Highly sensitive and selective mercury sensor based on mismatched base pairing with dioxT

Abstract

A highly selective and sensitive sensor for mercury was designed based on a new fluorescent nucleobase, dioxT.

A Disposable Electrochemical Biosensor Based on Screen-Printed Carbon Electrodes Modified with Silver Nanowires/HPMC/Chitosan/Urease for the Detection of Mercury (II) in Water

“…Heavy metal ions cause well-known and extremely severe problems in the environment and in animal and human health [1,2]. Mercury(II) ions are one of the most toxic pollutants and can spread widely in the environment from industrial wastes and natural sources [3][4][5]. Moreover, Hg(II) ions can damage human organs, resulting in serious diseases such as kidney failure and brain and heart damage [6].…”

Fundamental photophysics of isomorphic and expanded fluorescent nucleoside analogues

“…To further extend its applications, diox T was recently used as a metal sensor in a study where Sugiyama et al demonstrated that diox T•T and diox T•C mismatched base pairs in duplexes can serve as a nucleicacid-based mercury sensor. 338 The group of Sugiyama also investigated the possibility of using diox T as a FRET donor in combination with tC acting as an acceptor. Both were incorporated in doublestrand DNA in which the distance between the two dyes was systematically increased 339 .…”

Synthesis and application of a 19F-labeled fluorescent nucleoside as a dual-mode probe for i-motif DNAs

“…14 The highly selective and sensitive binding between diox T and metal ions allowed us to demonstrate its utility as a heavy metal sensor. 15 In parallel, 19 F-labeled nucleosides have been developed as versatile probes due to the practicality of 19 F NMR spectroscopy in investigating the structures and interactions of biomolecules. 16 Unique features, such as the intrinsic sensitivity of the 19 F nucleus and its absence from general biomolecules, make 19 F NMR probes highly attractive.…”

“… 14 The highly selective and sensitive binding between dioxT and metal ions allowed us to demonstrate its utility as a heavy metal sensor. 15 …”