confidence: 99%

“…In addition to dyes, researchers have validated the detection of other bioactive molecules and cells using plasmonic MObased SERS. 55,136,277 To examine the potential to detect multiple components simultaneously, 274 researchers have explored MO SERS in non-destructive cancer cell detection. Recently, quantum scale structured TiO x with oxygen vacancies has been applied as a SERS substrate which achieved an LOD of 1 nM and a maximum EF of 3.4 Â 10 7 .…”

Section: Sers Based Biosensingmentioning

confidence: 99%

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Plasmonic metal oxides and their biological applications

Zhang

Haque

et al. 2022

Mater. Horiz.

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Complex Refractive Index Extraction for Ultrathin Molybdenum Oxides Using Micro‐Photonic Integrated Circuit Chips

Hu,

Ma,

Zhang

et al. 2023

Advanced Optical Materials

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The emerging 2D nanomaterials with unique optical properties are promising for next‐generation miniatured on‐chip devices. One of the prerequisites is to precisely measure their optical parameters during their implementation. However, the inherent features of 2D layers, including limited lateral dimensions and ultra‐small thicknesses, are not favorable to the conventional characterization techniques applied in the bulk system, especially for optical complex refractive indices measurement. Here, this work proposes a silicon photonics‐enabled platform to evaluate the complex refractive indices of ultrathin 2D materials in a facile and reliable manner. Ultrathin molybdenum oxides (MoOx) with multiple stoichiometric states are selected as the target 2D material to provide sufficient complexity of the system for investigation. Upon the integration of ultrathin MoOx, the silicon photonic chip, in the form of a Mach‐Zehnder interferometer, exhibits wavelength shifts which are used for calculating the optical complex refractive indices. Compared with the theoretical calculation, the deviation is as low as 1% and generally less than 5%. This work demonstrates a highly accurate and reliable approach for measuring the complex refractive index of 2D films, possibly assisting future advances in 2D materials‐enabled optical and photonic applications.

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Highly accurate and label-free discrimination of single cancer cell using a plasmonic oxide-based nanoprobe

Cited by 16 publications

References 52 publications

Plasmonic Hydrogen Sensors

Plasmonic Hydrogen Sensors

Plasmonic metal oxides and their biological applications

Complex Refractive Index Extraction for Ultrathin Molybdenum Oxides Using Micro‐Photonic Integrated Circuit Chips

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