Highly crosslinked ionic β-cyclodextrin polymers and their interaction with heavy metals

Berto, Silvia; Bruzzoniti, Maria Concetta; Cavalli, Roberta; Perrachon, D.; Prenesti, Enrico; Sarzanini, Corrado; Trotta, Francesco; Tumiatti, W.

doi:10.1007/s10847-006-9270-3

Cited by 39 publications

(26 citation statements)

References 11 publications

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“…From an environmental standpoint this means that water pollutants, such as heavy metals and many organic molecules, can be removed and retained easily [24–25]. …”

Section: Reviewmentioning

confidence: 99%

Cyclodextrin-based nanosponges as drug carriers

Trotta¹,

Zanetti²,

Cavalli³

2012

Beilstein J. Org. Chem.

303

219

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SummaryCyclodextrin-based nanosponges, which are proposed as a new nanosized delivery system, are innovative cross-linked cyclodextrin polymers nanostructured within a three-dimensional network. This type of cyclodextrin polymer can form porous insoluble nanoparticles with a crystalline or amorphous structure and spherical shape or swelling properties. The polarity and dimension of the polymer mesh can be easily tuned by varying the type of cross-linker and degree of cross-linking. Nanosponge functionalisation for site-specific targeting can be achieved by conjugating various ligands on their surface. They are a safe and biodegradable material with negligible toxicity on cell cultures and are well-tolerated after injection in mice. Cyclodextrin-based nanosponges can form complexes with different types of lipophilic or hydrophilic molecules. The release of the entrapped molecules can be varied by modifying the structure to achieve prolonged release kinetics or a faster release. The nanosponges could be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems or design innovative drug carriers for nanomedicine.

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“…From an environmental standpoint this means that water pollutants, such as heavy metals and many organic molecules, can be removed and retained easily [24–25]. …”

Section: Reviewmentioning

confidence: 99%

Cyclodextrin-based nanosponges as drug carriers

Trotta¹,

Zanetti²,

Cavalli³

2012

Beilstein J. Org. Chem.

303

219

View full text Add to dashboard Cite

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“…␤-CD polymer has been reported to be efficient in adsorption toward organic pollutants and heavy metals in water [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]. This kind of polymer is usually synthesized by reacting ␤-CDs with crosslinking agents such as epichlorohydrin [9][10][11][12][13], diisocyanates [14][15][16], polycarboxylic acids [17][18][19] and anhydrides [20][21][22]. Polycarboxylic acids, such as citric acid [23], are generally of low toxicity and friendly to environment.…”

Section: Introductionmentioning

confidence: 99%

Comparative study of polymer containing β-cyclodextrin and –COOH for adsorption toward aniline, 1-naphthylamine and methylene blue

Zhao

Chen

et al. 2009

Journal of Hazardous Materials

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“…As has been reported, b-CD polymers can effectively adsorb organic molecules and heavy metals in water [8][9][10][11][12][13][14][15][16][17][18][19][20]. b-CD polymers modified by carboxyl/carboxylate groups (-COOH/-COO -) have been found to be more efficient in adsorption toward some heavy metals, basic dyes and aromatic amines [21][22][23][24][25][26][27][28][29][30]. The improvements are ascribed to the chemical adsorption properties of carboxyl/ carboxylate groups.…”

Section: Introductionmentioning

confidence: 99%

A novel β-cyclodextrin polymer modified by sulfonate groups

Zhao

Zhu

et al. 2011

J Incl Phenom Macrocycl Chem

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Based on the special properties and advantages of b-cyclodextrin (b-CD), b-CD polymers have been widely studied and used in recent years. A lot of researches have focused on the adsorption and separation properties of b-CD polymers. In this paper, b-CD polymer modified by sulfonate groups, which was named S-b-CDP, was prepared using epichlorohydrin as crosslinker and tiron (1,2-dihydroxybenzene-3,5-disulfonic acid disodium salt) as modifier. b-CD polymer without modification, which was named b-CDP, was also prepared for comparison. Infrared spectra, elemental analysis and adsorption tests of S-b-CDP were carried out and compared with b-CDP. The content of sulfonate groups in S-b-CDP was obtained from elemental analysis. The dramatically increased adsorption capability toward methylene blue and basic magenta confirmed the existence and chemical activity of sulfonate groups in S-b-CDP. Due to the convenient preparation process and modified adsorption properties, S-b-CDP will find its applications in various fields such as water purification, drug loading, separation and analysis.

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Highly crosslinked ionic β-cyclodextrin polymers and their interaction with heavy metals

Cited by 39 publications

References 11 publications

Cyclodextrin-based nanosponges as drug carriers

Cyclodextrin-based nanosponges as drug carriers

Comparative study of polymer containing β-cyclodextrin and –COOH for adsorption toward aniline, 1-naphthylamine and methylene blue

A novel β-cyclodextrin polymer modified by sulfonate groups

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