Highly diastereo- and enantioselective synthesis of multisubstituted allylic amino acid derivatives by allylic alkylation of a chiral glycine-based nickel complex and vinylethylene carbonates

Abstract

The asymmetric synthesis of multisubstituted allylic amino acid derivatives was accomplished by the allylic alkylation of a chiral glycine-based nickel complex with vinylethylene carbonates. The high level enantioselectivities and diastereoselectivities...

Regio- and stereoselective syntheses of chiral α-quaternary (Z)-trisubstituted allylic amino acidsviasynergistic Pd/Cu catalysis

“…11–16 To the best of our knowledge, methods by attacking the terminal position of intermediate C for the construction of chiral functionalized products with the ( Z )-configuration are still scarce and underdeveloped. 17 A single catalytic style mode was difficult to control the chiral stereo center owing to the long distance of the prochiral center with the π-allylpalladium intermediate. Another point probably worthy of note is that this substrate-dependent selectivity has hampered the development of the regioselectivity of allylic reaction by a single-catalyst system.…”