Highly purified eicosapentaenoic acid prevents the progression of hepatic steatosis by repressing monounsaturated fatty acid synthesis in high-fat/high-sucrose diet-fed mice

Metabolic and immunomodulatory effects of n-3 fatty acids are different in mesenteric and epididymal adipose tissue of diet-induced obese mice

“…This may be partly a result of the observed reduced hepatic TAG concentrations and lower nonfasting plasma NEFA (29,30,42) in HF/n-3 mice, consistent with the downregulation of the lipogenic genes Scd-1 and Acac␣ (15,28) and the upregulation of Acox1, which initiates peroxisomal ␤-oxidation, in the liver (13,56). The observed unaltered hepatic Cpt1a expression indicates increased activity in peroxisomal ␤-oxidation and unchanged mitochondrial ␤-oxidation (15).…”

“…For long-chain n-3 (LC-n-3) PUFA, positive effects on insulin secretion are described, although effects on glucose tolerance are not consistent (14). Furthermore, lipid-lowering effects in high-fat diet-induced hypertriglyceridemia have been reported in various intervention studies (29,30).…”

Docosahexaenoic Acid Content in Plasma Phospholipids and Desaturase Indices in Obese Children

“…A study in DHA-fed spontaneously hypertensive rats demonstrated that SCD activity was decreased by 53% and was accompanied by an increase in palmitic acid and a reduction in palmitoleic acid content in hepatic microsomes 30) . In addition, in high-fat/high-sucrose diet-fed mice, oral administration of highly purified EPA ethyl ester decreases hepatic MUFAs accumulation by SCD-1 31) . Our results in obese children are compatible with these animal studies; therefore, we suggest that dietary DHA may suppress SCD, and then protect against the development of obesity.…”

Dietary Starfish Oil Prevents Hepatic Steatosis and Hyperlipidemia in C57BL/6N Mice Fed High-fat Diet

“…SCD-1, a downstream target of SREBP, is known to catalyze delta-9 desaturation of SFA such as C16:0 and C18:0 mainly in the liver and adipose tissue, and recent studies have shown a relationship between the high expression of SCD-1 and development of obesity and metabolic syndrome 38,39 . An earlier study demonstrated that suppression of SCD-1 by EPA prevents hepatic steatosis in diet-induced obese mice 40 . Based on these results, the decrease in hepatic TG in mice fed the SO diets is likely to be a result of modulation of SREBP expression and its target genes including SCD-1 in the liver.…”