Highly sensitive and rapid LC–ESI-MS/MS method for the simultaneous quantification of uroselective α1-blocker, alfuzosin and an antimuscarinic agent, solifenacin in human plasma

Mistri, Hiren N.; Jangid, Arvind G.; Pudage, Ashutosh; Rathod, Dhiraj M.; Shrivastav, Pranav S.

doi:10.1016/j.jchromb.2008.10.050

Cited by 40 publications

(30 citation statements)

References 22 publications

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“…A number of studies describing human systemiclevel and pharmacokinetics of solifenacin had been published [8][9][10][11][12][13]. However, no specific and sufficient details related to the IS used, sample extraction and preparation procedures and MS/MS detection set-up were given [9][10][11][12][13] to allow the reproduction of the used solifenacin analytical methods.…”

Section: Discussionmentioning

confidence: 99%

“…However, no specific and sufficient details related to the IS used, sample extraction and preparation procedures and MS/MS detection set-up were given [9][10][11][12][13] to allow the reproduction of the used solifenacin analytical methods. On the other hand, Mistri et al had some limitations in their pre-analytical protein precipitation step needed to extract solifenacin from its biological matrix [10]. This led to problems related to the analytical column blockage, ion source cleaning and matrix interferences.…”

Section: Discussionmentioning

confidence: 99%

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Quantitation of Solifenacin in Human Plasma using a Specific and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Technique

Ammari¹

2015

Trop. J. Pharm Res

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Purpose: The current work validated a high performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) bioassay method developed in-house for the quantitation of solifenacin in human plasma. Methods: Solifenacin was extracted from plasma by a liquid-liquid extraction (LLE) technique using tertbutyl methyl ether. The dry extract was then reconstituted with 200 μL of the mobile phase (acetonitrilewater (80:20, v/v)). Solifenacin-d5 was the internal standard (IS). Elution was carried out on a C18 column at a flow rate of 1 mL/min. The MS/MS employed turbo-ion spray ionization in

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Quantitation of Solifenacin in Human Plasma using a Specific and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Technique

Ammari¹

2015

Trop. J. Pharm Res

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“…Literature survey reveals that quantification of Solifenacin in human plasma (Macek et al 2010;Mistri et al 2008), rat plasma (Yanagihara et al 2007), pharmaceutical compounds (Krishna et al 2010;Desai et al 2012;Rami Reddy et al 2013;Desai et al 2011), and industrial waste streams (Ann-Marie et al 2011) were reported. These methods were reported by using liquid chromatographyelectrospray ionization-tandem mass spectrometry (LC-MS/ MS) (Macek et al 2010;Mistri et al 2008;Ann-Marie et al 2011), high-performance liquid chromatography (HPLC) (Yanagihara et al 2007;Krishna et al 2010;Desai et al 2012;Rami Reddy et al 2013), and HPTLC (Desai et al 2011).…”

Section: Introductionmentioning

confidence: 99%

“…These methods were reported by using liquid chromatographyelectrospray ionization-tandem mass spectrometry (LC-MS/ MS) (Macek et al 2010;Mistri et al 2008;Ann-Marie et al 2011), high-performance liquid chromatography (HPLC) (Yanagihara et al 2007;Krishna et al 2010;Desai et al 2012;Rami Reddy et al 2013), and HPTLC (Desai et al 2011). Among all, quantification of Solifenacin by LC-MS/MS in biological matrices (Macek et al 2010;Mistri et al 2008;Yanagihara et al 2007) was proved best results. Macek et al 2010 reported with the linearity range of 0.47 to 42 ng/mL and used PPT method for extraction of drug and internal standard (IS).…”

Section: Introductionmentioning

confidence: 99%

Bioanalytical method for quantification of Solifenacin in rat plasma by LC-MS/MS and its application to pharmacokinetic study

et al. 2014

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Background: Solifenacin succinate is a competitive muscarinic acetylcholine receptor antagonist used in the treatment of overactive bladder with or without urge incontinence. Methods: Liquid chromatography-tandem mass spectrometry method was used for quantification of Solifenacin (SF) in rat plasma. Solifenacin-d5 (SFD5) used as an internal standard. Chromatographic separation was performed Gemini-NX C18, 50 × 4. Conclusions: This method is successfully applied in the Pharmacokinetic study of rat plasma.

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“…1). Chromatographic techniques such as high performance liquid chromatography [5,6], stability indicating high performance liquid chromatography [7][8][9], stability indicating ultrafast liquid chromatography [10], semi-micro high performance liquid chromatography [11], liquid chromatography-tandem mass spectrometry [12,13], stability-indicating high performance thin layer chromatography [14,15] have been applied for the quantification of SFS in bulk, biological fluids and commercial formulations. Though the chromatographic methods are sensitive the instrumentations are burdensome and necessitate critical experimental conditions.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Spectrophotometric Methods for the Quantification of Solifenacin Succinate: Application to Tablet Dosage Forms

Seshamamba

Satyanarayana

Sekaran³

2013

ILCPA

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Four sensitive, precise and accurate spectrophotometric methods for the estimation of solifenacin succinate (SFS) have been developed. Method A describes the interaction of SFS with potassium permanganate in alkaline medium to give green colored manganate ion with absorption maxima at 610 nm. Methods B and C are based on the formation of ternary complexes of SFS with, copper (II)/eosin (method B) and ammonium molybdate/ammonium thiocyanate (method C), respectively which are extracted into chloroform and have absorption maxima at 545 nm (method B) and 465 nm (method C). Method D was based on the formation of yellow colored ion-pair complex between bromocresol green and SFS in dichloromethane medium with absorption maxima at 415 nm. Regression analysis of Beer's law plot showed good correlation in the concentration range of 5-50, 2.5-50, 10-100 and 2-20 μg/mL for methods A, B, C and D, respectively. Different variables affecting the reaction were studied and optimized. The proposed methods were applied successfully for the analysis of SFS in tablets dosage forms. No interference was observed from common pharmaceutical excipients.

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Highly sensitive and rapid LC–ESI-MS/MS method for the simultaneous quantification of uroselective α1-blocker, alfuzosin and an antimuscarinic agent, solifenacin in human plasma

Cited by 40 publications

References 22 publications

Quantitation of Solifenacin in Human Plasma using a Specific and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Technique

Quantitation of Solifenacin in Human Plasma using a Specific and Sensitive Liquid Chromatography-Tandem Mass Spectrometry Technique

Bioanalytical method for quantification of Solifenacin in rat plasma by LC-MS/MS and its application to pharmacokinetic study

Development and Validation of Spectrophotometric Methods for the Quantification of Solifenacin Succinate: Application to Tablet Dosage Forms

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