Engineering
functional biomaterials surfaces that resist biofilm
formation triggered by unspecific protein adsorption is a key challenge,
and these biosurfaces hold a huge potential in implant-associated
infection. Herein, we report a water-based facile approach to install
carboxylated-hyaluronic acid and sulfated-fucoidan on cationically
tethered polydimethylsiloxane (PDMS) implant. We showed that these
hydrophilic, charged, polysaccharide-based biosurfaces/biocoatings
provide long-term stability, no adsorption of proteins (albumin and
fibrinogen), similar to zwitterionic polymers, and enhanced resistance
to plasma deposition and growth of Staphylococcus aureus pathogen. These findings shall pave the way in developing novel
biocoatings, thereby broadening the applicability of PDMS-based implants
in complex biological applications.
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