Highly sensitive determination of perphenazine on a carbon nanocomposite ionic liquid electrode

Fasihi, Farshid; Farjami, Fatemeh; Shafiee, Gholam Hossein

doi:10.1039/c5ra14639a

Cited by 15 publications

(4 citation statements)

References 46 publications

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“…Briefly, for this group of drugs, eight different compounds were analyzed by sensors that comprised three different ILs in their composition. Various paste-based sensors employed the IL n-octylpyridinum hexafluorophosphate (OPy.PF 6 ) in the mixture apart from MWCNT and graphite, obtaining a more or less concordant analytical performance in terms of LOD, varying from 0.0065 μmol L −1 for risperidone [ 57 ] drug to 0.023 μmol L −1 for perphenazine ( Figure 4 a) [ 59 ]. The cation-π interaction of carbon nanotubes with the IL, OPy.PF 6 and their application for oxidation of perphenazine is well demonstrated in Figure 4 a.…”

Section: (Bio)sensing Strategies For Pharmaceuticals Using Electroche...mentioning

confidence: 99%

“… ( a ) Scheme representing dispersion of MWCNT in OPy.PF 6 ( A ), the cation-π interaction ( B ), and oxidation of perphenazine drug ( C ) (reproduced from Fasihi et al [ 59 ], with permission from the Royal Society of Chemistry, 2015). ( b ) Scheme of a MIP-based chlortetracycline sensor representing MWCNT modification by IL, HEMIM.BF 4 (1), synthesis of 1-carboxymethyl-3-vinylimidazolium bromide (2), preparation of MIP at the MWCNT-IL surface (3), and further modification of a GCE (4) (reproduced from Chen et al [ 66 ], with permission from Elsevier, 2021).…”

Section: Figurementioning

confidence: 99%

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(Bio)Sensing Strategies Based on Ionic Liquid-Functionalized Carbon Nanocomposites for Pharmaceuticals: Towards Greener Electrochemical Tools

et al. 2022

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The interaction of carbon-based nanomaterials and ionic liquids (ILs) has been thoroughly exploited for diverse electroanalytical solutions since the first report in 2003. This combination, either through covalent or non-covalent functionalization, takes advantage of the unique characteristics inherent to each material, resulting in synergistic effects that are conferred to the electrochemical (bio)sensing system. From one side, carbon nanomaterials offer miniaturization capacity with enhanced electron transfer rates at a reduced cost, whereas from the other side, ILs contribute as ecological dispersing media for the nanostructures, improving conductivity and biocompatibility. The present review focuses on the use of this interesting type of nanocomposites for the development of (bio)sensors specifically for pharmaceutical detection, with emphasis on the analytical (bio)sensing features. The literature search displayed the conjugation of more than 20 different ILs and several carbon nanomaterials (MWCNT, SWCNT, graphene, carbon nanofibers, fullerene, and carbon quantum dots, among others) that were applied for a large set (about 60) of pharmaceutical compounds. This great variability causes a straightforward comparison between sensors to be a challenging task. Undoubtedly, electrochemical sensors based on the conjugation of carbon nanomaterials with ILs can potentially be established as sustainable analytical tools and viable alternatives to more traditional methods, especially concerning in situ environmental analysis.

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Section: (Bio)sensing Strategies For Pharmaceuticals Using Electroche...mentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

(Bio)Sensing Strategies Based on Ionic Liquid-Functionalized Carbon Nanocomposites for Pharmaceuticals: Towards Greener Electrochemical Tools

et al. 2022

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“…[3]. and biological samples, such as HPLC [4,5], mass spectrometry [6], spectrophotometry [7,8], electrochemistry [9][10][11], electrophoresis [12] fluorescence [13] and chemiluminescence [14].…”

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confidence: 99%

The quantitative determination of Perphenazine in tablets by the spectrophotometric method as its sulfoxide obtained with diperoxyazelaic acid

Blazheyevskіy

Kucher

Shpychak³

2019

Fr. Ukr. J. Chem.

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The oxidative derivatization method using diperoxyazelaic acid for the indirect spectrophotometric determination of Perphenazine dihydrochloride is presented. Diperoxyazelaic acid is introduced as a derivatizing agent for Perphenazine, yielding sulfoxides. This reaction product was successfully employed for the spectrophotometric determination of Perphenazine dihydrochloride. The UV spectroscopic detection of sulfoxide has been proven to be the more robust and selective. The method developed allowed determination of Perphenazine dihydrochloride in the concentration range of 1–40 µg/mL. The limits of quantification (LOQ=10S) is 3.3 µg·ml-1. A new spectrophotometric method has been developed, and the possibility of the quantitative determination of Perphenazine dihydrochloride in Perphenazine Tablets has been demonstrated. The present method is precise, accurate and other inactive excipients of the drug do not interfere. RSD = 2.00%; δ=( -µ) 100%/µ = – 0.85 %).

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“…MWNTs are characterized by distinct optical, electrical, thermal, mechanical, and structural features and have the potential to be used for many different purposes [25][26][27][28]. In addition, MWNTs promote the study of their uses as new electrode materials in the field of electrochemistry due to their remarkable catalytic activity and subtle electronic properties [29][30][31][32][33][34][35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical determination of lead(II) ions in hot spring water based on a multi-walled carbon nanotube-modified glassy carbon electrode

Li¹,

Economics²

2018

International Journal of Electrochemical Science

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The present study reports the fabrication of a carbon nanotube/Nafion composite film (MWNT/Nafion)-modified glassy carbon electrode (GCE) along with its excellent performance in the analysis of Pb 2+ (favorable catalytic activity, large surface area, high cation exchange capacity, and strong adsorption ability). The stripping peak current of Pb 2+ was greatly increased at the MWNT/Nafion-coated GCE compared with the bare and Nafion-coated GCEs. The optimization of different parameters was also carried out, including optimization of the accumulation time, accumulation potential, supporting electrolyte, and MWNT/Nafion suspension volume. Therefore, our developed electrode can be used in the analysis of Pb 2+ in real hot spring water samples.

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Highly sensitive determination of perphenazine on a carbon nanocomposite ionic liquid electrode

Abstract: A multi-walled carbon nanotube–ionic liquid nanocomposite was fabricated for the electrochemical detection of perphenazine, suitable for the analysis of pharmaceuticals and blood serum samples.

Cited by 15 publications

References 46 publications

(Bio)Sensing Strategies Based on Ionic Liquid-Functionalized Carbon Nanocomposites for Pharmaceuticals: Towards Greener Electrochemical Tools

(Bio)Sensing Strategies Based on Ionic Liquid-Functionalized Carbon Nanocomposites for Pharmaceuticals: Towards Greener Electrochemical Tools

The quantitative determination of Perphenazine in tablets by the spectrophotometric method as its sulfoxide obtained with diperoxyazelaic acid

Electrochemical determination of lead(II) ions in hot spring water based on a multi-walled carbon nanotube-modified glassy carbon electrode

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