Highly porous bioresorbable scaffolds with controlled release of bioactive agents for tissue-regeneration applications

Grinberg, Orly; Binderman, Itzhak; Bahar, Hila; Zilberman, Meital

doi:10.1016/j.actbio.2009.10.047

Cited by 23 publications

(10 citation statements)

References 15 publications

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“…After freeze drying, porous materials loaded with protein were produced and used as the matrix for the controlled delivery of protein. 90,91 Cameron et al 92 prepared porous PLGA and PCL materials by freeze drying water-in-oil emulsions using Span 80 as a surfactant.…”

Section: Emulsionsmentioning

confidence: 99%

Controlled freezing and freeze drying: a versatile route for porous and micro-/nano-structured materials

Qian

Zhang

2010

J. Chem. Technol. Biotechnol.

425

282

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Freeze drying is a process whereby solutions are frozen in a cold bath and then the frozen solvents are removed via sublimation under vacuum, leading to formation of porous structures. Pore size, pore volume and pore morphology are dependent on variables such as freeze temperature, solution concentration, nature of solvent and solute, and the control of the freeze direction. Aqueous solutions, organic solutions, colloidal suspensions, and supercritical CO 2 solutions have been investigated to produce a wide range of porous and particulate structures. Emulsions have recently been employed in the freeze drying process, which can exert a systematic control on pore morphology and pore volume and can also lead to the preparation of organic micro-and nano-particles. Spray freezing and directional freezing have been developed to form porous particles and aligned porous materials. This review describes the principles, latest progress and applications of materials prepared by controlled freezing and freeze drying. First of all the basics of freeze drying and the theory of freezing are discussed. Then the materials fabricated by controlled freezing and freeze drying are reviewed based on their morphologies: porous structures, microwires and nanowires, and microparticles and nanoparticles. The review concludes with new developments in this area and a brief look into the future.

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Section: Emulsionsmentioning

confidence: 99%

Controlled freezing and freeze drying: a versatile route for porous and micro-/nano-structured materials

Qian

Zhang

2010

J. Chem. Technol. Biotechnol.

425

282

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“…Multiple poly(α-esters) have been used extensively in bone tissue engineering and for cancer models including poly(caprolactone) (PCL) [45–47], PLA [48, 49], and poly(lactic-co-glycolic acid) (PLGA) [50, 51]. These are bio-compatible and biodegradable polymers that have other biomaterial applications such as drug delivery.…”

Section: D Bone Modelsmentioning

confidence: 99%

“…Traditional methods to fabricate porous TECs from natural or synthetic polymers include gas foaming [62, 63], particulate leaching [52, 64, 65], or freeze-drying [50, 66]. While these methods are effective in creating porous scaffolds, they lack the control necessary to create specific architectures.…”

Section: D Bone Modelsmentioning

confidence: 99%

Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments

Kwakwa

Vanderburgh

Guelcher

et al. 2017

Curr Osteoporos Rep

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Purpose of Review Bone is a structurally unique microenvironment that presents many challenges for the development of 3D models for studying bone physiology and diseases, including cancer. As researchers continue to investigate the interactions within the bone microenvironment, the development of 3D models of bone has become critical. Recent Findings 3D models have been developed that replicate some properties of bone, but have not fully reproduced the complex structural and cellular composition of the bone microenvironment. This review will discuss 3D models including polyurethane, silk, and collagen scaffolds that have been developed to study tumor-induced bone disease. In addition, we discuss 3D printing techniques used to better replicate the structure of bone. Summary 3D models that better replicate the bone microenvironment will help researchers better understand the dynamic interactions between tumors and the bone microenvironment, ultimately leading to better models for testing therapeutics and predicting patient outcomes.

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“…These are termed “themodynamic parameters,” due to their strong effect on the microstructure through the emulsion's stability, as will be explained in details and examples below. The formulation parameters were found to be more important than the process parameters in determining the microstructure 67 - 72 …”

Section: Drug-eluting Porous Structures Based On Freeze-dried Invertementioning

confidence: 99%

“…= 83 KDa) in the organic solution, 1% w/w HRP in the aqueous medium (relative to the polymer load), and an organic to aqueous (O:A) phase ratio of 4:1 v/v was used as the reference formulation. Most films exhibited a HRP release profile of an initial burst release accompanied by a decreased release rate with time 67 . A dual pore size population is characteristic of most films, with large 12–18 μm pores and small 1.5–7 μm pores, and porosity in the range of 76–92%.…”

Section: Porous Structures With Protein Controlled Releasementioning

confidence: 99%

Highly porous drug-eluting structures

et al. 2012

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For many biomedical applications, there is need for porous implant materials. The current article focuses on a method for preparation of drug-eluting porous structures for various biomedical applications, based on freeze drying of inverted emulsions. This fabrication process enables the incorporation of any drug, to obtain an “active implant” that releases drugs to the surrounding tissue in a controlled desired manner. Examples for porous implants based on this technique are antibiotic-eluting mesh/matrix structures used for wound healing applications, antiproliferative drug-eluting composite fibers for stent applications and local cancer treatment, and protein-eluting films for tissue regeneration applications. In the current review we focus on these systems. We show that the release profiles of both types of drugs, water-soluble and water-insoluble, are affected by the emulsion's formulation parameters. The former's release profile is affected mainly through the emulsion stability and the resulting porous microstructure, whereas the latter's release mechanism occurs via water uptake and degradation of the host polymer. Hence, appropriate selection of the formulation parameters enables to obtain desired controllable release profile of any bioactive agent, water-soluble or water-insoluble, and also fit its physical properties to the application.

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Highly porous bioresorbable scaffolds with controlled release of bioactive agents for tissue-regeneration applications

Cited by 23 publications

References 15 publications

Controlled freezing and freeze drying: a versatile route for porous and micro-/nano-structured materials

Controlled freezing and freeze drying: a versatile route for porous and micro-/nano-structured materials

Engineering 3D Models of Tumors and Bone to Understand Tumor-Induced Bone Disease and Improve Treatments

Highly porous drug-eluting structures

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