During the last decade, progress has been made in the on‐site detection of abused drug use. Herein, we present an electrochemical biosensor for the detection of one of the synthetic cannabinoids (SCs), JWH‐073, using poly (methyl methacrylate) (PMMA) hyperbranched copolymer (HBC) as a base coating and antibody molecules to bind the JWH‐073 to the surface. Modification of the surface is proved with various techniques such as differential pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectrometry. The limit of detection and linearity (in logarithmic scale) for JWH‐073 were found to be 31.87 ng/mL and 25–500 ng/mL, respectively. The selectivity of the proposed biosensor was also tested in the presence of interfering molecules and the response was much higher for JWH‐073 in all measurements. In the final part of the study, synthetic urine was tested with the device and the relative standard deviation value was calculated to be less than 5.0 %. The confirmation of data from the resulting bio‐platform was performed via LC‐QTOF/MS. This work is the first of its kind, a novel, rapid, cost‐effective sensing platform for the detection of the SC.

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A sensitive and selective method based on the determination of haloperidol with the usage of magnetite‐molecularly imprinted polymer and high‐resolution liquid chromatography has been developed. This novel method is rapid as the detection procedure for haloperidol can be completed within a total time of 1 h. The same imprinted polymer can be used for the determination of haloperidol at least 20 times. The proposed method has been succesfully applied to synthetic urine and serum samples and the recoveries of the spiked samples were in the range of 94.7–100.7%. The limit of detection and limit of quantification of the method were 2.25 and 7.50 μg/L, respectively. Linearity of the calibration graph was observed within the range of 10–250 μg/L. By combining the high capacity, high selectivity, and reusability of the magnetic adsorbent with the dynamic calibration range, high sensitivity and high resolution of liquid chromatography with quadrupole time‐of‐flight mass spectrometry, the proposed method is an ideal method for the determination and preconcentration of trace levels of haloperidol. A magnetite‐molecularly imprinted polymer has been used for the first time as a selective adsorbent for the determination of haloperidol.

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