Highly effective antibiofilm coating of silver–polymer nanocomposite on polymeric medical devices deposited by one step plasma process

Abstract

Foley's catheters were coated with Silver (Ag), plasma polymerized aniline (PPAni) and Ag-PPAni composite by plasma based deposition processes which were characterized by XRD, EDX, SEM, and FT-IR spectroscopy and bioassays were performed to validate their efficacies to kill planktonic cells as well as to remove biofilm. The analyses confirmed the formation of Ag nanoparticles (AgNPs), PPAni and Ag-PPAni composite and also corroborated their successful deposition over the catheters. Antibacterial assays showed that coated catheters were capable of killing planktonic cells of most commonly encountered uropathogens and equally capable of eradicating biofilm formation by the uropathogens as evident from the reduced cfu/ml. UV-vis spectroscopy results showed that the nanoparticle coated catheters were capable of gradual release of AgNPs, killing all planktonic cells in solution over the time. Foley's catheters coated with AgNPs and their composites by one step plasma process were non-toxic devices capable of killing planktonic cells and proficient in eradicating biofilm formation which could be used to cutback the likelihood of the catheter related complications.

Antifouling coating with controllable and sustained silver release for long‐term inhibition of infection and encrustation in urinary catheters

“…We hypothesize that, firstly, the amount of silver loaded and its subsequent release profile can be readily controlled by manipulating the number of silver-containing layers, and secondly, the outer antifouling layer will ensure free diffusion of the silver by preventing deposition of a conditioning film on the coating. Thus, our coating differs from coatings prepared in earlier investigations, 16,18 where silver was either blended into the coating or sputtered on the catheter, and to the best of our knowledge, such a two-pronged strategy to achieve long-term antibacterial and anti-encrustation efficacy has not been applied to coatings for urinary devices. The above-mentioned multilayered coating was constructed on silicone catheters with polydopamine (PDA) as the surface anchor since it can be coated onto almost any surface.…”

“…15 Silver nitrate-coated stents, electrified silver wire-connected catheters, and silver-polymer nanocomposite deposited catheters have been reported to inhibit bacterial growth and encrustation. [16][17][18] However, commercially available silver-coated urinary catheters have not been successful in preventing bacterial infection and encrustation. 11,[19][20][21] One possible reason for their failure is the limited release of silver from the Additional Supporting Information may be found in the online version of this article.…”

Silver Nanocoating Technology in the Prevention of Prosthetic Joint Infection

“…Moreover, AgNPs have a strong anti-biofilm potential [162,166,167,168,169,170,171,172,173,174,175,176,177,178,179]. Therefore, these are potentially very attractive for surface protection of orthopaedic implants since PJI is biofilm driven in the majority of clinical cases.…”

Nonconventional Routes to Silver Nanoantimicrobials

“…Silver-based antimicrobials and AgNPs have been proposed for catheter impregnation and resulted in effective prevention of early bacterial colonization (Beattie and Taylor, 2011;Agarwala et al, 2014). Since 1999, numerous studies of the incorporation of AgNPs in the catheter matrix have been published, wherein the substantial reduction of bacterial colonization has been assessed (Bö swald et al, 1999;Hentschel and Mü nstedt, 1999;Joyce-Wö hrmann and Mü nstedt, 1999;Martus et al, 1999;Rösch and Lugauer, 1999;Schoerner et al, 1999;Samuel and Guggenbichler, 2004).…”