Highly sensitive and selective method for the rapid determination and preconcentration of haloperidol by using a magnetite‐molecularly imprinted polymer

Abstract

A sensitive and selective method based on the determination of haloperidol with the usage of magnetite‐molecularly imprinted polymer and high‐resolution liquid chromatography has been developed. This novel method is rapid as the detection procedure for haloperidol can be completed within a total time of 1 h. The same imprinted polymer can be used for the determination of haloperidol at least 20 times. The proposed method has been succesfully applied to synthetic urine and serum samples and the recoveries of the spiked samples were in the range of 94.7–100.7%. The limit of detection and limit of quantification of the method were 2.25 and 7.50 μg/L, respectively. Linearity of the calibration graph was observed within the range of 10–250 μg/L. By combining the high capacity, high selectivity, and reusability of the magnetic adsorbent with the dynamic calibration range, high sensitivity and high resolution of liquid chromatography with quadrupole time‐of‐flight mass spectrometry, the proposed method is an ideal method for the determination and preconcentration of trace levels of haloperidol. A magnetite‐molecularly imprinted polymer has been used for the first time as a selective adsorbent for the determination of haloperidol.

Molecularly Imprinted Polymers for Dispersive (Micro)Solid Phase Extraction: A Review

“…[53][54][55][56][57] interact with the nanoparticle surface through one of the hydroxyl groups, allowing the remaining hydroxyl groups to be available to react with the components of the pre-polymerization mixture (Figure 2). A similar mechanism is obtained for oleic acid [91][92][93][94][95][96][97][98][99][100][101][102], which interacts with the nanoparticle's surface through the hydroxyl groups but promotes the presence of vinyl groups in the modification layer. Similarly, poly (vinyl alcohol) [59] is also a source of hydroxyl and vinyl groups for reacting with the pre-polymerization components.…”

Design and Fabrication of a Biomimetic Smart Material for Electrochemical Detection of Carbendazim Pesticides in Real Samples with Enhanced Selectivity

“…MIPs are ideal for use as sorbents in the detection of trace levels of pesticides because of their many intrinsic benefits, including their high selectivity, sensitivity [24], reusability, physicochemical stability [25], and cost-effectiveness [26]. In recent years, there has been a dramatic increase in the fascination of utilizing molecularly imprinted polymers The detection of CBZ has been investigated using a wide range of analytical methods including high-performance liquid chromatography (HPLC) [12,13], gas chromatography (GC) [5,9], liquid chromatography (LC) coupled with mass spectrometry (LC/MS-MS) [14,15], electrochemical techniques [16][17][18], and fluorescent sensors [19].…”

“…MIPs are ideal for use as sorbents in the detection of trace levels of pesticides because of their many intrinsic benefits, including their high selectivity, sensitivity [ 24 ], reusability, physicochemical stability [ 25 ], and cost-effectiveness [ 26 ]. In recent years, there has been a dramatic increase in the fascination of utilizing molecularly imprinted polymers (mag-MIP) in environmental analysis.…”

An Electrochemical Sensor Fabricated by Sonochemical Approach for Determination of the Antipsychotic Drug Haloperidol

“…It is very important to determine high-precision methods in terms of the safety and ethics of drugs during the treatment phase of the side effects caused by Hlp, the production phases of this and similar antipsychotic drugs, and clinical laboratory studies [8,9]. In recent years, various analytical procedures have been developed for much worldwide research on the determination of antipsychotic drugs, quantifying the amount of commercial formulation products in biological samples such as human blood and urine, detecting degradation products, and determining the amount of residues [10][11][12]. The haloperidol drug is metabolized to several metabolites, and enzymes involved in the biotransformation of haloperidol include cytochrome P450, carbonyl reductase, and uridine diphosphoglucose glucuronosyltransferase [13,14].…”