Highly selective biotransformation of (+)-(1S)- and (−)-(1R)-camphorquinone byAspergillus wentii

High-value-added compounds, such as monoterpenoids, are an important industrial targets because they are an essential group of compounds for pharmaceutical and industrial applications. Meanwhile, the depletion of natural resources and climate change demands sustainable production methods. In recent years, biocatalysis, which allows microbial bioproduction by regio- and stereo-selective reaction under mild conditions, has been attracted researchers' attention as a possible alternative to conventional methods. In this mini-review, we focus on the identification of biotransformation pathways in the non-model microorganism Acinetobacter sp. Tol 5 using geraniol, a representative monoterpenoid, and on the construction of an unconventional bioproduction method for high-value-added monoterpenoid (E)-geranic acid, which has great potential for industrial applications. This method offers a more environmentally friendly approach and insights contribute to optimizing biotransformation and bioproduction strategies for high-value-added compounds.

show abstract

Fungal Biotransformation: An Efficient Approach for Stereoselective Chemical Reactions

Santos

Neto

Júnior

et al. 2020

COC

View full text Add to dashboard Cite

Abstract:: There is great interest in developing chemical technologies to achieve regioselective and stereoselective reactions since only one enantiomer is required for producing the chiral leads for drug development. These selective reactions are dif-ficultly provided by traditional chemical synthetic methods, even under expensive catalysts and long reaction times. Fila-mentous fungi are efficient biocatalysts capable of catalyzing a wide variety of reactions with significant contributions to the development of clean and selective processes. Although some enzymes have already been employed in isolated forms or as crude protein extracts as catalysts for conducting selective reactions, the use of whole-cell provides advantages regarding cofactor regenerations. It is also possible to carry out conversions at chemically unreactive positions and to perform racemic resolution through microbial transformation. The current literature contains several reports on the biotransformation of dif-ferent compounds by fungi, which generated chemical analogs with high selectivity, using mild and eco-friendly conditions. Prompted by the enormous pharmacological interest in the development of stereoselective chemical technologies, this re-view covers the biotransformations catalyzed by fungi that yielded chiral products with enantiomeric excesses published over the period 2010-2020. This work highlights new approaches for the achievement of a variety of bioactive chiral build-ing blocks, which can be a good starting point for the synthesis of new compounds combining biotransformation and syn-thetic organic chemistry.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Highly selective biotransformation of (+)-(1S)- and (−)-(1R)-camphorquinone byAspergillus wentii

Cited by 3 publications

References 14 publications

Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties

Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties

Development of biocatalysts for high-value-added compounds

Fungal Biotransformation: An Efficient Approach for Stereoselective Chemical Reactions

Contact Info

Product

Resources

About