Highly Flexible Multifunctional Biopaper Comprising Chitosan Reinforced by Ultralong Hydroxyapatite Nanowires

Abstract

Highly flexible multifunctional biopaper comprising ultralong hydroxyapatite nanowires and chitosan (UHANWs/CS), with high weight fractions of ultralong hydroxyapatite nanowires (UHANWs) up to 100 wt. %, is reported. The as-prepared UHANWs/CS composite biopaper has high flexibility and superior mechanical properties even when the weight fraction of UHANWs is as high as 90 wt. %. In contrast, the control samples consisting of hydroxyapatite nanorods and chitosan (HANRs/CS) with weight fractions of HANRs higher than 66.7 wt.% cannot be obtained in the form of the flexible membrane. The ultimate tensile strength and Young's modulus of the UHANWs/CS composite biopaper are about 3.2 times and 4.3 times those of the HANRs/CS membrane with the same weight fraction of HAP, respectively. In addition, the UHANWs/CS composite biopaper (90 wt. % UHANWs) can be used for color printing using a commercial ink-jet printer. The surface wettability, swelling ratio, and water vapor transmission rate of the UHANWs/CS composite biopaper are adjustable by changing the addition amount of UHANWs. In vitro experiments indicate that the UHANWs/CS composite biopaper has good degradability, high acellular bioactivity and high biocompatibility. The as-prepared UHANWs/CS composite biopaper is therefore promising for various biomedical applications such as wound dressing, bone-fracture fixation, and bone-defect repair.

Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

“…11,22,26 Recent reports indicate that the addition of one-dimensional HAP nanostructured materials such as HAP whiskers and nanowires can signicantly improve the mechanical properties and biological responses of the composite biomaterials. 11,18,22,27 More signicantly, the highly exible ultralong HAP nanowires (UHANWs) with lengths of several hundred micrometres were prepared by the calcium oleate precursor solvothermal method by this research group, [28][29][30] and exhibit a great potential in constructing different types of biomaterials with enhanced mechanical properties and improved biological responses. 18,27,31 In addition, the morphology of the UHANWs is similar to that of mineralized collagen brils in the natural bone.…”

“…11,18,22,27 More signicantly, the highly exible ultralong HAP nanowires (UHANWs) with lengths of several hundred micrometres were prepared by the calcium oleate precursor solvothermal method by this research group, [28][29][30] and exhibit a great potential in constructing different types of biomaterials with enhanced mechanical properties and improved biological responses. 18,27,31 In addition, the morphology of the UHANWs is similar to that of mineralized collagen brils in the natural bone. Thus, the UHANWs offer a promising prospect for the construction of biomimetic HAP/Col porous nanocomposite with enhanced mechanical properties and biological responses.…”

Porous Nanocomposite Comprising Ultralong Hydroxyapatite Nanowires Decorated with Zinc‐Containing Nanoparticles and Chitosan: Synthesis and Application in Bone Defect Repair

“…[9,10] An ideal bone tissue engineereds caffold should possess aw ell-interconnected porouss tructure for cell infiltration and mass transportation, good mechanical properties to withstand mechanicalloading and support the newly formed bone, and controlled degradability for new bone tissue ingrowth, and bioactivity for improved osteogenic activity. [14][15][16][17] Hydroxyapatite (HAP,C a 10 (PO 4 ) 6 (OH) 2 )i sc hemically similar to the inorganic component of bone and teeth, the synthetic HAP materials have attracted much attention for biomedical applicationso wing to their excellent biocompatibility,g ood biodegradability,h igh osteoconductivity,a nd osteoinductivity. Importantly,t hese composite porouss caffolds can combinet he advantages of organic polymers and inorganic materials, which endows the scaffolds with great potential in bone-tissue engineering.…”

“…[14][15][16][17] Hydroxyapatite (HAP,C a 10 (PO 4 ) 6 (OH) 2 )i sc hemically similar to the inorganic component of bone and teeth, the synthetic HAP materials have attracted much attention for biomedical applicationso wing to their excellent biocompatibility,g ood biodegradability,h igh osteoconductivity,a nd osteoinductivity. [16,26,27] Combining the advantages of chitosan and HAP,v arious kinds of HAP/chitosanc omposite porouss caffolds wered eveloped and investigated for applications in bone tissue engineering. Chitosan, as the second most abundant natural polymer,i sadeacetylated derivative of chitin and a linear amino-polysaccharide which is structurally similar to gly-cosaminoglycan in the extracellular matrix of bone.…”

“…[16,26,27] Combining the advantages of chitosan and HAP,v arious kinds of HAP/chitosanc omposite porouss caffolds wered eveloped and investigated for applications in bone tissue engineering. [17] More importantly,t he highly flexible ultralong HAP nanowires (UHANWs) with lengths of several hundred micrometres were synthesized in our previous work, [32][33][34] and they exhibited ag reat potentiali nc onstructing varioust ypes of multifunctional materials with excellent mechanical properties, such as flexible fire-resistant ordered architectures, [35] highly flexible fire-resistant inorganic paper, [32] superhydrophobic and fire-resistantl ayered inorganic paper, [36] highly flexible multifunctional biopaper, [16,17] etc.T hus, the UHANWs are an ideal materialf or constructing biomimetic composite porous scaffoldsw ith enhanced mechanical properties and biological responses. [29][30][31] In this respect, 1D HAP nanostructures such as HAP whiskersa nd nanowires have obvious advantages in enhancing the mechanical properties of their composite scaffolds as compared with HAP nanorods.…”