Highly selective determination of uric acid in the presence of ascorbic acid at glassy carbon electrodes modified with carbon nanotubes dispersed in polylysine

Rodrı́guez, Marcela C.; Sandoval, José; Galicia, Laura; Gutiérrez, Silvia; Rivas, Gustavo A.

doi:10.1016/j.snb.2008.05.035

Cited by 62 publications

(36 citation statements)

References 59 publications

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“…This modified electrode displayed strong electrocatalytic activity towards oxidation of dopamine, AA and UA with concurrent reduction of overpotential. A highly selective sensor for UA based on glassy carbon electrodes onto which was cast a dispersion of carbon nanotubes in an aqueous polylysine solution was reported where the limit of detection for UA was 1.7 10 À5 mol L À1 using cyclic voltammetry and 2.2 10 À6 mol L À1 using differential pulse voltammetry in solutions containing 10 À3 mol L À1 ascorbate [111]. Along with the studies on carbon nanotubes and their wide range of applications, other carbon-based materials, such as the development of ordered mesoporous carbons, are being increasingly studied owing to their favourable properties, such as uniform and tailored pore structures, high specific surface areas, large pore volumes and chemical inertness [112].…”

Section: Nanoparticle/conducting Nanomaterials Modified Electrodesmentioning

confidence: 99%

Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

et al. 2011

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The present review has sought to explore the technological advances that have been made in recent years towards the selective analysis of uric acid and critically evaluate how they could, in fact, be exploited as a basis for a multi analyte sensor incorporating uric acid detection. Numerous strategies have evolved in recent years but these have invariably focused on the manufacture and response characterization of discrete sensors. Various methods of obtaining selective detection such as use of uricase enzymes, nanoparticles, carbon nanotubes, polymers, conducting polymers and MIPs are also discussed along with the clinical relevance of UA determination.

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Section: Nanoparticle/conducting Nanomaterials Modified Electrodesmentioning

confidence: 99%

Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

et al. 2011

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“…In the case of SWCNTs-β-CD/GCE, however, two well-distinguished anodic peaks at potentials of 8 and 379 mV were observed, corresponding to the oxidation of AA and UA, respectively, (curve B). Worth noticing is that the anodic peak potential difference between AA and UA is approximately 371 mV, which is much bigger than early reported methods [41][42][43]. This suggested the electron transfer on the modified GCE was facilitated.…”

Section: Electrochemical Sensor Of Aa and Ua By Swcnts-β-cd Modified Gcementioning

confidence: 80%

<i>β</i>-cyclodextrin Covalently Functionalized Single-Walled Carbon Nanotubes: Synthesis, Characterization and a Sensitive Biosensor Platform

Gao¹,

Cao²,

Song³

et al. 2011

JBNB

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In this study, we presented the preparation of β-cyclodextrin (β-CD) covalently functionalized single-walled carbon nanotubes (SWCNTs) and its application in modifying the solid glass carbon electrode (GCE). Cyclic voltammetry (CV) method was employed to evaluate the performance of the modified GCE. Solubility experiment indicated the conjugation of SWCNTs and β-CD, SWCNTs-β-CD with 8 wt% β-CD content could be well dispersed in water. High-resolution transmission electron microscopy (HRTEM) demonstrated that the aggregated SWCNTs bundle were effectively exfoliated to small bundle, even individual tube. The β-CD component was grafted on the side walls as well as tips of SWCNTs, and the grafted β-CD component was not uniformly coated on the surface of SWCNTs. The CV measurements indicated the performance of the GCE modified by SWCNTs-β-CD was better than that of the GCE modified by the hybrid of SWCNTs

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“…The sensor simultaneously detects UA and DA in the presence of elevated AA concentrations. MWCNT-polylysine (Plys) modified GCE can also be used for sensing UA (Rodríguez et al, 2008) as it decreases the overvoltages for AA oxidation (440 mV), which effects the distinction of the oxidation of AA and UA.…”

Section: Neurotransmitters/neurochemicalsmentioning

confidence: 99%

Advances in carbon nanotube based electrochemical sensors for bioanalytical applications

Vashist

Zheng

Al‐Rubeaan

et al. 2011

Biotechnology Advances

407

218

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Electrochemical (EC) sensing approaches have exploited the use of carbon nanotubes (CNTs) as electrode materials owing to their unique structures and properties to provide strong electrocatalytic activity with minimal surface fouling. Nanofabrication and device integration technologies have emerged along with significant advances in the synthesis, purification, conjugation and biofunctionalization of CNTs. Such combined efforts have contributed towards the rapid development of CNT-based sensors for a plethora of important analytes with improved detection sensitivity and selectivity. The use of CNTs opens an opportunity for the direct electron transfer between the enzyme and the active electrode area. Of particular interest are also excellent electrocatalytic activities of CNTs on the redox reaction of hydrogen peroxide and nicotinamide adenine dinucleotide, two major by-products of enzymatic reactions. This excellent electrocatalysis holds a promising future for the simple design and implementation of on-site biosensors for oxidases and dehydrogenases with enhanced selectivity. To date, the use of an anti-interference layer or an artificial electron mediator is critically needed to circumvent unwanted endogenous electroactive species. Such interfering species are effectively suppressed by using CNT based electrodes since the oxidation of NADH, thiols, hydrogen peroxide, etc. by CNTs can be performed at low potentials. Nevertheless, the major future challenges for the development of CNT-EC sensors include miniaturization, optimization and simplification of the procedure for fabricating CNT based electrodes with minimal non-specific binding, high sensitivity and rapid response followed by their extensive validation using "real world" samples. A high resistance to electrode fouling and selectivity are the two key pending issues for the application of CNT-based biosensors in clinical chemistry, food quality and control, waste water treatment and bioprocessing.

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Highly selective determination of uric acid in the presence of ascorbic acid at glassy carbon electrodes modified with carbon nanotubes dispersed in polylysine

Cited by 62 publications

References 59 publications

Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

<i>β</i>-cyclodextrin Covalently Functionalized Single-Walled Carbon Nanotubes: Synthesis, Characterization and a Sensitive Biosensor Platform

Advances in carbon nanotube based electrochemical sensors for bioanalytical applications

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Highly selective determination of uric acid in the presence of ascorbic acid at glassy carbon electrodes modified with carbon nanotubes dispersed in polylysine

Cited by 62 publications

References 59 publications

Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

Electrochemical Detection of Uric Acid in Mixed and Clinical Samples: A Review

&lt;i&gt;β&lt;/i&gt;-cyclodextrin Covalently Functionalized Single-Walled Carbon Nanotubes: Synthesis, Characterization and a Sensitive Biosensor Platform

Advances in carbon nanotube based electrochemical sensors for bioanalytical applications

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<i>β</i>-cyclodextrin Covalently Functionalized Single-Walled Carbon Nanotubes: Synthesis, Characterization and a Sensitive Biosensor Platform