Highly efficient one-pot three-component Betti reaction in water using reverse zinc oxide micelles as a recoverable and reusable catalyst

Mou, Jie; Gao, Gan; Chen, Chen; Liu, Jie; Gao, Jian; Liu, Yi; Pei, Dong‐Sheng

doi:10.1039/c6ra28599f

Cited by 37 publications

(15 citation statements)

References 32 publications

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“…Pei et al 100 reported a highly efficient one-pot threecomponent Betti reaction using reverse ZnO micelles as a recoverable and reusable catalyst. Reactions were conducted with 2-naphthol, aromatic aldehydes, amines and reverse ZnO nanomicelles (10 mol%) in water at room temperature within 4-60 min, affording Betti base derivatives 134 in 29-96% yields (Scheme 91).…”

Section: Synthesis and Synthetic Applications Of Betti Base Derivativesmentioning

confidence: 99%

Recent advances in the synthesis and synthetic applications of Betti base (aminoalkylnaphthol) and bis-Betti base derivatives

Olyaei

Sadeghpour

2019

RSC Adv.

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Section: Synthesis and Synthetic Applications Of Betti Base Derivativesmentioning

confidence: 99%

Recent advances in the synthesis and synthetic applications of Betti base (aminoalkylnaphthol) and bis-Betti base derivatives

Olyaei

Sadeghpour

2019

RSC Adv.

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“…ZnO NPs were synthesized using the modified reversed-phase microemulsion method which utilized zinc acetate as precursor (Mou et al., 2017). Briefly, hexadecyl trimethyl ammonium bromide (CTAB, 0.3644 g, 1 mmol) was dissolved in cyclohexane (10 mL).…”

Section: Methodsmentioning

confidence: 99%

Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation

Mou

Liu

et al. 2019

Drug Delivery

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Periodontal disease is a complex problem which often interrelates with several serious systemic diseases. However, the satisfactory clinical therapy has yet to be achieved. Herein, serum albumin microspheres containing minocycline and zinc oxide nanoparticals (ZnO NPs) were prepared and incorporated in a Carbopol 940 ® hydrogel. Compared with 2% minocycline ointment (Perio ® ), the hydrogel has shown obvious therapy effects and the ability of gingival tissue self-repairing. The serum albumin microspheres containing 0.06% of minocycline and 0.025% of ZnO NPs presented an average size of 139 ± 0.42 nm using electrophoretic light scattering ( n = 3). Photomicrographs obtained by TEM showed homogeneous and spherical-shaped particles. The encapsulation efficiency was 99.99% for minocycline and the slow-release time was more than 72 h with pH-sensitive property. The in vitro skin adhesion experiment showed that the largest bioadhesive force is 0.35 N. Moreover, the hydrogel showed broad-spectrum antimicrobial and effective antibacterial ability when concentration of the ZnO NPs was over 0.2 µg/mL. The cell survival rates were more than 85% below 0.8 mg/L of ZnO NPs, which proved its low toxicity and high security.

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“…The reverse zinc oxide nanomicelles was synthesized following the reported procedure (Mou et al, 2017) (Scheme 2). Reverse micelles were formed by the self-assembly of the surfactant in cyclohexane.…”

Section: Preparation and Characterization Of Catalystmentioning

confidence: 99%

“…Our previous studies have shown that the Betti reaction could be promoted by reverse zinc oxide micelles in aqueous efficiently and selectively (Mou et al, 2017). As interest continues in the potential use of such a catalyst, we report herein a simple, one-pot synthesis of 2-substituted 2,3-dihydroquinazolin-4(1H)-one from substituted aldehydes and anthranilamide in the presence of reverse zinc oxide micelles as a catalytic system (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

An Aqueous Facile Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives by Reverse Zinc Oxide Micelles as Nanoreactor

et al. 2020

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A green synthetic protocol has been developed for the efficient preparation of 2,3-dihydroquinazolin−4(1H)-one derivatives with excellent yield in aqueous media. Reverse zinc oxide micelles catalyzed the reactions efficiently and selectively as the hallow nanoreactor. Moreover, the catalyst was reusable without significant loss of catalytic efficiency. The notable advantages of the procedure are high yields and mild reaction conditions, simple operation, nonchromatographic purification, environmentally friendly and good versatile substrates.

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Highly efficient one-pot three-component Betti reaction in water using reverse zinc oxide micelles as a recoverable and reusable catalyst

Abstract: An efficient synthesis of Betti basesviaa one-pot three-component reaction of 2-naphthol, substituted aldehydes and anilines in aqueous media is reported.

Cited by 37 publications

References 32 publications

Recent advances in the synthesis and synthetic applications of Betti base (aminoalkylnaphthol) and bis-Betti base derivatives

Recent advances in the synthesis and synthetic applications of Betti base (aminoalkylnaphthol) and bis-Betti base derivatives

Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation

An Aqueous Facile Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives by Reverse Zinc Oxide Micelles as Nanoreactor

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