2022
DOI: 10.1039/d2tb01024k
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Highly sensitive and simultaneous detection of ctDNAs related to non-small cell lung cancer in serum using a catalytic hairpin assembly strategy in a SERS microfluidic chip

Abstract: Circulating tumor DNA (ctDNA) is an ideal biomarker for cancer diagnosis based on liquid biopsy, so there is an urgent need to develop an efficient, rapid, and ultrasensitive detection method...

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Cited by 14 publications
(8 citation statements)
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“…The results were also validated and comparable to conventional qRT-PCR assays. 285 These results demonstrate the promise of SERS-based microfluidic chips for rapid, cost-effective, and highly sensitive ctDNA detection, as well as the possibility for deployment toward dynamic cancer staging monitoring and a viable clinical tool for early cancer screening (Figure 5).…”
Section: Circulating Tumor Dnamentioning
confidence: 67%
“…The results were also validated and comparable to conventional qRT-PCR assays. 285 These results demonstrate the promise of SERS-based microfluidic chips for rapid, cost-effective, and highly sensitive ctDNA detection, as well as the possibility for deployment toward dynamic cancer staging monitoring and a viable clinical tool for early cancer screening (Figure 5).…”
Section: Circulating Tumor Dnamentioning
confidence: 67%
“…Two types of biomarkers, miR-21 and miR-196a-5p, were detected simultaneously and with comparable accuracy with the existing qRT-PCR techniques. Similar studies were carried out with a flexible filter paper substrate [ 112 ] and with different biomarkers [ 113 , 114 ]. They extended their studies with ctDNA as the biomarker, thus implying the versatility of SERS [ 115 ].…”
Section: Sers For Disease Diagnosismentioning
confidence: 94%
“…Further, the authors confirm that attomolar level sensitivity and accurate quantification are present in mouse serum. Later, the authors proposed another micro fluid-based platform for evaluating expression levels of TP53 or PIK3CA -Q546K in ctDNAs [ 170 ]. TP53 is usually considered to be related to a worse prognosis and resistance to chemotherapy, and PIK3CA -Q546K plays an important role in the pathogenesis of NSCLC.…”
Section: Optical Nanomaterial-based Detection Of Lb Biomarkersmentioning
confidence: 99%