Highly hydrophilic and antibiofouling surface of zwitterionic polymer immobilized on polydimethylsiloxane by initiator-free atmospheric plasma-induced polymerization

Chen, Jung-San; Ting, Yi-Shao; Tsou, Hui-Ming; Liu, Tingyu

doi:10.1016/j.surfcoat.2018.03.078

Cited by 36 publications

(17 citation statements)

References 25 publications

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“…This polymer is highly hydrophilic due to the phospholipid polar tail in the MPC molecular structure. Moreover, the inhibitory effect on the adhesion of cells, platelets, enzymes, and proteins in the blood can also reduce the chances of the organism recognizing the material as a foreign object, and increases the biocompatibility of the material [33,34]. Therefore, the hydrophilic bionic structure was imitated to exhibit the same liquid transport capability as the Nepenthes peristome in this study.…”

Section: Introductionmentioning

confidence: 97%

Replica of Bionic Nepenthes Peristome-like and Anti-Fouling Structures for Self-Driving Water and Raman-Enhancing Detection

Lin

Syu

et al. 2022

Polymers

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The flexible, anti-fouling, and bionic surface-enhanced Raman scattering (SERS) biochip, which has a Nepenthes peristome-like structure, was fabricated by photolithography, replicated technology, and thermal evaporation. The pattern of the bionic Nepenthes peristome-like structure was fabricated by two layers of photolithography with SU-8 photoresist. The bionic structure was then replicated by polydimethylsiloxane (PDMS) and grafting the zwitterion polymers (2-methacryloyloxyethyl phosphorylcholine, MPC) by atmospheric plasma polymerization (PDMS-PMPC). The phospholipid monomer of MPC immobilization plays an important role; it can not only improve hydrophilicity, anti-fouling and anti-bacterial properties, and biocompatibility, but it also allows for self-driving and unidirectional water delivery. Ag nanofilms (5 nm) were deposited on a PDMS (PDMS-Ag) substrate by thermal evaporation for SERS detection. Characterizations of the bionic SERS chips were measured by a scanning electron microscope (SEM), optical microscope (OM), X-ray photoelectron spectrometer (XPS), Fourier-transform infrared spectroscopy (FTIR), and contact angle (CA) testing. The results show that the superior anti-fouling capability of proteins and bacteria (E. coli) was found on the PDMS-PMPC substrate. Furthermore, the one-way liquid transfer capability of the bionic SERS chip was successfully demonstrated, which provides for the ability to separate samples during the flow channel, and which was detected by Raman spectroscopy. The SERS intensity (adenine, 10−4 M) of PDMS-Ag with a bionic structure is ~4 times higher than PDMS-Ag without a bionic structure, due to the multi-reflection of the 3D bionic structure. The high-sensitivity bionic SERS substrate, with its self-driving water capability, has potential for biomolecule separation and detection.

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Section: Introductionmentioning

confidence: 97%

Replica of Bionic Nepenthes Peristome-like and Anti-Fouling Structures for Self-Driving Water and Raman-Enhancing Detection

Lin

Syu

et al. 2022

Polymers

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“…Likewise, Shen et al [ 32 ] developed contact lenses with a surface modified with copolymers poly(3-trimethoxysilyl-propyl-methacrylate)-block-poly(2-methacryloyloxyethyl phosphorylcholine) (PMPS- b -PMPC), which showed significant surface-wettability improvement, protein adsorption resistance, and superior antibacterial adhesion properties. Additionally, some zwitterionic compounds, such as sulfobetaine methacrylate (SBMA), carboxymethyl betaine (CMB), etc., were used as comonomers and incorporated into the contact lens hydrogel matrix to improve anti-biofouling properties [ 33 , 34 , 35 ]. Herein, we prepared PSBMA nanogels by a convenient reflux-precipitation polymerization method [ 36 ], and the anti-inflammatory drug levofloxacin (LEV) was then incorporated into nanogels via hydrophobic and intermolecular interactions.…”

