Highly efficient and flexible preparation of water-dispersed Fe3O4 nanoclusters using a micromixer

Liu, Xiaojing; Lu, Yangcheng

doi:10.1016/j.partic.2018.06.003

Cited by 9 publications

(6 citation statements)

References 46 publications

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“…Increasing the size of magnetic nanoparticles will increase the saturation magnetization but will lead to the transformation of nanoparticles from superparamagnetic to ferromagnetic. The assembly of nanoparticles sufficiently interferes with the magnetic interactions between the crystals to inhibit this transition. , Nanoparticle clusters are assembled through dipole interactions between particles, and unnecessary aggregation is prevented by the steric repulsion of surface stabilizers. , The manipulation of this structure combines the superparamagnetic properties of the individual nanoparticles and integrates the magnetization of the nanoparticle to significantly enhance the magnetic responses of the entire clusters. Iron oxide nanoparticle clusters (IONCs) are assembled from IONPs, which are advantageous because of their extremely strong magnetic responses and the retaining of superparamagnetic properties of individual particles.…”

Section: Introductionmentioning

confidence: 99%

“…The assembly of nanoparticles sufficiently interferes with the magnetic interactions between the crystals to inhibit this transition. 28,29 Nanoparticle clusters are assembled through dipole interactions between particles, and unnecessary aggregation is prevented by the steric repulsion of surface stabilizers. 2,30 The manipulation of this structure combines the superparamagnetic properties of the individual nanoparticles and integrates the magnetization of the nanoparticle to significantly enhance the magnetic responses of the entire clusters.…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible Superparamagnetic Europium-Doped Iron Oxide Nanoparticle Clusters as Multifunctional Nanoprobes for Multimodal In Vivo Imaging

Zhang

Wang

Xiang

et al. 2021

ACS Appl. Mater. Interfaces

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Magnetic nanoparticle clusters composed of primary magnetic nanoparticles can not only significantly enhance the magnetic properties of the assembly but also retain the superparamagnetic properties of the individual primary nanoparticle, which is of great significance for promoting the development of multifunctional advanced materials. Herein, water-soluble biocompatible and superparamagnetic europium-doped iron oxide nanoparticle clusters (EuIO NCs) were directly synthesized by a simple one-pot method. The obtained EuIO NCs have excellent water solubility, colloidal stability, and biocompatibility. Europium doping significantly improved the contrast enhancement effect of EuIO NCs in T 1-weighted MR imaging. In addition, EuIO NCs can be functionalized by active molecules, and the rhodamine123-functionalized EuIO NCs have long circulation time and excellent fluorescence imaging performance in vivo. This study provides a simple strategy for the design and construction of a novel multifunctional magnetic nanoplatform and provides solutions for the development of multimodal imaging probes and the diagnosis of disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biocompatible Superparamagnetic Europium-Doped Iron Oxide Nanoparticle Clusters as Multifunctional Nanoprobes for Multimodal In Vivo Imaging

Zhang

Wang

Xiang

et al. 2021

ACS Appl. Mater. Interfaces

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“…The agglomeration caused by the interaction between nanoparticles is a rapid and sensitive process that requires efficient control methods. In our previous work, water-dispersible Fe 3 O 4 nanoclusters were obtained via a micromixer, which could realize rapid solvent exchange and accurate size control [ 33 ]. This method benefited from the outstanding mixing performance of the micromixer, which could achieve the even and sufficient allocation of surfactant in a short time.…”

Section: Introductionmentioning

confidence: 99%

Flexible and Effective Preparation of Magnetic Nanoclusters via One-Step Flow Synthesis

Zhou

Lü

2022

Nanomaterials

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Fe3O4 nanoclusters have attractive applications in various areas, due to their outstanding superparamagnetism. In this work, we realized a one-step flow synthesis of Fe3O4 nanoclusters, within minutes, through the sequential and quantitative introduction of reactants and modifier in a microflow system. The enhanced micromixing performance enabled a prompt and uniform supply of the modifier oleic acid (OA) for both nanoparticle modification and nanocluster stabilization to avoid uncontrolled modified nanoparticles aggregation. The size of the nanoclusters could be flexibly tailored in the range of 50–100 nm by adjusting the amount of OA, the pH, and the temperature. This rapid method proved the possibility of large-scale and stable production of magnetic nanoclusters and provided convenience for their applications in broad fields.

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“…In the particular case of iron oxide syntheses, different strategies have already been developed, but they involve the design of complex reactors (micromixers, multiphasic reactors) [ 17 , 18 ], the use of special methodologies (gas slugs, water-in-oil droplets) [ 8 , 19 , 20 ] or are only suitable for temperatures below 100 °C [ 10 , 21 , 22 , 23 , 24 ] which strongly limits the possibility to obtain highly crystalline NPs. However, such reactors could advance the field of high-temperature materials science syntheses, for which heat transfer and temperature homogeneity govern the physico-chemical features of the as-synthetized nanomaterials.…”

Section: Introductionmentioning

confidence: 99%

High Temperature Continuous Flow Syntheses of Iron Oxide Nanoflowers Using the Polyol Route in a Multi-Parametric Millifluidic Device

2021

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One of the most versatile routes for the elaboration of nanomaterials in materials science, including the synthesis of magnetic iron oxide nanoclusters, is the high-temperature polyol process. However, despite its versatility, this process still lacks reproducibility and scale-up, in addition to the low yield obtained in final materials. In this work, we demonstrate a home-made multiparametric continuous flow millifluidic system that can operate at high temperatures (up to 400 °C). After optimization, we validate its potential for the production of nanomaterials using the polyol route at 220 °C by elaborating ferrite iron oxide nanoclusters called nanoflowers (CoFe2O4, Fe3O4, MnFe2O4) with well-controlled nanostructure and composition, which are highly demanded due to their physical properties. Moreover, we demonstrate that by using such a continuous process, the chemical yield and reproducibility of the nanoflower synthesis are strongly improved as well as the possibility to produce these nanomaterials on a large scale with quantities up to 45 g per day.

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Highly efficient and flexible preparation of water-dispersed Fe3O4 nanoclusters using a micromixer

Cited by 9 publications

References 46 publications

Biocompatible Superparamagnetic Europium-Doped Iron Oxide Nanoparticle Clusters as Multifunctional Nanoprobes for Multimodal In Vivo Imaging

Biocompatible Superparamagnetic Europium-Doped Iron Oxide Nanoparticle Clusters as Multifunctional Nanoprobes for Multimodal In Vivo Imaging

Flexible and Effective Preparation of Magnetic Nanoclusters via One-Step Flow Synthesis

High Temperature Continuous Flow Syntheses of Iron Oxide Nanoflowers Using the Polyol Route in a Multi-Parametric Millifluidic Device

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