Highly Protein Repellent and Antiadhesive Polysaccharide Biomaterial Coating for Urinary Catheter Applications

Mohan, Tamilselvan; Čas, Alja; Bračič, Matej; Plohl, Olivija; Vesel, Alenka; Rupnik, Maja; Zemljič, Lidija Fras; Rebol, Janez

doi:10.1021/acsbiomaterials.9b01288

Cited by 36 publications

(38 citation statements)

References 44 publications

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“…Furthermore, the BSA adsorption onto NPcat turns out to be significantly higher, even compared to polydimethylsiloxane and polyethyleneimine (7 and 9 mg m −2 , respectively), which are commonly used layers for immunoactive reagent immobilization. [ 47 ] Comparison to these literature values also shows that although cationic starch has a lower degree of substitution than NPcat (0.05 vs 0.17), it is a very good reference as cationic polymer coating. The studied cationic starch had a similar polymer adsorption than that of higher charged cationic polymers, such as cationic cellulose, chitosan, and polyethyleneimine.…”

Section: Resultsmentioning

confidence: 84%

“…The studied cationic starch had a similar polymer adsorption than that of higher charged cationic polymers, such as cationic cellulose, chitosan, and polyethyleneimine. [28,31,33,45,47] The BSA affinity to the NPcat nanogel layer was remarkably enhanced. Usually, the repulsive double layer forces of individual, negatively charged BSA [35] limit protein adsorption, Figure 2.…”

Section: (4 Of 9)mentioning

confidence: 99%

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Self‐Assembly of Soft Cellulose Nanospheres into Colloidal Gel Layers with Enhanced Protein Adsorption Capability for Next‐Generation Immunoassays

Solin

Beaumont

Rosenfeldt

et al. 2020

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soft, core-shell cellulosic nanoparticles, for instance, to alter surface activity toward proteins, [4,5] remains largely untapped. Nanoparticles are generally synthesized by grafting soft polymeric structures onto rigid, rod-like nanocrystals, i.e., becoming hard-core/soft-shell nanoparticles. [6,7] This approach is rather time-consuming, especially if compared to cellulose II hydrogels. [8-10] Expanding on the latter, cellulose II nanospheres have been recently introduced through a facile and "green" avenue. [11,12] They consist of spherical nanocrystals [13-15] interconnected within a fibrillar network. [8-10,16] By installing repulsive charges onto the surface of cellulose II hydrogels, it is possible to develop functional cellulose II nanospheres with an intrinsic soft and amorphous shell. [11,12] This new class of cellulose colloids features the rheological and electrophoretic properties typical of soft particles as well as intraparticle and pH-responsive swelling behavior. The shells of the soft particles are anionic and can deform and interpenetrate [17-19] into a jammed colloidal nanogel. [12] Among the latter, classical supramolecular nanogels are defined as swollen nanosized networks of polymer chains [20] and are already used, for example, to control protein interactions. [21-24] Controlling these interactions is crucial in Soft cationic core/shell cellulose nanospheres can deform and interpenetrate allowing their self-assembly into densely packed colloidal nanogel layers. Taking advantage of their water-swelling capacity and molecular accessibility, the nanogels are proposed as a new and promising type of coating material to immobilize bioactive molecules on thin films and paper. The specific and nonspecific interactions between the cellulosic nanogel and human immunoglobulin G as well as bovine serum albumin (BSA) are investigated. Confocal microscopy, electroacoustic microgravimetry, and surface plasmon resonance are used to access information about the adsorption behavior and viscoelastic properties of self-assembled nanogels. A significant BSA adsorption capacity on nanogel layers (17 mg m −2) is measured, 300% higher compared to typical polymer coatings. This high protein affinity further confirms the promise of the introduced colloidal gel layer, in increasing sensitivity and advancing a new generation of substrates for a variety of applications, including immunoassays, as demonstrated in this work.

