Wearable sensors afford convenience in daily health monitoring, though many challenges in the development of such systems need to be overcome. Here, we present a low power, multimodal analog front-end (AFE) for wearable health monitoring sensors based on novel system architecture and VLSI circuit design methods. The AFE integrated circuit was designed with standard 65 nm CMOS technology. Three sensor AFEs, bio-potential, photoplethysmography (PPG) and bioelectrical impedance analyzer (BIA), were integrated on the same die with an area of 2.5 × 2.5 mm 2 . The power consumption for each AFE mode was less than 0.4 mW and did not exceed 2 mW for all three modes with a 1.2V power supply. Results from each individual AFE showed high-quality, motion-robust signals (Electrocardiogram, PPG and BIA) that correlated with those obtained from clinical grade gold-standard devices for similar applications. Such multi-functional, non-intrusive systems permit users to effortlessly self-monitor multiple clinically-relevant physiological parameters.