Highly facilitated synthesis of phenyl(tetramethyl)acridinedione pharmaceuticals by a magnetized nanoscale catalytic system, constructed of GO, Fe3O4 and creatine

Eyvazzadeh-Keihan, Reza; Bahrami, Negar; Taheri‐Ledari, Reza; Maleki, Ali

doi:10.1016/j.diamond.2019.107661

Cited by 39 publications

(17 citation statements)

References 45 publications

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“…The broad peak observed in region 3421 cm −1 is related to the stretching vibration of the hydroxyl group of graphene oxide and lignin [22,31,49]. Peaks in the 1722 cm −1 and 1225 cm −1 regions may represent the stretching modes of carbonyl and C-O-C groups in the graphene oxide structure, respectively [22,50].…”

Section: -Results and Discussionmentioning

confidence: 99%

Graphene Oxide-Lignin/Silk Fibroin/ZnO Nanobiocomposite: A Novel Bioactive Scaffold With Antibacterial Activity

Eivazzadeh‐Keihan

Zare-Bakheir

Aliabadi

et al. 2021

Preprint

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In this study, a novel nanobiocomposite was synthesized using graphene oxide, lignin, silk fibroin and ZnO and used in biological fields. To synthesize this structure, after preparing graphene oxide by the Hummer method, lignin, silk fibroin, and ZnO nanoparticles (NPs) were added to it, respectively. Also, ZnO NPs with a particle size of about 18 nm to 33 nm was synthesized via Camellia sinensis extract by green methodology. The synthesized structure was examined as anti-biofilm agent and it was observed that the Graphene oxide-lignin/silk fibroin/ZnO nanobiocomposite has a significant ability to prevent the formation of P. aeruginosa biofilm. In addition, due to the importance of the possibility of using this structure in biological environments, its toxicity and blood compatibility were also evaluated. According to the obtained results from MTT assay, the viability percentages of Hu02 cells treated with Graphene oxide-lignin/silk fibroin/ZnO nanobiocomposite after 24, 48, and 72 h of incubation were 89.96%, 89.32%, and 91.28%. On the other hand, the hemolysis percentage of the synthesized structure after 24 h and 72 h of extraction was 9.5% and 11.76% respectively. As a result, the synthesized structure is hemocompatible and had no toxic effects on Hu02 cells.

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Section: -Results and Discussionmentioning

confidence: 99%

Graphene Oxide-Lignin/Silk Fibroin/ZnO Nanobiocomposite: A Novel Bioactive Scaffold With Antibacterial Activity

Eivazzadeh‐Keihan

Zare-Bakheir

Aliabadi

et al. 2021

Preprint

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“…Eyvazzadeh-Keihan and his group [121] designed and synthesized a novel and innovative nano-composite from functionalization of GO nanosheets with creatine (CR) and subsequently, Fe 3 O 4 NPs got intercalated in amine-functionalized GO nanosheets through in situ method. Further, this GO/CR-Fe 3 O 4 nano-composites were introduced as catalytic system for the condensation of varied aldehydes, dimedone and NH 4 OAc in EtOH at 70°C to provide corresponding phenyl(tetramethyl) acridinediones in excellent yields.…”

Section: Nano-catalyzed Synthesismentioning

confidence: 99%

Acridine‐1,8‐diones: Synthesis and Biological Applications

Sahiba¹,

Sethiya²,

Soni³

et al. 2021

ChemistrySelect

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The unpretentious features of acridine‐1,8‐diones viz. presence of N‐heteroatom, electronic behavior, acridine ring skeleton and wide possibilities of diversified substitution, bichromophoric structure and interaction ability with various proteins, make them an interesting scaffold of heterocyclic, medicinal and industrial chemistry. A tremendous development in the field of acridinediones in terms of synthetic strategies, bioactivity, industrial and other applicability has been explored in past four decades. In this perspective, an overview has been given on the state‐of‐art discoveries for the synthesis and biological applications of acridine‐1,8‐diones from 1980 to 2020. The study highlighted the history, chemistry and properties of these derivatives and provided deep insights into the synthetic protocols using various catalysts and techniques like nano‐catalyst, ionic‐liquids, microwave, ultrasound etc. under varied conditions along with biological activity against many lethal diseases. Finally, the respective prospects and limitations to these systems have been addressed. Furthermore, attempts have been done to bring many outstanding researches together and express the significance of acridine‐1,8‐diones through several aspects. We hope that the article shall deliver an impetus to explore further the synthetic values and mechanistic puzzles of acridinedione moiety and to design more promising hybrid multi‐targeted drugs and other industrial composites for the goodness of humanity

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“…8,9 For instance, the functionalization of GO with magnetic nanoparticles changes it to a green and reusable catalyst for multicomponent reactions. 10,11 On the other hand, GO functionalization is a multifunctional platform to developing adsorption agents for the removal of different kinds of pollutants from aqueous solutions. 12 In the last decades, drug carriers have gathered great attention in cancer therapy and other branches of medicine towards enhancing the inuence of drugs on target cells and reducing the side effect of drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Magnetic graphene oxide–lignin nanobiocomposite: a novel, eco-friendly and stable nanostructure suitable for hyperthermia in cancer therapy

et al. 2022

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Highly facilitated synthesis of phenyl(tetramethyl)acridinedione pharmaceuticals by a magnetized nanoscale catalytic system, constructed of GO, Fe3O4 and creatine

Cited by 39 publications

References 45 publications

Graphene Oxide-Lignin/Silk Fibroin/ZnO Nanobiocomposite: A Novel Bioactive Scaffold With Antibacterial Activity

Graphene Oxide-Lignin/Silk Fibroin/ZnO Nanobiocomposite: A Novel Bioactive Scaffold With Antibacterial Activity

Acridine‐1,8‐diones: Synthesis and Biological Applications

Magnetic graphene oxide–lignin nanobiocomposite: a novel, eco-friendly and stable nanostructure suitable for hyperthermia in cancer therapy

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