“…Engineered heme proteins such as cytochrome P450 enzymes, myoglobin, and cyctochrome C have emerged as excellent catalysts for new‐to‐nature reactions,1, 2 including carbene‐transfer reactions such as cyclopropanations,3, 4, 5, 6, 7 olefinations, and8, 9 N−H,10, 11 Si−H,12 and B−H insertion reactions 13. These enzymes have proven amenable to optimization by both genetic methods and co‐factor replacement 14, 15, 16, 17, 18, 19, 20.…”