Highly-sensitive and reflective glucose sensor based on optical fiber surface plasmon resonance

Zheng, Wanlu; Han, Bo; Siyu, E; Sun, Yang; Li, Xuegang; Cai, Yong; Zhang, Yanan

doi:10.1016/j.microc.2020.105010

Cited by 71 publications

(27 citation statements)

References 30 publications

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“…The sensor can also distinguish biological binding events by detecting RI changes at the fiber’s surface, as previously proposed. ,− In this section, we prove the label-free detection of DNA hybridization using this sensor.…”

Section: Results and Discussionmentioning

confidence: 69%

In Situ Temperature-Compensated DNA Hybridization Detection Using a Dual-Channel Optical Fiber Sensor

Gong

Wang²,

Zhou

et al. 2021

Anal. Chem.

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A multifunction, high-sensitivity, and temperaturecompensated optical fiber DNA hybridization sensor combining surface plasmon resonance (SPR) and Mach−Zehnder interference (MZI) has been designed and implemented. We demonstrate, for the first time to our knowledge, the dual-parameter measurement of temperature and refractive index (RI) by simultaneously using SPR and MZI in a simple single-mode fiber (SMF)−no-core fiber (NCF)−SMF structure. The experimental results show RI sensitivities of 930 and 1899 nm/RIU and temperature sensitivities of 0.4 and −1.4 nm/°C for the MZI and SPR, respectively. We demonstrate a sensitivity matrix used to simultaneously detect both parameters, solving the problem of temperature interference of RI variation-based biosensors. In addition, the sensor can also distinguish biological binding events by detecting the localized RI changes at the fiber's surface. We realize label-free sensing of DNA hybridization detection by immobilizing probe DNA (pDNA) onto the fiber as the probe to capture complementary DNA (cDNA). The experimental results show that the sensor can qualitatively detect cDNA after temperature compensation, and the limit of detection (LOD) of the sensor reaches 80 nM. The proposed sensor has advantages of high sensitivity, real time, low cost, temperature compensation, and low detection limit and is suitable for in situ monitoring, high-precision sensing of DNA molecules, and other related fields, such as gene diagnosis, kinship judgment, environmental monitoring, and so on.

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Section: Results and Discussionmentioning

confidence: 69%

In Situ Temperature-Compensated DNA Hybridization Detection Using a Dual-Channel Optical Fiber Sensor

Gong

Wang²,

Zhou

et al. 2021

Anal. Chem.

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“…This sensing approach was studied in a detection range up to 10 mM, achieving a LOD of 322 μM and a sensitivity of 0.93 nm/mM. In 2020, Zheng et al [ 156 ] described a highly-sensitive glucose sensor, based on back-reflection configuration, using plastic cladding fiber of 600 μm. The fiber tip was coated with gold by sputtering and was then biofunctionalized with GOx enzyme.…”

Section: Biosensing Applicationsmentioning

confidence: 99%

Cost-Effective Fiber Optic Solutions for Biosensing

et al. 2022

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In the last years, optical fiber sensors have proven to be a reliable and versatile biosensing tool. Optical fiber biosensors (OFBs) are analytical devices that use optical fibers as transducers, with the advantages of being easily coated and biofunctionalized, allowing the monitorization of all functionalization and detection in real-time, as well as being small in size and geometrically flexible, thus allowing device miniaturization and portability for point-of-care (POC) testing. Knowing the potential of such biosensing tools, this paper reviews the reported OFBs which are, at the moment, the most cost-effective. Different fiber configurations are highlighted, namely, end-face reflected, unclad, D- and U-shaped, tips, ball resonators, tapered, light-diffusing, and specialty fibers. Packaging techniques to enhance OFBs’ application in the medical field, namely for implementing in subcutaneous, percutaneous, and endoscopic operations as well as in wearable structures, are presented and discussed. Interrogation approaches of OFBs using smartphones’ hardware are a great way to obtain cost-effective sensing approaches. In this review paper, different architectures of such interrogation methods and their respective applications are presented. Finally, the application of OFBs in monitoring three crucial fields of human life and wellbeing are reported: detection of cancer biomarkers, detection of cardiovascular biomarkers, and environmental monitoring.

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“…The excellent photoelectric properties were attributed to a liquid phase transfer-induced composite nanostructure, resulting in a high selectivity for glucose detection. Zheng et al improved the performance of optical-based glucose sensors by combining the SPR phenomenon with a glucose oxidase (GOD) sensitive film [ 42 ]. To generate the SPR phenomenon, a gold thin film was coated onto the surface of an optical fiber, and then a glucose oxidase (GOD) sensitive film was covalently bonded to the gold thin film.…”

Section: Surface Plasmon Resonance (Spr): Theory and Working Principlementioning

confidence: 99%

“…In general, SPR has been used to detect a variety of targets, including glucose [ 40 – 42 ], uric acid [ 43 , 44 ], dopamine [ 27 , 45 , 46 ], antibody [ 47 – 50 ], antigen [ 47 , 51 , 52 ], salmonella [ 53 ], urea [ 43 , 54 – 56 ], and creatinine [ 28 , 57 , 58 ], in a variety of applications, including material characterization, medical diagnostics, food quality sensors, and drug development. Yu et al described the development of a D-shaped fiber SPR glucose biosensor with a modified MoS2-graphene composite nanostructure that exhibits approximately fourfold increased sensitivity [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems

Mulyanti

Nugroho

Wulandari

et al. 2022

International Journal of Biomaterials

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SPR-based technology has emerged as one of the most versatile optical tools for analyzing the binding mechanism of molecular interaction due to its inherent advantages in sensing applications, such as real-time, label-free, and high sensitivity characteristics. SPR is widely used in various fields, including healthcare, environmental management, and food-borne illness analysis. Meanwhile, kidney disease has grown to be one of the world’s most serious public health problems in recent decades, resulting in physical degeneration and even death. As a result, several studies have published their findings regarding developing of reliable sensor technology based on the SPR phenomenon. However, an integrated and comprehensive discussion regarding the application of SPR-based sensors for detecting of kidney disease has not yet been found. Therefore, this review will discuss the recent advancements in the development of SPR-based sensors for monitoring kidney-related diseases. Numerous SPR configurations will be discussed, including Kretschmann, Otto, optical fiber-based SPR, and LSPR, which are all used to detect analytes associated with kidney disease, including urea, creatinine, glucose, uric acid, and dopamine. This review aims to show the broad application of SPR sensors which encouraged the development of SPR sensors for kidney problems monitoring.

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Highly-sensitive and reflective glucose sensor based on optical fiber surface plasmon resonance

Cited by 71 publications

References 30 publications

In Situ Temperature-Compensated DNA Hybridization Detection Using a Dual-Channel Optical Fiber Sensor

In Situ Temperature-Compensated DNA Hybridization Detection Using a Dual-Channel Optical Fiber Sensor

Cost-Effective Fiber Optic Solutions for Biosensing

SPR-Based Sensor for the Early Detection or Monitoring of Kidney Problems

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