Highly-sensitive epinephrine sensors based on organic electrochemical transistors with carbon nanomaterial modified gate electrodes

Mak, Chee Leung; Liao, Caizhi; Fu, Ying; Zhang, Meng; Tang, Chun; Tsang, Yuen Hong; Chan, Helen Lai Wah; Yan, Feng

doi:10.1039/c5tc01100k

Cited by 65 publications

(40 citation statements)

References 43 publications

(59 reference statements)

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“…OECT-based sensors have also been screen-printed and functionalised using a chitosan hydrogel matrix, incorporating a ferrocene electron transfer mediator along with the corresponding oxidase enzyme for the detection of glucose and lactate on artificial sweat samples (Figure 2c). [58] Epinephrine, a key neurotransmitter, has been also detected using solution-processed OECTs with remarkable sensitivities (sub-nM) owing to a Nafion anti-interference layer and carbonbased nanomaterials co-immobilized on the gate electrodes (Figure 2d) [59]. (Figure 3a).…”

Section: Conducting Polymer-based Devicesmentioning

confidence: 99%

“…Reproduced with permission from [57] (c) Schematic diagram of the screen printed OECT and illustration showing the gate electrode functionalization, comprised of a mediator as well as current response for the enzymatic determination of lactate. Reproduced with permission from [58] (d) Schematic representation of the epinephrine OECT based sensor bearing functionalized gate electrodes and potential drop at the gate electrode upon different concentrations of epinephrine dependent on the different functionalization schemes.Reproduced with permission from[59]…”

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confidence: 99%

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Organic Electronics for Point-of-Care Metabolite Monitoring

Pappa

Parlak

Scheiblin

et al. 2018

Trends in Biotechnology

113

111

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In this review we focus on demonstrating how organic electronic materials can solve key problems in biosensing thanks to their unique material properties and implementation in innovative device configurations. We highlight specific examples where these materials solve multiple issues related to complex sensing environments, and we benchmark these examples by comparing them to state-of-the-art commercially available sensing using alternative technologies. We have categorized our examples by sample type, focusing on sensing from body fluids in vitro and on wearable sensors, which have attracted significant interest owing to their integration with everyday life activities. We finish by describing a future trend for in vivo, implantable sensors, which aims to build on current progress from sensing in biological fluids ex vivo.

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Section: Conducting Polymer-based Devicesmentioning

confidence: 99%

mentioning

confidence: 99%

Organic Electronics for Point-of-Care Metabolite Monitoring

Pappa

Parlak

Scheiblin

et al. 2018

Trends in Biotechnology

113

111

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“…[1-(3,4-dihydroxyphenyl)-2methyloaminoethanol], often called adrenaline, is one of the most important and well-known catecholamine neurotransmitters in mammalian central nervous systems, which plays an important role in the function of the central nervous, hormonal and cardiovascular systems [1,2]. Many life phenomena are connected to the concentration of epinephrine in blood.…”

Section: Epinephrinementioning

confidence: 99%

Simultaneous electrochemical determination of epinephrine and acetylcholine using modified screen printed electrode

Aflatoonian

Tajik

Ekrami‐Kakhki

et al. 2020

Eurasian Chem. Commun.

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Electrochemical behaviors of epinephrine and acetylcholine were investigated, using cyclic voltammetry, on the Ag-ZnO modified screen-printed electrode (Ag-ZnO/SPE). Ag-ZnO nanoplates showed excellent electrocatalytic activity toward the oxidation of epinephrine and acetylcholine compared with bare SPE in 0.1 M PBS. Under the optimized experimental conditions, a linear response obtained in the range of 0.13 to 450.00 μM with detection limit of 0.04 μM for epinephrine. Ag-ZnO/SPE exhibits good stability, reproducibility and repeatability, and the method has been successfully applied for detection of epinephrine and acetylcholine in their pharmaceutical and biological samples with satisfactory recovery.

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“…The sensing of a solution containing both CTAB and adrenaline has been demonstrated. Finally, Mak et al [102] fabricated epinephrine sensors where the gate electrode was modified with carbon nanomaterials, including single-walled carbon nanotubes (SWCNTs), graphene and graphene oxide, which can promote electron transfer reactions and enhance the electrocatalytic activity of the gate electrodes. A detection limit down to 0.1 nM was measured with a gate modified with Nafion and SWCNTs.…”

Section: Adrenalinementioning

confidence: 99%

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

et al. 2018

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Featured Application: Sensing organic molecules in water.Abstract: This review first recalls the basic functioning principles of organic electrochemical transistors (OECTs) then focuses on the transduction mechanisms applicable to OECTs. Materials constituting the active semiconducting part are reviewed, from the historical conducting polymers (polyaniline, polypyrrole) to the actual gold standard, poly-3,4-ethylenedioxythiophene: polystyrene sulfonic acid (PEDOT:PSS), as well as the methods used to fabricate these transistors. The review then focuses on applications of OECTs for the detection of small molecules and more particularly of metabolites, with a distinction between enzymatic and non-enzymatic transduction pathways. Finally, the few patents registered on the topic of OECT-based biosensors are reviewed, and new tracks of improvement are proposed. applied to biosensing quite early, associated with enzymes [4][5][6]. This is because, due to their functioning mechanism (already identified at the time), they brought into play the same charge carriers as most biological functions, i.e., electrons but also ions, and were therefore sensitive both to electron transfer to/from redox enzymes or ions (e.g., protons) produced from other types of enzymes. This is a characteristic which distinguished them from organic field-effect transistors (OFETs), which started to raise the attention of researchers exactly at the same period (precisely, 1983 for the first polyacetylene-based OFET [7]), and a few years later for applications to gas sensing (halogens, ammonia, oxygen [8-10] or even vapors of H 2 O, NO or H 2 O 2 [11][12][13][14]). However, OFETs never really produced any applicable results in the framework of biosensors in aqueous environment because of high operating voltages, of several tens of volts, which impede any measurements because of water electrolysis. Ion-sensitive organic field-effect transistors (ISOFETs), based on the same working principles of their inorganic counterparts (ISFETs) developed earlier [15,16], solved this problem of high operating potential, the electrolyte being not in direct contact with the semiconductor. However, these devices were confined mostly to protons detection [17][18][19] or, in any case, to charged species.As we show in this review, OECTs use both potentiometry and amperometry in their working principles. In that sense, OECTs are devices that represent a bridge between ISOFETs and classical amperometry, which certainly explains their success. This area of research is very active and several reviews have already been published on OECTs in general, for example by Kergoat et al. [1] or Rivnay et al. [3], or on OECTs applied to biology, for example by Liao and Yan [20], Liao et al. [21], Strakosas et al. [22] or . This present review, after going back to the basic functioning principles, along with details on transductions applicable to OECTs, reviews materials, fabrication techniques and then sensing applications. We focus on the detection of small molecules and more part...

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Highly-sensitive epinephrine sensors based on organic electrochemical transistors with carbon nanomaterial modified gate electrodes

Abstract: The sensitivity of OECT-based epinephrine sensors has been dramatically improved by modifying carbon nanomaterials on the Pt gate electrodes.

Cited by 65 publications

References 43 publications

Organic Electronics for Point-of-Care Metabolite Monitoring

Organic Electronics for Point-of-Care Metabolite Monitoring

Simultaneous electrochemical determination of epinephrine and acetylcholine using modified screen printed electrode

Fabrication and Use of Organic Electrochemical Transistors for Sensing of Metabolites in Aqueous Media

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