Highly-cited estimates of the cumulative incidence and recurrence of vulvovaginal candidiasis are inadequately documented

Rathod, Sujit D; Buffler, Patricia A.

doi:10.1186/1472-6874-14-43

Cited by 34 publications

(32 citation statements)

References 69 publications

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“…is affected by the immune status of the host, lower body resistance, pH changes in the vagina, lifestyle, abuse of antibiotics and pregnancy (10, 11). In our study, the overall positivity rate of Candida infection was 22.45%, of which C. albicans was the main species identified.…”

Section: Discussionmentioning

confidence: 99%

Distribution and Drug Susceptibility of Candida spp. Associated With Female Genital Tract Infection, Chongqing, China

Luo

Dong

Pen

2015

Jundishapur J Microbiol

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BackgroundVulvovaginal candidiasis is defined as vulvovaginitis associated with vaginal carriage of Candida spp. and is a common problem with a high rate of morbidity.ObjectivesTo investigate the distribution of Candida spp. and evaluate the corresponding antifungal susceptibility in women with genital tract infection in Chongqing, southwestern China.Patients and MethodsSamples (n = 2.129) were obtained from female patients with symptoms of genital tract infection. Candida spp. were isolated from the specimens and were identified using a coloration medium and the VITEK 2 Compact automatic microbial identification system. Antifungal susceptibility testing was performed using the ATB FUNGUS drug susceptibility testing system.ResultsFrom 2,129 samples, 478 (22.45%) isolates of Candida were isolated, of which 395 (82.64%) were Candida albicans, 39 (8.16%) were C. glabrata, 21 (4.39%) were C. tropicalis, 9 (1.88%) were C. parapsilosis, and 14 (2.93%) were other Candida spp. The resistance of C. albicans, C. glabrata, and C. tropicalis to 5 antifungal drugs (amphotericin B, voriconazole, fluconazole, 5-fluorocytosine, and itraconazole) ranged from 0.5% to 6.4%, 0% to 7.7%, and 0% to 9.6%, respectively.ConclusionsCandida albicans was the major pathogen associated with candidiasis of the female genital tract in patients in Chongqing. The results of the antifungal sensitivity of the isolates suggest that it is important for clinicians to administer appropriate antifungals for the treatment of Candida spp. infections.

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Section: Discussionmentioning

confidence: 99%

Distribution and Drug Susceptibility of Candida spp. Associated With Female Genital Tract Infection, Chongqing, China

Luo

Dong

Pen

2015

Jundishapur J Microbiol

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“…Recurrent attacks of vulvovaginal candidiasis have been estimated to affect 5-10% of women annually [58,59], primarily based on data from Foxman et al [36,37] (Table 2). Estimates of rVVC are intrinsically difficult to conduct to reliably estimate the incidence and prevalence of rVVC among women [59].There are no reports of rVVC from East Africa, but a study in Tunisia found a similar prevalence of 6.1% [60].…”

Section: Candida Infectionsmentioning

confidence: 99%

The Burden of Fungal Infections in Ethiopia

Tufa¹,

Denning

2019

JoF

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The burden of severe fungal infections (FIs) is not well addressed in Ethiopia. We have estimated the burden of FIs from multiple demographic sources and by searching articles from PubMed. Opportunistic FIs were estimated using modelling and 2017 national HIV data. The burdens of chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA) were estimated by using the prevalence of asthma, chronic obstructive pulmonary disease, and annual the incidence of tuberculosis. Of the 105,000,000 estimated Ethiopian population, 610,000 are thought to have HIV infection. Our estimation of HIV-related FIs were: 9900 cryptococcal meningitis (CM), 12,700 Pneumocystis jirovecii pneumonia (PCP), 76,300 oral and 56,000 oesophageal candidiasis cases. A remarkable 7,051,700 4–14-year-olds probably have tinea capitis and 1,469,000 women probably have recurrent Candida vaginitis. There were 15,200 estimated CPA cases (prevalence) and 11,500 invasive aspergillosis (IA) cases (incidence). Data are scant, but we estimated 5300 candidaemia and 800 Candida peritonitis cases. In conclusion, approximately 8% of Ethiopians suffer from FIs annually, mostly schoolchildren with tinea capitis. IA, CM and PCP are the major causes of fungal deaths. The absence of CD4 count is challenging the identification of HIV patients at risk of opportunistic FIs. There is a pressing need to improve FI diagnosis, probably including national surveillance.

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“…(4,5) This is firstly a consequence of the widespread availability of over the counter (OTC) antifungal agents. Procurement of the easily available, numerous highly effective topical antimycotic agents, although controversial, can be considered a boon to womens health.…”

Section: Introductionmentioning

confidence: 99%