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Section: Resultsmentioning

confidence: 84%

Section: (4 Of 9)mentioning

confidence: 99%

Self‐Assembly of Soft Cellulose Nanospheres into Colloidal Gel Layers with Enhanced Protein Adsorption Capability for Next‐Generation Immunoassays

Solin

Beaumont

Rosenfeldt

et al. 2020

Small

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“…Biomaterials derived from natural products have been of interest in recent decades due to their abundance, low cost, biocompatibility and tunable morphological and physical properties [1][2][3][4][5]. These materials have been broadly used for the development of membranes and fibers for liquid and gas separation [6] and sensing [7,8], fabrication of tissue engineering scaffolds for neural [9] or bone regeneration [10] and for the fabrication of nanostructures for drug delivery [11].…”

Section: Introductionmentioning

confidence: 99%

Protein and Polysaccharide-Based Fiber Materials Generated from Ionic Liquids: A Review

et al. 2020

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Natural biomacromolecules such as structural proteins and polysaccharides are composed of the basic building blocks of life: amino acids and carbohydrates. Understanding their molecular structure, self-assembly and interaction in solvents such as ionic liquids (ILs) is critical for unleashing a flora of new materials, revolutionizing the way we fabricate multi-structural and multi-functional systems with tunable physicochemical properties. Ionic liquids are superior to organic solvents because they do not produce unwanted by-products and are considered green substitutes because of their reusability. In addition, they will significantly improve the miscibility of biopolymers with other materials while maintaining the mechanical properties of the biopolymer in the final product. Understanding and controlling the physicochemical properties of biopolymers in ionic liquids matrices will be crucial for progress leading to the ability to fabricate robust multi-level structural 1D fiber materials. It will also help to predict the relationship between fiber conformation and protein secondary structures or carbohydrate crystallinity, thus creating potential applications for cell growth signaling, ionic conductivity, liquid diffusion and thermal conductivity, and several applications in biomedicine and environmental science. This will also enable the regeneration of biopolymer composite fiber materials with useful functionalities and customizable options critical for additive manufacturing. The specific capabilities of these fiber materials have been shown to vary based on their fabrication methods including electrospinning and post-treatments. This review serves to provide basic knowledge of these commonly utilized protein and polysaccharide biopolymers and their fiber fabrication methods from various ionic liquids, as well as the effect of post-treatments on these fiber materials and their applications in biomedical and pharmaceutical research, wound healing, environmental filters and sustainable and green chemistry research.

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“…The other is to modify the surface of the original material by coating. This one has relatively broad adaptability, and is easy to operate with low prices 12–17 . Polyurethane is a popular polymer material on various occasions for its unique structural designability properties and group activity.…”

Section: Introductionmentioning

confidence: 99%

“…This one has relatively broad adaptability, and is easy to operate with low prices. [12][13][14][15][16][17] Polyurethane is a popular polymer material on various occasions for its unique structural designability properties and group activity. Especially in the medical field, it is widely used in medical devices such as dressings, tubing, antibacterial membranes, catheters, artificial hearts, and blood contact materials.…”

Section: Introductionmentioning

confidence: 99%

A novel cationic waterborne polyurethane coating modified by chitosan biguanide hydrochloride with application potential in medical catheters

Liu

Zou

Wang

et al. 2020

J of Applied Polymer Sci

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This study reported the synthesis and properties of a new cationic waterborne polyurethane coating. In this work, a chitosan derivative, chitosan biguanide hydrochloride (CSGH), was synthesized, which was used as a blocking agent and cross‐linking agent to participate in the copolymerization of waterborne polyurethane (WPU) and a bioactive ingredient to enhance the biocompatibility of the coating. FTIR results demonstrated the reaction of CSGH with WPU. Moreover, the particle size distribution of the emulsion and SEM results showed that CSGH and WPU were well integrated. Benefiting from the formation of the cross‐linking network, the thermodynamic properties of the coating were significantly improved. Furthermore, due to adding 3 wt% CSGH, the water contact angle of the coating surface decreased from 97.01° to 69.30°, indicating that the coating surface changed from hydrophobic to hydrophilic. And a specific resistance to Staphylococcus aureus and Escherichia coli was exhibited without cytotoxicity, the resistance rates could reach 85% and 91% respectively. It is highlighted that this WPU‐CSGH coating has great application potential in the field of medical interventional catheters.

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Highly Protein Repellent and Antiadhesive Polysaccharide Biomaterial Coating for Urinary Catheter Applications

Cited by 36 publications

References 44 publications

Self‐Assembly of Soft Cellulose Nanospheres into Colloidal Gel Layers with Enhanced Protein Adsorption Capability for Next‐Generation Immunoassays

Self‐Assembly of Soft Cellulose Nanospheres into Colloidal Gel Layers with Enhanced Protein Adsorption Capability for Next‐Generation Immunoassays

Protein and Polysaccharide-Based Fiber Materials Generated from Ionic Liquids: A Review

A novel cationic waterborne polyurethane coating modified by chitosan biguanide hydrochloride with application potential in medical catheters

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