Section: Introductionmentioning

confidence: 99%

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Wang

Zhang

et al. 2021

Nanomaterials

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Therapeutic ophthalmic contact lenses with prolonged drug release and improved bioavailability have been developed to circumvent tedious eye drop instillation. In this work, zwitterionic nanogels based on poly(sulfobetaine methacrylate) (PSBMA) were easily fabricated by one-step reflux-precipitation polymerization, with the advantages of being surfactant-free and morphology controlled. Then, the ophthalmic drug levofloxacin (LEV) was encapsulated into the nanogels. A set of contact lenses with varied nanogel-loading content was fabricated by the cast molding method, with the drug-loaded nanogels dispersed in pre-monomer solutions composed of 2-hydroxyethyl methacrylate (HEMA) and N-vinyl-2-pyrrolidone (NVP). The structure, surface morphology, water contact angle (WCA), equilibrium water content (EWC), transmittance, and mechanical properties of the contact lenses were subsequently investigated, and in vitro drug release and biocompatibility were further evaluated. As a result, the optimized contact lens with nanogel-loading content of 8 wt% could sustainably deliver LEV for ten days, with critical lens properties within the range of recommended values for commercial contact lenses. Moreover, cell viability assays revealed that the prepared contact lenses were cytocompatible, suggesting their significant potential as an alternative to traditional eye drops or ointment formulations for long-term oculopathy treatment.

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“…To overcome this problem, most hydrogel silicone lenses need to be modified to reduce the hydrophobic nature of the silicon components, as well as decrease the protein deposition on the surface of the lens. To improve the wettability of the hydrogel silicon lenses a few methods such as plasma modifications and copolymerization have been developed (Chen et al 2018). To enhance wettability and address natural hydrophobicity of the silicone, methacrylic acid is added.…”

Section: Introductionmentioning

confidence: 99%

Reduction in protein absorption on ophthalmic lenses by PEGDA bulk modification of silicone acrylate-based formulation

et al. 2019

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The absorption of protein and formation of biofilms on the surface of ophthalmic lenses is one of the factors that destroy their useful performance by causing severe visual impairment, inflammation, dryness and ultimate eye discomfort. Therefore, eye lenses need to be resilient to protein absorption, which is one of the opacity factors in minimizing protein absorption on the lenses. The purpose of this study was to investigate and reduce sediment biotransformation on the surface of the semi-hardened lens based on acrylate by bulk-free radical polymerization method. In this respect, the effect of poly(ethylene glycol) diacrylate (PEGDA) with two different molecular weights of 200 and 600 g/mol on the surface roughness, protein absorption, and hydrophilicity of the lenses were studied. The surface hardness of the lenses, on shore D scale, was measured using a durometer hardness test. The presence of higher molecular weight of PEGDA hydrophilic polymeric monomers reduced the hardness of the lenses. The effect of introducing PEGDA, with two molecular weights, into lens fabrication formulations was studied with respect to their water content parameters and hydrophilicity. The presence of a crosslinker such as poly(ethylene glycol) diacrylates, at two different molecular weights, increased the water content and hydrophilicity of the produced lenses. Surface roughness is associated with the formation of bio-film and accumulation of microorganisms on the surface. Due to the roughness of the lens surface developed in this research, the lenses containing PEGDA 600 exhibited less roughness compared to that of PEGDA 200, which could also affect the absorption of protein. Therefore, according to the results of protein absorption test, the PEGDA 600 lenses showed lower protein absorption, which could be due to their high degree of water absorption and hydrophilicity.

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Highly hydrophilic and antibiofouling surface of zwitterionic polymer immobilized on polydimethylsiloxane by initiator-free atmospheric plasma-induced polymerization

Cited by 36 publications

References 25 publications

Replica of Bionic Nepenthes Peristome-like and Anti-Fouling Structures for Self-Driving Water and Raman-Enhancing Detection

Replica of Bionic Nepenthes Peristome-like and Anti-Fouling Structures for Self-Driving Water and Raman-Enhancing Detection

Novel Contact Lenses Embedded with Drug-Loaded Zwitterionic Nanogels for Extended Ophthalmic Drug Delivery

Reduction in protein absorption on ophthalmic lenses by PEGDA bulk modification of silicone acrylate-based formulation

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